Click here to switch to the map view.

The map label for this gene is carA [H]

Identifier: 222110654

GI number: 222110654

Start: 1523726

End: 1524898

Strand: Direct

Name: carA [H]

Synonym: Dtpsy_1456

Alternate gene names: 222110654

Gene position: 1523726-1524898 (Clockwise)

Preceding gene: 222110653

Following gene: 222110655

Centisome position: 40.13

GC content: 64.79

Gene sequence:

>1173_bases
GTGCTTTTGTCTCTCAAGGGAACCTTCCCGCCCGCCATCCTGGCGCTCGCAGACGGCACGGTCTTTATCGGTAACTCGAT
CGGTGCCGCCGGCACCACGGTCGGCGAAGTGGTCTTCAATACCGCCATCACCGGCTACCAGGAAATTCTCACGGACCCCA
GCTACTGCCAGCAGATCGTCACCCTGACGTATCCGCACATCGGCAACTACGGCGTCAACGCAGAGGATATCGAGGCTGAA
AAAGTCCACGCCGCAGGCCTCATCATCAAGGACCTGCCGCTGCTGGCCAGCAACTTCCGCATGACCGAGACGCTGCCCGA
GTACCTCGTGCGTGCCAAGACGGTGGCCATCGCCAACATCGACACCCGCAAACTGACCCGCCTGCTGCGCACCCAGGGCG
CGCAAAATGGCGCCATCGTCGGCTTGGCGGCTGGCGAGGCCGTGACCCAGGCGCGCATCGACGAAGCCGTGGCCGCGGCG
AAGGCGGCGCCCAACATGAACGGGCTGGATCTGGCCAAGGTCGTGACCACGCGTGCCGCGTACGCCTGGGACCAGACTGA
GTGGAAGCTGGGCGAAGGCTACGGCACGCAGACGGCCCCGCGCTTTCACGTCGTGGCCTATGACTATGGCGTGAAGCTGA
ACATCCTGCGCATGCTGGCCGAACGCGGCTGCAGGCTCACCGTGGTGCCCGCGCAGACCCCGGCGGCAGAGGTGCTGGCC
ATGAATCCCGATGGCGTGTTCCTGTCCAACGGCCCGGGCGACCCGGCGGCCTGCGACTACGCGATCACGGCAGTCAAGCA
GATCATCGACAGCGGCGTACCTACCTTCGGCATCTGCCTGGGCCACCAGATCATGGCGCTGGCCAGTGGCGCCAGGACTT
TCAAGATGGACAACAGCCACCATGGCGCAAACCACCCTGTGAAGGACTTGGACAGCGGCCGGGTAAGCATCACCAGCCAG
AACCACGGTTTCGCGGTGGACATGGCATCGCTGCCGGCCACCTTGCGCGCCACGCACATCAGCCTGTTCGACGGCACGCT
GCAGGGCCTGGAACACAAGGACAAGCCGGCCTTCTGTTTCCAGGGGCACCCCGAGGCGTCACCCGGTCCGCACGACATTG
CCTACCTGTTCGACCGCTTCACCACTCTGATGCAGGCCGCCAAGGCCCAGTAA

Upstream 100 bases:

>100_bases
CGCCCGGCCGCATCCAAAGCAATTTTCAACAAGCAGTAGCCTTCAGGAACATCGCCGTTCCTGCGGCTCCCGGGCGACCC
GTAAACCATCGGAGAACCCA

Downstream 100 bases:

>100_bases
GCCCAAAAGGAAACCGGCGCCATGAAACTCTTCAGCTTCCCGGCTGCAGCGCTTGAGAAAGCCATTCACAAGCGCGTGCT
GACATTGCCTCCAATGCACC

Product: carbamoyl-phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MLLSLKGTFPPAILALADGTVFIGNSIGAAGTTVGEVVFNTAITGYQEILTDPSYCQQIVTLTYPHIGNYGVNAEDIEAE
KVHAAGLIIKDLPLLASNFRMTETLPEYLVRAKTVAIANIDTRKLTRLLRTQGAQNGAIVGLAAGEAVTQARIDEAVAAA
KAAPNMNGLDLAKVVTTRAAYAWDQTEWKLGEGYGTQTAPRFHVVAYDYGVKLNILRMLAERGCRLTVVPAQTPAAEVLA
MNPDGVFLSNGPGDPAACDYAITAVKQIIDSGVPTFGICLGHQIMALASGARTFKMDNSHHGANHPVKDLDSGRVSITSQ
NHGFAVDMASLPATLRATHISLFDGTLQGLEHKDKPAFCFQGHPEASPGPHDIAYLFDRFTTLMQAAKAQ

Sequences:

>Translated_390_residues
MLLSLKGTFPPAILALADGTVFIGNSIGAAGTTVGEVVFNTAITGYQEILTDPSYCQQIVTLTYPHIGNYGVNAEDIEAE
KVHAAGLIIKDLPLLASNFRMTETLPEYLVRAKTVAIANIDTRKLTRLLRTQGAQNGAIVGLAAGEAVTQARIDEAVAAA
KAAPNMNGLDLAKVVTTRAAYAWDQTEWKLGEGYGTQTAPRFHVVAYDYGVKLNILRMLAERGCRLTVVPAQTPAAEVLA
MNPDGVFLSNGPGDPAACDYAITAVKQIIDSGVPTFGICLGHQIMALASGARTFKMDNSHHGANHPVKDLDSGRVSITSQ
NHGFAVDMASLPATLRATHISLFDGTLQGLEHKDKPAFCFQGHPEASPGPHDIAYLFDRFTTLMQAAKAQ
>Mature_390_residues
MLLSLKGTFPPAILALADGTVFIGNSIGAAGTTVGEVVFNTAITGYQEILTDPSYCQQIVTLTYPHIGNYGVNAEDIEAE
KVHAAGLIIKDLPLLASNFRMTETLPEYLVRAKTVAIANIDTRKLTRLLRTQGAQNGAIVGLAAGEAVTQARIDEAVAAA
KAAPNMNGLDLAKVVTTRAAYAWDQTEWKLGEGYGTQTAPRFHVVAYDYGVKLNILRMLAERGCRLTVVPAQTPAAEVLA
MNPDGVFLSNGPGDPAACDYAITAVKQIIDSGVPTFGICLGHQIMALASGARTFKMDNSHHGANHPVKDLDSGRVSITSQ
NHGFAVDMASLPATLRATHISLFDGTLQGLEHKDKPAFCFQGHPEASPGPHDIAYLFDRFTTLMQAAKAQ

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=389, Percent_Identity=37.7892030848329, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI169790915, Length=400, Percent_Identity=34.75, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI21361331, Length=400, Percent_Identity=34.75, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1786215, Length=377, Percent_Identity=64.4562334217507, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI193204318, Length=391, Percent_Identity=37.3401534526854, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324878, Length=396, Percent_Identity=36.1111111111111, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322331, Length=395, Percent_Identity=36.2025316455696, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322638, Length=173, Percent_Identity=27.7456647398844, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45555749, Length=391, Percent_Identity=38.618925831202, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24642586, Length=391, Percent_Identity=38.618925831202, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 41469; Mature: 41469

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSLKGTFPPAILALADGTVFIGNSIGAAGTTVGEVVFNTAITGYQEILTDPSYCQQIV
CEEECCCCCCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TLTYPHIGNYGVNAEDIEAEKVHAAGLIIKDLPLLASNFRMTETLPEYLVRAKTVAIANI
HHCCCCCCCCCCCCCCCCHHHHHHHCEEECCCHHHHCCCCHHHHHHHHHHHHHEEEEECC
DTRKLTRLLRTQGAQNGAIVGLAAGEAVTQARIDEAVAAAKAAPNMNGLDLAKVVTTRAA
CHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YAWDQTEWKLGEGYGTQTAPRFHVVAYDYGVKLNILRMLAERGCRLTVVPAQTPAAEVLA
HEECCCCEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCEEEE
MNPDGVFLSNGPGDPAACDYAITAVKQIIDSGVPTFGICLGHQIMALASGARTFKMDNSH
ECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
HGANHPVKDLDSGRVSITSQNHGFAVDMASLPATLRATHISLFDGTLQGLEHKDKPAFCF
CCCCCCCCCCCCCEEEEEECCCCEEEEHHHCCCCHHHEEEEEHHHHHHCCCCCCCCCEEE
QGHPEASPGPHDIAYLFDRFTTLMQAAKAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLSLKGTFPPAILALADGTVFIGNSIGAAGTTVGEVVFNTAITGYQEILTDPSYCQQIV
CEEECCCCCCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
TLTYPHIGNYGVNAEDIEAEKVHAAGLIIKDLPLLASNFRMTETLPEYLVRAKTVAIANI
HHCCCCCCCCCCCCCCCCHHHHHHHCEEECCCHHHHCCCCHHHHHHHHHHHHHEEEEECC
DTRKLTRLLRTQGAQNGAIVGLAAGEAVTQARIDEAVAAAKAAPNMNGLDLAKVVTTRAA
CHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YAWDQTEWKLGEGYGTQTAPRFHVVAYDYGVKLNILRMLAERGCRLTVVPAQTPAAEVLA
HEECCCCEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCCEEEE
MNPDGVFLSNGPGDPAACDYAITAVKQIIDSGVPTFGICLGHQIMALASGARTFKMDNSH
ECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
HGANHPVKDLDSGRVSITSQNHGFAVDMASLPATLRATHISLFDGTLQGLEHKDKPAFCF
CCCCCCCCCCCCCEEEEEECCCCEEEEHHHCCCCHHHEEEEEHHHHHHCCCCCCCCCEEE
QGHPEASPGPHDIAYLFDRFTTLMQAAKAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11343129 [H]