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The map label for this gene is tsr [H]

Identifier: 222110945

GI number: 222110945

Start: 1862321

End: 1863892

Strand: Direct

Name: tsr [H]

Synonym: Dtpsy_1752

Alternate gene names: 222110945

Gene position: 1862321-1863892 (Clockwise)

Preceding gene: 222110940

Following gene: 222110948

Centisome position: 49.05

GC content: 64.69

Gene sequence:

>1572_bases
ATGGAAAACTTTCGTATCGGCACCCGCCTGACGGCTGGGTTTGGCCTGCTCATCCTGTTTGCGATGCTCATGCTCACAGT
GGGGGTGTGGCAGTTGCAGGGGGTGGCCGGGAGCACGCGGCAAATCCTTTCTGTGCCGCTCCAGAAGGAACGGCTGGTGA
CCGACTGGTACGGAGTGATTCGCGCCAGCATCCAACGTGCCACTGCTGTCGCGCGCAGCAGCGACGACTCGCTGACGGAG
TTGTTCGCCGCAGAGAACGCCGCGTCGAGCAAGGAAACCAACGAACGGCAGGCCCAGTTCGTCAAGCTCATTTCCGGCAG
CGAAGAGCAAGCCCTCTTTGACACTCTCAGCGGACACCGTCAGGCATACATCCAGGCCCGTGACTCCATCATCGCCGCCA
AGAAGGGCGGGCAGGCAGAGCAGGTGACCACCCTGTTCGAGCGCCAGTTCGTTCCTGCCTCCCGTGGCTATCTGGAAAGC
CTGGCGGCGCTGCGCGACTTCCAGCGGGCCAGTATCGATCGCACCGGGCAAGACATCGACAGCAGCGCTACCGCAAGCTC
CTGGCTGATGGGCGGCATCGGGCTGGTGGTCCTGGTGGCGGGCATCGGCGTGGCCTGGATTCTTACCCACAGCATCACTG
CGCCGTTGGCCCGCGCTGTCCAAGCAACGCAGGTGGTCGCCGCAGGAGACCTCACGCATGCCGTGCACTCCAGCGGCCGG
GACGAAGGTGCCCAGCTGTTGCAAGCGCTGCAAGCCATGACCGACCGTTTGCGTACCATCGTGGGCGAAGTGCGCCAGGG
CGCCGACAGCATCGCGGGCGCGTCGGCAGAGATTGCCGCAGGCAACATGGACCTGTCCCGGCGCACGGAACAGCAGGCCA
GTTCATTGGAGGAAACGGCTGCTTCCCTGGAAGAGCTGACGTCGACGGTGCGTCAGAACGCCGACAACGCCCATCAAGCC
AACCAGCTGGCGCGCACGGCGGCAGACCAGGCACAGCAGGGCGGCCAGGTGATGGACGATGTGATGCAGACCATGCGCGC
TATCGACGCGTCGTCGCGCAAGATCGTGGACATCATTGGCGTGATCGACTCCATTGCCTTCCAGACCAACATCCTTGCGC
TCAACGCGGCGGTCGAAGCGGCACGGGCCGGCGAGCAGGGGCGGGGGTTTGCCGTGGTGGCCTCCGAAGTGCGCTCATTG
GCCGGCCGCTCGTCCGAAGCGGCGAAGGAAATCAAGGACTTGATCGGACGTTCGGTCGATACCGTCGAGGCGGGTAACCA
ACTCGTGGCGAAGGCCGGCACATCCATCCAGGACATCATTCGCAGCGTTGACCAGGTGAGCGCGCTGGTGGGCGAAATCA
GTGCGGCAAGCCGTGAACAGAGCTCGGGCATCGAGCAGGTGAATATCGCGGTGGCGCACATGGACCAGGCGACGCAGCAG
AATGCCGCGCTCGTCGAAGAGGCCACCGCTGCGACGCAATCGCTGCAGGGCCAGGCGGCGCAAGTGGCCCAGGCCGTAGG
GGTCTTTCGCGTTGATTCCTCGGCAGTCGCGTTGCCGGCACCGCAGGCCTGA

Upstream 100 bases:

>100_bases
CCACTTCCGAATAAAGTCACACTTATTTACATTTGGCGGTTTTTCCTTCTCGTGCTTGCTTCACAGACGGTAAGTCAGCC
GTTCACGTTCCGAGGGACAT

Downstream 100 bases:

>100_bases
TCCTGGATACCACCGCACACCCCGGCGGGCCCCCGGGGCCTGGCGCTGGCGTAAGGGCAACGGCTGGCTTACCTGGGCGT
CAGCAACAGCCGCGCCTCGA

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: MCP-I; Serine chemoreceptor protein [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MENFRIGTRLTAGFGLLILFAMLMLTVGVWQLQGVAGSTRQILSVPLQKERLVTDWYGVIRASIQRATAVARSSDDSLTE
LFAAENAASSKETNERQAQFVKLISGSEEQALFDTLSGHRQAYIQARDSIIAAKKGGQAEQVTTLFERQFVPASRGYLES
LAALRDFQRASIDRTGQDIDSSATASSWLMGGIGLVVLVAGIGVAWILTHSITAPLARAVQATQVVAAGDLTHAVHSSGR
DEGAQLLQALQAMTDRLRTIVGEVRQGADSIAGASAEIAAGNMDLSRRTEQQASSLEETAASLEELTSTVRQNADNAHQA
NQLARTAADQAQQGGQVMDDVMQTMRAIDASSRKIVDIIGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSL
AGRSSEAAKEIKDLIGRSVDTVEAGNQLVAKAGTSIQDIIRSVDQVSALVGEISAASREQSSGIEQVNIAVAHMDQATQQ
NAALVEEATAATQSLQGQAAQVAQAVGVFRVDSSAVALPAPQA

Sequences:

>Translated_523_residues
MENFRIGTRLTAGFGLLILFAMLMLTVGVWQLQGVAGSTRQILSVPLQKERLVTDWYGVIRASIQRATAVARSSDDSLTE
LFAAENAASSKETNERQAQFVKLISGSEEQALFDTLSGHRQAYIQARDSIIAAKKGGQAEQVTTLFERQFVPASRGYLES
LAALRDFQRASIDRTGQDIDSSATASSWLMGGIGLVVLVAGIGVAWILTHSITAPLARAVQATQVVAAGDLTHAVHSSGR
DEGAQLLQALQAMTDRLRTIVGEVRQGADSIAGASAEIAAGNMDLSRRTEQQASSLEETAASLEELTSTVRQNADNAHQA
NQLARTAADQAQQGGQVMDDVMQTMRAIDASSRKIVDIIGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSL
AGRSSEAAKEIKDLIGRSVDTVEAGNQLVAKAGTSIQDIIRSVDQVSALVGEISAASREQSSGIEQVNIAVAHMDQATQQ
NAALVEEATAATQSLQGQAAQVAQAVGVFRVDSSAVALPAPQA
>Mature_523_residues
MENFRIGTRLTAGFGLLILFAMLMLTVGVWQLQGVAGSTRQILSVPLQKERLVTDWYGVIRASIQRATAVARSSDDSLTE
LFAAENAASSKETNERQAQFVKLISGSEEQALFDTLSGHRQAYIQARDSIIAAKKGGQAEQVTTLFERQFVPASRGYLES
LAALRDFQRASIDRTGQDIDSSATASSWLMGGIGLVVLVAGIGVAWILTHSITAPLARAVQATQVVAAGDLTHAVHSSGR
DEGAQLLQALQAMTDRLRTIVGEVRQGADSIAGASAEIAAGNMDLSRRTEQQASSLEETAASLEELTSTVRQNADNAHQA
NQLARTAADQAQQGGQVMDDVMQTMRAIDASSRKIVDIIGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSL
AGRSSEAAKEIKDLIGRSVDTVEAGNQLVAKAGTSIQDIIRSVDQVSALVGEISAASREQSSGIEQVNIAVAHMDQATQQ
NAALVEEATAATQSLQGQAAQVAQAVGVFRVDSSAVALPAPQA

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=366, Percent_Identity=51.6393442622951, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1787690, Length=409, Percent_Identity=45.9657701711491, Blast_Score=314, Evalue=8e-87,
Organism=Escherichia coli, GI1788195, Length=302, Percent_Identity=56.6225165562914, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1788194, Length=325, Percent_Identity=52.9230769230769, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789453, Length=318, Percent_Identity=38.0503144654088, Blast_Score=198, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR003122
- InterPro:   IPR004091
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 55045; Mature: 55045

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFRIGTRLTAGFGLLILFAMLMLTVGVWQLQGVAGSTRQILSVPLQKERLVTDWYGVI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHH
RASIQRATAVARSSDDSLTELFAAENAASSKETNERQAQFVKLISGSEEQALFDTLSGHR
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
QAYIQARDSIIAAKKGGQAEQVTTLFERQFVPASRGYLESLAALRDFQRASIDRTGQDID
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
SSATASSWLMGGIGLVVLVAGIGVAWILTHSITAPLARAVQATQVVAAGDLTHAVHSSGR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEGAQLLQALQAMTDRLRTIVGEVRQGADSIAGASAEIAAGNMDLSRRTEQQASSLEETA
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHH
ASLEELTSTVRQNADNAHQANQLARTAADQAQQGGQVMDDVMQTMRAIDASSRKIVDIIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHH
VIDSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSLAGRSSEAAKEIKDLIGRSVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
TVEAGNQLVAKAGTSIQDIIRSVDQVSALVGEISAASREQSSGIEQVNIAVAHMDQATQQ
HHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
NAALVEEATAATQSLQGQAAQVAQAVGVFRVDSSAVALPAPQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MENFRIGTRLTAGFGLLILFAMLMLTVGVWQLQGVAGSTRQILSVPLQKERLVTDWYGVI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHH
RASIQRATAVARSSDDSLTELFAAENAASSKETNERQAQFVKLISGSEEQALFDTLSGHR
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
QAYIQARDSIIAAKKGGQAEQVTTLFERQFVPASRGYLESLAALRDFQRASIDRTGQDID
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
SSATASSWLMGGIGLVVLVAGIGVAWILTHSITAPLARAVQATQVVAAGDLTHAVHSSGR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEGAQLLQALQAMTDRLRTIVGEVRQGADSIAGASAEIAAGNMDLSRRTEQQASSLEETA
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHH
ASLEELTSTVRQNADNAHQANQLARTAADQAQQGGQVMDDVMQTMRAIDASSRKIVDIIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHH
VIDSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRSLAGRSSEAAKEIKDLIGRSVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
TVEAGNQLVAKAGTSIQDIIRSVDQVSALVGEISAASREQSSGIEQVNIAVAHMDQATQQ
HHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
NAALVEEATAATQSLQGQAAQVAQAVGVFRVDSSAVALPAPQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6402709; 7610040; 9278503; 8384293; 6213619; 2033064; 10466731 [H]