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The map label for this gene is gyaR [H]

Identifier: 222110570

GI number: 222110570

Start: 1432548

End: 1433528

Strand: Direct

Name: gyaR [H]

Synonym: Dtpsy_1370

Alternate gene names: 222110570

Gene position: 1432548-1433528 (Clockwise)

Preceding gene: 222110569

Following gene: 222110571

Centisome position: 37.73

GC content: 68.81

Gene sequence:

>981_bases
ATGTCCAAGCCCCACATCCTCGTCGCGCGCAAGATCTTTCCCGAGGTCATTGAGCGCCTGACGCAGCATTTCGAGGTGTA
TGCCAACCAGGACGACAACCTGTGGACGCAGGCCGAGCTCATCGAGCGGCTGCAGGGCAAGGACGGCGCGTTGCTCACCG
GCACCCAGCCGGTGAACGCCGAGCTGCTGGCCGCCTGCCCGCAGCTGCGCATCGCGGCCAACATGACGGTGGGCTACAAC
AACTTCGACATCGCCGCGATGACCGCCGCCGGCGTGCAGGGCACCAACACGCCCGACGTGCTGACCGAGACCACGGCCGA
TTTCGGCTTTGCGCTGCTCATGGCCACGGCGCGGCGCATCACGGAGAGCGAGCATTACCTGCGCGCCGGCCAGTGGACGC
GCTGGAGCTACGACATGTTCGCCGGCTGCGAGGTGCATGGCAGCACGCTGGGCATCCTGGGCATGGGCCGCATCGGGCAG
GGCATTGCCAAGCGTGGGGCGCATGGCTTTGGCATGAACGTGATCTACCACAACCGCTCGCGCCTGTCGCCCGCGCTGGA
GGCCGAATGCAAGGCGCGTTACGTGGGCAAGGACGAGCTGCTGGCCCAGGCCGACCACCTGGTGCTGGTGCTGCCCTACA
CGCCCGAGTCGCACCACGCCATCGGCGCGGCCGAGATCGCGCGCATGAAGCCCACGGCCACGCTGATCAACATCGCGCGC
GGCGGCATCGTTGATGACGCGGCGCTGGCCCAGGCGCTCAAGGAGCGCCGCATCGCTGCCGCGGGGCTGGACGTGTTCGA
AGGCGAGCCCGCGGTGCACCCCGCGTTGCTGGAGGTGCCCAACGTGGTGCTCACCCCGCACATCGCCAGCGCCACCGTGC
CCACGCGGCTCGCCATGGCGCAACTGGCGGCGGACAACCTGGTGGCGTTCTTCGACGGGCGCGGTGCCCTCACTCCCGTG
AACACGCCCGCCAAGGTGTGA

Upstream 100 bases:

>100_bases
ACCTTCATCTGGTTGCAATGAGCCCGGGCCTGAACCGCGGGGTGCCTCGGCACGGCCCCGCGTTCAGGCTGCCGACACCT
GACCGAAAGGAGCACTTCCC

Downstream 100 bases:

>100_bases
ATGAAATTGGCCTCTGGCGCTTGATGGACAAGCGCTAACAGCTATTGTTTTGATAGTTCAAGAATGACATTCGAAATGAC
CGCCGCACTGGCGTTGCTGG

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSKPHILVARKIFPEVIERLTQHFEVYANQDDNLWTQAELIERLQGKDGALLTGTQPVNAELLAACPQLRIAANMTVGYN
NFDIAAMTAAGVQGTNTPDVLTETTADFGFALLMATARRITESEHYLRAGQWTRWSYDMFAGCEVHGSTLGILGMGRIGQ
GIAKRGAHGFGMNVIYHNRSRLSPALEAECKARYVGKDELLAQADHLVLVLPYTPESHHAIGAAEIARMKPTATLINIAR
GGIVDDAALAQALKERRIAAAGLDVFEGEPAVHPALLEVPNVVLTPHIASATVPTRLAMAQLAADNLVAFFDGRGALTPV
NTPAKV

Sequences:

>Translated_326_residues
MSKPHILVARKIFPEVIERLTQHFEVYANQDDNLWTQAELIERLQGKDGALLTGTQPVNAELLAACPQLRIAANMTVGYN
NFDIAAMTAAGVQGTNTPDVLTETTADFGFALLMATARRITESEHYLRAGQWTRWSYDMFAGCEVHGSTLGILGMGRIGQ
GIAKRGAHGFGMNVIYHNRSRLSPALEAECKARYVGKDELLAQADHLVLVLPYTPESHHAIGAAEIARMKPTATLINIAR
GGIVDDAALAQALKERRIAAAGLDVFEGEPAVHPALLEVPNVVLTPHIASATVPTRLAMAQLAADNLVAFFDGRGALTPV
NTPAKV
>Mature_325_residues
SKPHILVARKIFPEVIERLTQHFEVYANQDDNLWTQAELIERLQGKDGALLTGTQPVNAELLAACPQLRIAANMTVGYNN
FDIAAMTAAGVQGTNTPDVLTETTADFGFALLMATARRITESEHYLRAGQWTRWSYDMFAGCEVHGSTLGILGMGRIGQG
IAKRGAHGFGMNVIYHNRSRLSPALEAECKARYVGKDELLAQADHLVLVLPYTPESHHAIGAAEIARMKPTATLINIARG
GIVDDAALAQALKERRIAAAGLDVFEGEPAVHPALLEVPNVVLTPHIASATVPTRLAMAQLAADNLVAFFDGRGALTPVN
TPAKV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=292, Percent_Identity=38.013698630137, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI23308577, Length=320, Percent_Identity=29.375, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=34.7985347985348, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=34.7985347985348, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580578, Length=273, Percent_Identity=35.1648351648352, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557499, Length=273, Percent_Identity=35.1648351648352, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=35.7664233576642, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=42.6791277258567, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789279, Length=268, Percent_Identity=30.2238805970149, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=271, Percent_Identity=29.1512915129151, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081824, Length=152, Percent_Identity=34.2105263157895, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=30.9148264984227, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=278, Percent_Identity=26.6187050359712, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=298, Percent_Identity=32.8859060402685, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320925, Length=302, Percent_Identity=29.4701986754967, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=302, Percent_Identity=28.8079470198675, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321253, Length=174, Percent_Identity=30.4597701149425, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=38.0191693290735, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=38.0191693290735, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=38.0191693290735, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=38.0191693290735, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=38.0191693290735, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI28571528, Length=299, Percent_Identity=40.133779264214, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574286, Length=323, Percent_Identity=35.9133126934984, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24585516, Length=286, Percent_Identity=32.5174825174825, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI19921140, Length=313, Percent_Identity=30.0319488817891, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=34.3511450381679, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=34.3511450381679, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=34.3511450381679, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=34.3511450381679, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=34.3511450381679, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35075; Mature: 34943

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPHILVARKIFPEVIERLTQHFEVYANQDDNLWTQAELIERLQGKDGALLTGTQPVNA
CCCCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCH
ELLAACPQLRIAANMTVGYNNFDIAAMTAAGVQGTNTPDVLTETTADFGFALLMATARRI
HHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TESEHYLRAGQWTRWSYDMFAGCEVHGSTLGILGMGRIGQGIAKRGAHGFGMNVIYHNRS
HCCHHHHHCCCCEEECHHHEECCEECCCEEEEEECCHHHHHHHHCCCCCCCEEEEEECHH
RLSPALEAECKARYVGKDELLAQADHLVLVLPYTPESHHAIGAAEIARMKPTATLINIAR
HCCHHHHHHHHHEECCHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHC
GGIVDDAALAQALKERRIAAAGLDVFEGEPAVHPALLEVPNVVLTPHIASATVPTRLAMA
CCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHCCCEEECCCCCCCCHHHHHHHH
QLAADNLVAFFDGRGALTPVNTPAKV
HHHHCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKPHILVARKIFPEVIERLTQHFEVYANQDDNLWTQAELIERLQGKDGALLTGTQPVNA
CCCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCH
ELLAACPQLRIAANMTVGYNNFDIAAMTAAGVQGTNTPDVLTETTADFGFALLMATARRI
HHHHHCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TESEHYLRAGQWTRWSYDMFAGCEVHGSTLGILGMGRIGQGIAKRGAHGFGMNVIYHNRS
HCCHHHHHCCCCEEECHHHEECCEECCCEEEEEECCHHHHHHHHCCCCCCCEEEEEECHH
RLSPALEAECKARYVGKDELLAQADHLVLVLPYTPESHHAIGAAEIARMKPTATLINIAR
HCCHHHHHHHHHEECCHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHC
GGIVDDAALAQALKERRIAAAGLDVFEGEPAVHPALLEVPNVVLTPHIASATVPTRLAMA
CCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHCCCEEECCCCCCCCHHHHHHHH
QLAADNLVAFFDGRGALTPVNTPAKV
HHHHCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA