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The map label for this gene is dnaX [H]

Identifier: 222110704

GI number: 222110704

Start: 1588968

End: 1591004

Strand: Direct

Name: dnaX [H]

Synonym: Dtpsy_1507

Alternate gene names: 222110704

Gene position: 1588968-1591004 (Clockwise)

Preceding gene: 222110702

Following gene: 222110705

Centisome position: 41.85

GC content: 70.05

Gene sequence:

>2037_bases
ATGTCCTATCTTGTGCTCGCCCGCAAATACCGTCCCAAGACCTTCTCTGAGATGGTGGGGCAGGAGCACGTGGTGCAGGC
GCTCTCCAACGCGCTCACGCAGCAGCGGCTGCACCACGCATACCTGTTCACCGGCACGCGCGGCGTGGGCAAAACCACGG
TCTCGCGCATCCTGGCCAAATCGCTCAATTGCCAGGGGCCGGACGGCCAAGGCGGCATCACTGCCACGCCCTGCGGCGTG
TGCCCGGCCTGTACCGACATCGACAGCGGCCGGTTTCCTGACTACACCGAGCTGGATGCCGCCTCCAATCGCGGCGTGGA
CGAGGTGCAGGGGCTGCTGGAGCAGGCCGTCTACAAGCCGGTGCAGGGGCGCTTCAAGGTCTTCATGATCGACGAAGTGC
ACATGCTCACGAACACGGCGTTCAACGCCATGCTCAAGACGCTGGAGGAGCCGCCGGAATACCTCAAGTTCGTGCTGGCC
ACCACCGATCCACAGAAGGTGCCAGTCACGGTGCTCTCGCGCTGCCTGCAGTTCAACCTGCGGCCCATGGCGCCCGAGAC
GGTGCTGGAGCACCTCACCCGCGTGCTCGCCGCCGAGAACGTGCCCGCCGAGCCGCAGGCCCTGCGGCTGCTGGCCCGCG
CCGCGCGCGGTTCCATGCGCGACGCGCTCAGCCTGACCGACCAGGCGATTGCCTTCGGCAGCGGCCAATTGCAGGAAGCC
GCTGTGCGCCAGATGCTGGGCAGCGTGGACCGCAGCCATGTGTTCCGTCTGATCGACGCGCTGGCGCAGGGCGATGGCCG
CACGGTGGTCGAGACGGCGGACACCCTGCGCATCAACGGCCTGTCCGCCGCCTCCACGCTGGAGGACATGAGCGCCGTGC
TGCAGCGCATGGCCGTGCTGCAGGCCGTTCCGCAGATGGCTGCGGCCGCGGACGCCAGCGACCCTGAGGCGGCAGAGGTT
GCGCGCCTGTCTGCCGCCCTGCCGGCCGACGAGACGCAGCTGCTGTACAGCATCTGTCTGCACGGCCGCGCCGATCTGGG
TCTGGCGCCCGACGAATATGCCGCGCTGACCATGGTGCTGCTGCGCCTGTTGGCGTTCAAGCCGGCGGCTTCGGAAGGCG
GCGCGGCTGCCTCGGCTGAAAAAAAAACTCTGACGCGGCCTGAAGCCGCAGCGCCGTCGGCCCATGCGCCGGCCGATACG
CCGGTAGTCCAGGCACCGCAGGCTGTGCCGGCCGCCGCGGACCGGGCTCCCGCACCGCCGGTGTCGGTGCACCCGGCTCC
GGTCGAGGCGCCCGCGATGGACTGCGCGACTGCCGCGCCCGCCCGGCCCGCCGCATCGGCAGCACCCACGCGGGCGCAAG
CCACGCCGGACGATGTGAACCAGGCCGTGCAGGAGGCGTTGGACGCGGGCGACCGCGAATCGCCCCCGTGGGAAGCCGGC
GATACGGCCCAGGCGCCCGTACGGGCCGCAGCGCCTGTGCGTCTGCCCGTACGCTCCCCTGAGGATCTAAGGCAAAAAAC
ACCTCTAGCGCCCGCCCATACAGCGCAGACAGCTCCTGAAACGGTAGCAATCCCCGTGCGTACCGCGCCGGAACCCGGGG
CGCGCCTGCAGCCCCTGCCATCGGCGGCCCCGGCACCCGCGCGGCTGGTGCGCACGGAGGAGGGCGATGTCTGGCATGCC
ACCGTGCAGCAGCTCATTGCCCAGGAGGCCATCACCGCCCTGGTGCGCGAACTGGCGCTGCAGTCGCAGCTGGTGGCGCG
TGACCCGGACCATTGGCTGCTGCGCGTGGAGCGGGAGTCGCTCAACCAGCCCACGGCGCGCGAGCGCCTGCGCGCGGCGC
TGGAGGCCGCGGGCCATGCGCGCCAGATCAGCGTGGAGGTGGGTGTGGTGATCGACAGCCCCGCGCGCCGCAACGCGCAC
GCCGCGGCCGAACGCCAGCGCGTGGCCGAGGAGATCGTCCACAACGACCCCTACGTGCAGCAACTGATGCGTGATTTCGG
GGCGAAAATCGTCCCGGGCAGCATCAAGCCTGCATAA

Upstream 100 bases:

>100_bases
AAAGCAGATCGCCCTCGGTTGGCGCGGTGGCCTGCGTAGGCACGGGCCAGCTAGAAGCCTTGGCGCGCTGGTGTCTGGCC
CGCACATAGAATCACGCCCC

Downstream 100 bases:

>100_bases
CCATTTTTGAAACGCAAAGGAAACCATCCATGTTCAACAAGGGACAGCTCGCCGGCCTCATGAAGCAGGCCCAGGCCATG
CAGGACAACCTGAAGAAGGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MSYLVLARKYRPKTFSEMVGQEHVVQALSNALTQQRLHHAYLFTGTRGVGKTTVSRILAKSLNCQGPDGQGGITATPCGV
CPACTDIDSGRFPDYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLA
TTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLAAENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLQEA
AVRQMLGSVDRSHVFRLIDALAQGDGRTVVETADTLRINGLSAASTLEDMSAVLQRMAVLQAVPQMAAAADASDPEAAEV
ARLSAALPADETQLLYSICLHGRADLGLAPDEYAALTMVLLRLLAFKPAASEGGAAASAEKKTLTRPEAAAPSAHAPADT
PVVQAPQAVPAAADRAPAPPVSVHPAPVEAPAMDCATAAPARPAASAAPTRAQATPDDVNQAVQEALDAGDRESPPWEAG
DTAQAPVRAAAPVRLPVRSPEDLRQKTPLAPAHTAQTAPETVAIPVRTAPEPGARLQPLPSAAPAPARLVRTEEGDVWHA
TVQQLIAQEAITALVRELALQSQLVARDPDHWLLRVERESLNQPTARERLRAALEAAGHARQISVEVGVVIDSPARRNAH
AAAERQRVAEEIVHNDPYVQQLMRDFGAKIVPGSIKPA

Sequences:

>Translated_678_residues
MSYLVLARKYRPKTFSEMVGQEHVVQALSNALTQQRLHHAYLFTGTRGVGKTTVSRILAKSLNCQGPDGQGGITATPCGV
CPACTDIDSGRFPDYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLA
TTDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLAAENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLQEA
AVRQMLGSVDRSHVFRLIDALAQGDGRTVVETADTLRINGLSAASTLEDMSAVLQRMAVLQAVPQMAAAADASDPEAAEV
ARLSAALPADETQLLYSICLHGRADLGLAPDEYAALTMVLLRLLAFKPAASEGGAAASAEKKTLTRPEAAAPSAHAPADT
PVVQAPQAVPAAADRAPAPPVSVHPAPVEAPAMDCATAAPARPAASAAPTRAQATPDDVNQAVQEALDAGDRESPPWEAG
DTAQAPVRAAAPVRLPVRSPEDLRQKTPLAPAHTAQTAPETVAIPVRTAPEPGARLQPLPSAAPAPARLVRTEEGDVWHA
TVQQLIAQEAITALVRELALQSQLVARDPDHWLLRVERESLNQPTARERLRAALEAAGHARQISVEVGVVIDSPARRNAH
AAAERQRVAEEIVHNDPYVQQLMRDFGAKIVPGSIKPA
>Mature_677_residues
SYLVLARKYRPKTFSEMVGQEHVVQALSNALTQQRLHHAYLFTGTRGVGKTTVSRILAKSLNCQGPDGQGGITATPCGVC
PACTDIDSGRFPDYTELDAASNRGVDEVQGLLEQAVYKPVQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLAT
TDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTRVLAAENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLQEAA
VRQMLGSVDRSHVFRLIDALAQGDGRTVVETADTLRINGLSAASTLEDMSAVLQRMAVLQAVPQMAAAADASDPEAAEVA
RLSAALPADETQLLYSICLHGRADLGLAPDEYAALTMVLLRLLAFKPAASEGGAAASAEKKTLTRPEAAAPSAHAPADTP
VVQAPQAVPAAADRAPAPPVSVHPAPVEAPAMDCATAAPARPAASAAPTRAQATPDDVNQAVQEALDAGDRESPPWEAGD
TAQAPVRAAAPVRLPVRSPEDLRQKTPLAPAHTAQTAPETVAIPVRTAPEPGARLQPLPSAAPAPARLVRTEEGDVWHAT
VQQLIAQEAITALVRELALQSQLVARDPDHWLLRVERESLNQPTARERLRAALEAAGHARQISVEVGVVIDSPARRNAHA
AAERQRVAEEIVHNDPYVQQLMRDFGAKIVPGSIKPA

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=292, Percent_Identity=24.6575342465753, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI194306571, Length=295, Percent_Identity=24.406779661017, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI194306567, Length=295, Percent_Identity=24.406779661017, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI31563534, Length=254, Percent_Identity=25.9842519685039, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI194306569, Length=204, Percent_Identity=25.9803921568627, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1786676, Length=370, Percent_Identity=51.0810810810811, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1787341, Length=162, Percent_Identity=34.5679012345679, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=345, Percent_Identity=23.4782608695652, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=219, Percent_Identity=26.027397260274, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=299, Percent_Identity=24.4147157190635, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=255, Percent_Identity=24.3137254901961, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19921076, Length=296, Percent_Identity=25, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17647857, Length=261, Percent_Identity=27.2030651340996, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI18859927, Length=226, Percent_Identity=25.2212389380531, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 72113; Mature: 71981

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKYRPKTFSEMVGQEHVVQALSNALTQQRLHHAYLFTGTRGVGKTTVSRILAK
CCCEEEEHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
SLNCQGPDGQGGITATPCGVCPACTDIDSGRFPDYTELDAASNRGVDEVQGLLEQAVYKP
HCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
VQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
RPMAPETVLEHLTRVLAAENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLQEA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHH
AVRQMLGSVDRSHVFRLIDALAQGDGRTVVETADTLRINGLSAASTLEDMSAVLQRMAVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
QAVPQMAAAADASDPEAAEVARLSAALPADETQLLYSICLHGRADLGLAPDEYAALTMVL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRLLAFKPAASEGGAAASAEKKTLTRPEAAAPSAHAPADTPVVQAPQAVPAAADRAPAPP
HHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VSVHPAPVEAPAMDCATAAPARPAASAAPTRAQATPDDVNQAVQEALDAGDRESPPWEAG
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
DTAQAPVRAAAPVRLPVRSPEDLRQKTPLAPAHTAQTAPETVAIPVRTAPEPGARLQPLP
CCCCCCCCCCCCEECCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
SAAPAPARLVRTEEGDVWHATVQQLIAQEAITALVRELALQSQLVARDPDHWLLRVERES
CCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHH
LNQPTARERLRAALEAAGHARQISVEVGVVIDSPARRNAHAAAERQRVAEEIVHNDPYVQ
CCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHH
QLMRDFGAKIVPGSIKPA
HHHHHHCCEECCCCCCCC
>Mature Secondary Structure 
SYLVLARKYRPKTFSEMVGQEHVVQALSNALTQQRLHHAYLFTGTRGVGKTTVSRILAK
CCEEEEHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
SLNCQGPDGQGGITATPCGVCPACTDIDSGRFPDYTELDAASNRGVDEVQGLLEQAVYKP
HCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
VQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
RPMAPETVLEHLTRVLAAENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGSGQLQEA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHH
AVRQMLGSVDRSHVFRLIDALAQGDGRTVVETADTLRINGLSAASTLEDMSAVLQRMAVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
QAVPQMAAAADASDPEAAEVARLSAALPADETQLLYSICLHGRADLGLAPDEYAALTMVL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRLLAFKPAASEGGAAASAEKKTLTRPEAAAPSAHAPADTPVVQAPQAVPAAADRAPAPP
HHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VSVHPAPVEAPAMDCATAAPARPAASAAPTRAQATPDDVNQAVQEALDAGDRESPPWEAG
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
DTAQAPVRAAAPVRLPVRSPEDLRQKTPLAPAHTAQTAPETVAIPVRTAPEPGARLQPLP
CCCCCCCCCCCCEECCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
SAAPAPARLVRTEEGDVWHATVQQLIAQEAITALVRELALQSQLVARDPDHWLLRVERES
CCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHH
LNQPTARERLRAALEAAGHARQISVEVGVVIDSPARRNAHAAAERQRVAEEIVHNDPYVQ
CCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHH
QLMRDFGAKIVPGSIKPA
HHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]