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The map label for this gene is icd [H]

Identifier: 222110759

GI number: 222110759

Start: 1647205

End: 1648464

Strand: Direct

Name: icd [H]

Synonym: Dtpsy_1562

Alternate gene names: 222110759

Gene position: 1647205-1648464 (Clockwise)

Preceding gene: 222110756

Following gene: 222110760

Centisome position: 43.39

GC content: 62.78

Gene sequence:

>1260_bases
ATGACCAGCTACCAGCACATCCAGATTCCGCCCCAGGGCCAGAAGATCACCGTCAACGCCGACATGTCGCTGAACGTGCC
CCACCAGCCCATCATCCCGTTCATCGAGGGCGATGGCACGGGCATGGACATCACGCCCGTGATGCTCAAGGTGGTGGATG
CGGCTGTGGCAAAGTCTTATGGCGGGCAGCGCAAGATCCACTGGATGGAGGTGTATGCCGGCGAGAAGGCCACCAAGGTC
TATGGCCCCGACGTGTGGCTGCCCGAAGAGACGCTGCACGCCGTGCGCGACTACGTGGTTTCCATCAAGGGGCCGCTCAC
CACGCCCGTGGGCGGCGGCATCCGTTCGCTGAACGTGGCGCTGCGCCAGGAGCTGGACCTGTACGTCTGCCTGCGCCCGG
TGCGCTACTTCAAGGGCGTGCCTTCGCCGGTGCGTGAGCCCGAGAAGACCAACATGGTCATCTTTCGCGAGAACTCCGAG
GACATCTATGCCGGCATCGAGTTTGAGGCCGAGTCGGACAAGGCCAAGAAGCTCATCAAGTTCTTGCAGGAGGAGTTCGG
CGTCAAGAAGATCCGCTTTCCTGAAACGTCGGGCATCGGGGTCAAGCCGGTGTCGCGCGAGGGCACGCAGCGCCTGGTGC
GCAAGGCCATCCAGTACGCCATCGACAATGACCGGCCCAGCGTGACCCTGGTGCACAAGGGCAACATCATGAAGTTCACC
GAAGGGGGCTTTCGTGACTGGGGCTATGAACTGGCAGCCCAGGAATTTGGCGCGCAGCTGATCGACGGCGGCCCGTGGAT
GCGCATCAAGAATCCCCGCACCGGCAAGGACATCACCATCAAAGACAGCATCGCCGACGCCTTCCTGCAGCAGATCCTGC
TGCGCCCGGCCGAGTACAGCGTGATCGCCACGCTGAACCTGAATGGCGACTACATCTCCGACGCATTGGCGGCGCAGGTG
GGCGGCATCGGCATCGCCCCGGGTGCCAACCTGTCCGACAGCGTGGCGATGTTCGAGGCCACCCATGGCACGGCCCCCAA
GTACGCGGGAAAGGACTATGTCAACCCGGGCTCCGAGATCCTCTCGGCCGAGATGATGCTGCGCCACATGGGCTGGACCG
AGGCGGCCGACCTGATCATCAGTTCCATGGAGAAGGCCATCCAGAGCAAGAAGGTAACTTATGACTTTGCGCGCCTCATG
GACGGGGCCACGCAGGTGAGCTGCTCGGGCTTCGGGCAGGTGATGATCGACCACATGTAA

Upstream 100 bases:

>100_bases
GCAGGGCGGGCCACCCTGCAGCCTTGCCCTAGAATCTTTGGGCCCGTTCCTGCGCGAGCAGCCCGCCGCCTTGCGCACGC
ACCTACAGGAGACCCGCTTC

Downstream 100 bases:

>100_bases
GCGCCCCGCCAACCACGGGTGCGTGACTGGGCCCGCCGCTGGTCGGCGGGTTTTTTTGCCCTAGCGCAAGGTCAGCGCCC
AGCAAAAAGGCCATCCCAAC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTSYQHIQIPPQGQKITVNADMSLNVPHQPIIPFIEGDGTGMDITPVMLKVVDAAVAKSYGGQRKIHWMEVYAGEKATKV
YGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVREPEKTNMVIFRENSE
DIYAGIEFEAESDKAKKLIKFLQEEFGVKKIRFPETSGIGVKPVSREGTQRLVRKAIQYAIDNDRPSVTLVHKGNIMKFT
EGGFRDWGYELAAQEFGAQLIDGGPWMRIKNPRTGKDITIKDSIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQV
GGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSMEKAIQSKKVTYDFARLM
DGATQVSCSGFGQVMIDHM

Sequences:

>Translated_419_residues
MTSYQHIQIPPQGQKITVNADMSLNVPHQPIIPFIEGDGTGMDITPVMLKVVDAAVAKSYGGQRKIHWMEVYAGEKATKV
YGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVREPEKTNMVIFRENSE
DIYAGIEFEAESDKAKKLIKFLQEEFGVKKIRFPETSGIGVKPVSREGTQRLVRKAIQYAIDNDRPSVTLVHKGNIMKFT
EGGFRDWGYELAAQEFGAQLIDGGPWMRIKNPRTGKDITIKDSIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQV
GGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSMEKAIQSKKVTYDFARLM
DGATQVSCSGFGQVMIDHM
>Mature_418_residues
TSYQHIQIPPQGQKITVNADMSLNVPHQPIIPFIEGDGTGMDITPVMLKVVDAAVAKSYGGQRKIHWMEVYAGEKATKVY
GPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEFEAESDKAKKLIKFLQEEFGVKKIRFPETSGIGVKPVSREGTQRLVRKAIQYAIDNDRPSVTLVHKGNIMKFTE
GGFRDWGYELAAQEFGAQLIDGGPWMRIKNPRTGKDITIKDSIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSMEKAIQSKKVTYDFARLMD
GATQVSCSGFGQVMIDHM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=386, Percent_Identity=31.6062176165803, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=26.9886363636364, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=26.7045454545455, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178838, Length=304, Percent_Identity=27.3026315789474, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4758582, Length=297, Percent_Identity=28.2828282828283, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.0441988950276, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787381, Length=413, Percent_Identity=74.5762711864407, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=26.790450928382, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081683, Length=403, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71986051, Length=382, Percent_Identity=31.6753926701571, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=29.8360655737705, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=297, Percent_Identity=30.3030303030303, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=280, Percent_Identity=26.0714285714286, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324709, Length=393, Percent_Identity=29.0076335877863, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322097, Length=367, Percent_Identity=27.7929155313352, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=27.5675675675676, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319830, Length=358, Percent_Identity=25.9776536312849, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643268, Length=383, Percent_Identity=33.420365535248, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24643270, Length=383, Percent_Identity=33.420365535248, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=30.8483290488432, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI161078639, Length=281, Percent_Identity=27.7580071174377, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI161078633, Length=276, Percent_Identity=28.2608695652174, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24650122, Length=276, Percent_Identity=28.2608695652174, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI161078635, Length=276, Percent_Identity=28.2608695652174, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI161078637, Length=276, Percent_Identity=28.2608695652174, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI20130355, Length=388, Percent_Identity=23.9690721649485, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI281362242, Length=338, Percent_Identity=28.1065088757396, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648872, Length=338, Percent_Identity=28.1065088757396, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46174; Mature: 46042

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYQHIQIPPQGQKITVNADMSLNVPHQPIIPFIEGDGTGMDITPVMLKVVDAAVAKSY
CCCCCEEEECCCCCEEEEECCEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
GGQRKIHWMEVYAGEKATKVYGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVA
CCCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHH
LRQELDLYVCLRPVRYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEFEAESDKAKKLIK
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHH
FLQEEFGVKKIRFPETSGIGVKPVSREGTQRLVRKAIQYAIDNDRPSVTLVHKGNIMKFT
HHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEC
EGGFRDWGYELAAQEFGAQLIDGGPWMRIKNPRTGKDITIKDSIADAFLQQILLRPAEYS
CCCCCHHHHHHHHHHHCCEEECCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEE
VIATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEI
EEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
LSAEMMLRHMGWTEAADLIISSMEKAIQSKKVTYDFARLMDGATQVSCSGFGQVMIDHM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCCCCCEEEECC
>Mature Secondary Structure 
TSYQHIQIPPQGQKITVNADMSLNVPHQPIIPFIEGDGTGMDITPVMLKVVDAAVAKSY
CCCCEEEECCCCCEEEEECCEEECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
GGQRKIHWMEVYAGEKATKVYGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVA
CCCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHH
LRQELDLYVCLRPVRYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEFEAESDKAKKLIK
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHH
FLQEEFGVKKIRFPETSGIGVKPVSREGTQRLVRKAIQYAIDNDRPSVTLVHKGNIMKFT
HHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEC
EGGFRDWGYELAAQEFGAQLIDGGPWMRIKNPRTGKDITIKDSIADAFLQQILLRPAEYS
CCCCCHHHHHHHHHHHCCEEECCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEE
VIATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEI
EEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
LSAEMMLRHMGWTEAADLIISSMEKAIQSKKVTYDFARLMDGATQVSCSGFGQVMIDHM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]