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The map label for this gene is iscS [H]

Identifier: 222110832

GI number: 222110832

Start: 1730337

End: 1731557

Strand: Direct

Name: iscS [H]

Synonym: Dtpsy_1638

Alternate gene names: 222110832

Gene position: 1730337-1731557 (Clockwise)

Preceding gene: 222110831

Following gene: 222110833

Centisome position: 45.58

GC content: 61.67

Gene sequence:

>1221_bases
ATGGACATGACTCCGCATTTCCCTATCTATCTTGACTACGGCGCCACGACCCCCGTGGACGGCCGGGTCGTCGACGCGAT
GATTCCCTGGTTGCGCGAACATTTCGGCAACCCGGCGTCGCGCAGCCACGCCTGGGGCTGGGAGGCCGAAGAGGCCGTGG
AGCAAGCCCGCGGCCATGTGGCCGATCTGATCGGCGCCGACCCGCGCGAGATCGTGTGGACCTCGGGCGCCACTGAATCC
AACAACCTCGCCATCAAGGGCGCTGCCCATTTCTACCAAGGCAAGGGCAAGCATCTCATCACCGTGAAGACGGAGCACAA
GGCCGTCCTTGACGTGATGCGTGAACTGGAGCGCCAAGGCTTCGAGGTGACCTACCTCGATGTGCAGGAGAACGGCCTGC
TCGACATCGAGAAGTTCAAGGCCGCCATCCGCCCTGACACGATCCTGGCCAGTGTCATGTTCGTGAACAACGAAATCGGC
GTGATCCAGGACATTCCCCAGCTGGGTGCGCTCTGCCGCGAGAAGGGCATCATTTTTCATGTGGATGCCGCGCAGGCCAC
CGGCAAGGTCGAAATCGACCTGAACCAATTGCCCGTGGATTTGATGAGCCTGGCTTCGCACAAGACTTACGGACCCAAGG
GCATCGGAGCCCTGTACGTGCGCCGCAAGCCGCGCGTGCGCCTGGAAGCGCAGATGCATGGTGGCGGGCACGAGCGTGGC
ATGCGTTCGGGCACGTTGCCCACCCACCAGATTGTGGGCATGGGCGAGGCTTTCCGCCTGGCCAAGCTGGAAATGGCCCA
GGATTTGGGCAAGGTCCAAGCGCTGCAAAAGCGTCTGCTGGACGGTCTGAAGGATGTGGAGCAGGTCTTTATCAACGGCG
ACCTGGAGCGGCGCGTACCCCACAACCTGAACATGAGCTTCAACTTCGTGGAAGGCGAATCCCTGATCATGGGCATCAAG
GGACTGGCAGTGTCTTCCGGGTCGGCTTGCACTTCGGCGAGCCTGGAACCCAGCTATGTGCTGCGTGCCCTGGGTCGCAG
CGATGAGCTGGCCCACAGCAGCCTGCGCATGACCATTGGCCGTTTCACGACGGAAGAGGAAATTGACTACGCGATCAGCA
CCATCCGGCACAACGTCGCCAAGTTGCGTGAGTTGAGCCCCCTCTGGGAGATGTACCAGGATGGGGTGGACCTGAGCACC
ATCCAATGGGCGGCTCACTGA

Upstream 100 bases:

>100_bases
CAGGCTGACCCGCGCCGGCCACTGGCTGCGCGCCGGGCGGGCTCGCCACGTCGACCCTATTGCTTTCTGATGCCAGCCAG
AACCTTTCACTGAGCCAGCC

Downstream 100 bases:

>100_bases
CCACACGCGGCACGACGGAATACAGGAGAAACACACCATGGCTTACTCGGACAAAGTGATTGACCATTACGAGAACCCCC
GCAATGTGGGTTCCTTCGAC

Product: cysteine desulfurase iscs

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MDMTPHFPIYLDYGATTPVDGRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEQARGHVADLIGADPREIVWTSGATES
NNLAIKGAAHFYQGKGKHLITVKTEHKAVLDVMRELERQGFEVTYLDVQENGLLDIEKFKAAIRPDTILASVMFVNNEIG
VIQDIPQLGALCREKGIIFHVDAAQATGKVEIDLNQLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRLAKLEMAQDLGKVQALQKRLLDGLKDVEQVFINGDLERRVPHNLNMSFNFVEGESLIMGIK
GLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIGRFTTEEEIDYAISTIRHNVAKLRELSPLWEMYQDGVDLST
IQWAAH

Sequences:

>Translated_406_residues
MDMTPHFPIYLDYGATTPVDGRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEQARGHVADLIGADPREIVWTSGATES
NNLAIKGAAHFYQGKGKHLITVKTEHKAVLDVMRELERQGFEVTYLDVQENGLLDIEKFKAAIRPDTILASVMFVNNEIG
VIQDIPQLGALCREKGIIFHVDAAQATGKVEIDLNQLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRLAKLEMAQDLGKVQALQKRLLDGLKDVEQVFINGDLERRVPHNLNMSFNFVEGESLIMGIK
GLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIGRFTTEEEIDYAISTIRHNVAKLRELSPLWEMYQDGVDLST
IQWAAH
>Mature_406_residues
MDMTPHFPIYLDYGATTPVDGRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEQARGHVADLIGADPREIVWTSGATES
NNLAIKGAAHFYQGKGKHLITVKTEHKAVLDVMRELERQGFEVTYLDVQENGLLDIEKFKAAIRPDTILASVMFVNNEIG
VIQDIPQLGALCREKGIIFHVDAAQATGKVEIDLNQLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
MRSGTLPTHQIVGMGEAFRLAKLEMAQDLGKVQALQKRLLDGLKDVEQVFINGDLERRVPHNLNMSFNFVEGESLIMGIK
GLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIGRFTTEEEIDYAISTIRHNVAKLRELSPLWEMYQDGVDLST
IQWAAH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=58.25, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI156713448, Length=423, Percent_Identity=32.387706855792, Blast_Score=202, Evalue=6e-52,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=69.4029850746269, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI1787970, Length=385, Percent_Identity=23.6363636363636, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789175, Length=213, Percent_Identity=30.5164319248826, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=59.1022443890274, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17533177, Length=324, Percent_Identity=30.5555555555556, Blast_Score=134, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=56.390977443609, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=58, Blast_Score=483, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44981; Mature: 44981

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMTPHFPIYLDYGATTPVDGRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEQARGHV
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHH
ADLIGADPREIVWTSGATESNNLAIKGAAHFYQGKGKHLITVKTEHKAVLDVMRELERQG
HHHHCCCCHHEEEECCCCCCCCEEEEECHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCC
FEVTYLDVQENGLLDIEKFKAAIRPDTILASVMFVNNEIGVIQDIPQLGALCREKGIIFH
CEEEEEEECCCCCEEHHHHHHHCCCHHHHEEEEEECCCCCHHHCCHHHHHHHHHCCCEEE
VDAAQATGKVEIDLNQLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
EECCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCHHCC
MRSGTLPTHQIVGMGEAFRLAKLEMAQDLGKVQALQKRLLDGLKDVEQVFINGDLERRVP
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
HNLNMSFNFVEGESLIMGIKGLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIG
CCCCCEEEEECCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RFTTEEEIDYAISTIRHNVAKLRELSPLWEMYQDGVDLSTIQWAAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MDMTPHFPIYLDYGATTPVDGRVVDAMIPWLREHFGNPASRSHAWGWEAEEAVEQARGHV
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHH
ADLIGADPREIVWTSGATESNNLAIKGAAHFYQGKGKHLITVKTEHKAVLDVMRELERQG
HHHHCCCCHHEEEECCCCCCCCEEEEECHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCC
FEVTYLDVQENGLLDIEKFKAAIRPDTILASVMFVNNEIGVIQDIPQLGALCREKGIIFH
CEEEEEEECCCCCEEHHHHHHHCCCHHHHEEEEEECCCCCHHHCCHHHHHHHHHCCCEEE
VDAAQATGKVEIDLNQLPVDLMSLASHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERG
EECCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCHHCC
MRSGTLPTHQIVGMGEAFRLAKLEMAQDLGKVQALQKRLLDGLKDVEQVFINGDLERRVP
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
HNLNMSFNFVEGESLIMGIKGLAVSSGSACTSASLEPSYVLRALGRSDELAHSSLRMTIG
CCCCCEEEEECCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RFTTEEEIDYAISTIRHNVAKLRELSPLWEMYQDGVDLSTIQWAAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA