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The map label for this gene is lrp [H]

Identifier: 222110938

GI number: 222110938

Start: 1853393

End: 1853860

Strand: Direct

Name: lrp [H]

Synonym: Dtpsy_1745

Alternate gene names: 222110938

Gene position: 1853393-1853860 (Clockwise)

Preceding gene: 222110925

Following gene: 222110940

Centisome position: 48.82

GC content: 62.18

Gene sequence:

>468_bases
ATGCAGCACATGGATCGCCTAGACAGAAAAATTCTCTCCGTCCTGCAAGGCAATGCACGCGCCAGCCTGCAAGAGATTGG
CGCCGCCGTCGGCCTGAGCCCCTCGCCGTGCTGGGGCCGCATCAAGAAGATGGAGGAGGCCGGCGTGATCGAAGGCTATA
CCGTGCGCCTGAACCCGCTGGCGCTGGACCTGGGCGACACGGTGCTGGTGCAGGTGACGCTGGACAGCCATTCGGACAAC
ACGCTGGAAAAGTTCGGCGAGATGCTTGCCAGTATCCCGGAAGTGGTGGAGGCGCACCTGGTCTCTGGCGACTACGATTA
CCTGCTGCGCGTGGTGGTCAAAGACACGCGCGACTACGAGCGCCTGCTGCGCGAGAAGCTTTACAGGATCAAGGGTATAC
GCCACAGCCGCTCGAGCTTCGTGTTGCGCACGCTCAAGAAGGCGGACCTGCCCCTGTTCCCGGGTTAA

Upstream 100 bases:

>100_bases
GAAGAAGTATGCGCCGCGGGTTGTGGATGAATTTGCTGAATTTCTCTATAAAAACCTACATTGAAGAAAAATTTTCTGCA
GTATCTAGGTTTCACGAATA

Downstream 100 bases:

>100_bases
CACTTCTCGCGGCGATTGGCCGTCAGAACTTCCACGTCACGTCCAGGCGTACGTTGCGGCCCGGCTCGGCGAAGCCCCGG
CCACTGATGGCGCCAGCGGT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MQHMDRLDRKILSVLQGNARASLQEIGAAVGLSPSPCWGRIKKMEEAGVIEGYTVRLNPLALDLGDTVLVQVTLDSHSDN
TLEKFGEMLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLLREKLYRIKGIRHSRSSFVLRTLKKADLPLFPG

Sequences:

>Translated_155_residues
MQHMDRLDRKILSVLQGNARASLQEIGAAVGLSPSPCWGRIKKMEEAGVIEGYTVRLNPLALDLGDTVLVQVTLDSHSDN
TLEKFGEMLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLLREKLYRIKGIRHSRSSFVLRTLKKADLPLFPG
>Mature_155_residues
MQHMDRLDRKILSVLQGNARASLQEIGAAVGLSPSPCWGRIKKMEEAGVIEGYTVRLNPLALDLGDTVLVQVTLDSHSDN
TLEKFGEMLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLLREKLYRIKGIRHSRSSFVLRTLKKADLPLFPG

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=40.5405405405405, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1790182, Length=143, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17431; Mature: 17431

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHMDRLDRKILSVLQGNARASLQEIGAAVGLSPSPCWGRIKKMEEAGVIEGYTVRLNPL
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECEE
ALDLGDTVLVQVTLDSHSDNTLEKFGEMLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYE
EEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHH
RLLREKLYRIKGIRHSRSSFVLRTLKKADLPLFPG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQHMDRLDRKILSVLQGNARASLQEIGAAVGLSPSPCWGRIKKMEEAGVIEGYTVRLNPL
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECEE
ALDLGDTVLVQVTLDSHSDNTLEKFGEMLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYE
EEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHH
RLLREKLYRIKGIRHSRSSFVLRTLKKADLPLFPG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]