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The map label for this gene is paaF [C]

Identifier: 222110455

GI number: 222110455

Start: 1316779

End: 1317870

Strand: Direct

Name: paaF [C]

Synonym: Dtpsy_1252

Alternate gene names: 222110455

Gene position: 1316779-1317870 (Clockwise)

Preceding gene: 222110454

Following gene: 222110460

Centisome position: 34.68

GC content: 66.85

Gene sequence:

>1092_bases
ATGACGGAGATGACGGCGGAAGTCGTGACCGAGGTGCGCGGCCAGGTCGGCTGCATCACGCTGAACCGCCCGAAGGCGCT
GAATGCCTTGTCGCTGGGCATGGTGCGCGACCTGATGGCGGCGCTGCTGGCCTGGCAGCATGACGACAAGGTACTGGCCG
TGGCGATCCGCGGCAACGGTCGCGAAGGGCCCTTCGGCGCCTTCTGCGCGGGCGGCGACATCCGCTTCTTGCACGCCGCG
GGCAGCACGGGCAATCCGCAACTGGAGGACTTCTTCACCGAGGAATACGCCCTCAACCATCTGATCCACACCTTCGGCAA
GCCCTACATCGCCTTCATGGACGGCATCGTCATGGGGGGCGGCATGGGCATCAGCCAGGGCGGCACGCTGCGCATCGTGA
CCGAGCGCACCAAGATGGCCATGCCGGAGACGGCGATCGGCCTGTTCCCCGATGTGGGCGGCGGCTACTTTCTCTCGCGC
TGTCCTGGCCGCGTGGGCGAGTGGCTGGCACTGACGGGCGACGCCATCGGTGCAGCCGATGCCATTGACTTCGGCCTGGC
GGACGGCTTCCTGCCAGCGGACCAGCAAGCGGCGGTGTGGGACGGTCTGGCGTTGCAGACGTTTGCCGACGGCGCTGCCG
TTCAGCAGTGGGTTGCATCAAAATTTGTAGCTGCTGGCGCTTGCGCTGTAAGCGCTAGAGGCCAAATTGATCACTACTTC
GCGTTGGATGATGCGGCGGCCATCGTGGCTGCGCTGGAGCAGTCTGACGACGAGTGGGCACGCGCCACGGCTGCCACGTT
GCGCAAGCGCTCTCCACTGATGCTGCATGTCGTGCTGGAGCAGGTCCGCCGTGCGCGCAGCATGGGTCTGGCCGACGACT
TGCGCATGGAGCGCGACATGGTTCGGCACTGCTTCTACCTGCGTCCCGACCAGAGCGAGACGGTGGAGGGCATTCGCGCC
CTGGCGGTGGACAAGGACCACAGCCCGCGCTGGAACCCCGCGCGCGTGGAGGATGTGGAGCCCGCGCTGGTGCAATCGTT
CTTCAAGAGCCCTTGGCCGGCGCACGCGCACCCGCTGGCGGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
TGGGCGCTGGAGAGCGCCCAGCCCCGGCCGTGCTGATGGGAGGCGCGCTGGTGATCGGCGCGCTCGTTTTCAATGAACTG
CTTGGATGGAAGGAACAACA

Downstream 100 bases:

>100_bases
TTTGCTGGTACACCGCCGTGGCCAGCGCCTGCAGCGTGGGCCGCGGCAGTTCGCCGCTGAGGGCGTAGCCAAAACCCTGG
TCCACCCAGTAGAAACTGGA

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTEMTAEVVTEVRGQVGCITLNRPKALNALSLGMVRDLMAALLAWQHDDKVLAVAIRGNGREGPFGAFCAGGDIRFLHAA
GSTGNPQLEDFFTEEYALNHLIHTFGKPYIAFMDGIVMGGGMGISQGGTLRIVTERTKMAMPETAIGLFPDVGGGYFLSR
CPGRVGEWLALTGDAIGAADAIDFGLADGFLPADQQAAVWDGLALQTFADGAAVQQWVASKFVAAGACAVSARGQIDHYF
ALDDAAAIVAALEQSDDEWARATAATLRKRSPLMLHVVLEQVRRARSMGLADDLRMERDMVRHCFYLRPDQSETVEGIRA
LAVDKDHSPRWNPARVEDVEPALVQSFFKSPWPAHAHPLAALR

Sequences:

>Translated_363_residues
MTEMTAEVVTEVRGQVGCITLNRPKALNALSLGMVRDLMAALLAWQHDDKVLAVAIRGNGREGPFGAFCAGGDIRFLHAA
GSTGNPQLEDFFTEEYALNHLIHTFGKPYIAFMDGIVMGGGMGISQGGTLRIVTERTKMAMPETAIGLFPDVGGGYFLSR
CPGRVGEWLALTGDAIGAADAIDFGLADGFLPADQQAAVWDGLALQTFADGAAVQQWVASKFVAAGACAVSARGQIDHYF
ALDDAAAIVAALEQSDDEWARATAATLRKRSPLMLHVVLEQVRRARSMGLADDLRMERDMVRHCFYLRPDQSETVEGIRA
LAVDKDHSPRWNPARVEDVEPALVQSFFKSPWPAHAHPLAALR
>Mature_362_residues
TEMTAEVVTEVRGQVGCITLNRPKALNALSLGMVRDLMAALLAWQHDDKVLAVAIRGNGREGPFGAFCAGGDIRFLHAAG
STGNPQLEDFFTEEYALNHLIHTFGKPYIAFMDGIVMGGGMGISQGGTLRIVTERTKMAMPETAIGLFPDVGGGYFLSRC
PGRVGEWLALTGDAIGAADAIDFGLADGFLPADQQAAVWDGLALQTFADGAAVQQWVASKFVAAGACAVSARGQIDHYFA
LDDAAAIVAALEQSDDEWARATAATLRKRSPLMLHVVLEQVRRARSMGLADDLRMERDMVRHCFYLRPDQSETVEGIRAL
AVDKDHSPRWNPARVEDVEPALVQSFFKSPWPAHAHPLAALR

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=355, Percent_Identity=36.3380281690141, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI37594469, Length=311, Percent_Identity=36.3344051446945, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI194097323, Length=193, Percent_Identity=34.1968911917098, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787659, Length=195, Percent_Identity=28.7179487179487, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI221142681, Length=177, Percent_Identity=27.683615819209, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25144157, Length=359, Percent_Identity=40.1114206128134, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI25144160, Length=359, Percent_Identity=40.1114206128134, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17554946, Length=185, Percent_Identity=31.3513513513514, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=182, Percent_Identity=31.3186813186813, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320241, Length=207, Percent_Identity=38.6473429951691, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI28571730, Length=351, Percent_Identity=39.031339031339, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28571729, Length=351, Percent_Identity=39.031339031339, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI20129971, Length=192, Percent_Identity=34.8958333333333, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653477, Length=192, Percent_Identity=34.8958333333333, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653139, Length=208, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 39176; Mature: 39045

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEMTAEVVTEVRGQVGCITLNRPKALNALSLGMVRDLMAALLAWQHDDKVLAVAIRGNG
CCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
REGPFGAFCAGGDIRFLHAAGSTGNPQLEDFFTEEYALNHLIHTFGKPYIAFMDGIVMGG
CCCCCCEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
GMGISQGGTLRIVTERTKMAMPETAIGLFPDVGGGYFLSRCPGRVGEWLALTGDAIGAAD
CCCCCCCCEEEEEECCHHHCCCCHHHCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCHH
AIDFGLADGFLPADQQAAVWDGLALQTFADGAAVQQWVASKFVAAGACAVSARGQIDHYF
HHHHHCCCCCCCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEE
ALDDAAAIVAALEQSDDEWARATAATLRKRSPLMLHVVLEQVRRARSMGLADDLRMERDM
EHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VRHCFYLRPDQSETVEGIRALAVDKDHSPRWNPARVEDVEPALVQSFFKSPWPAHAHPLA
HHHHEECCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
ALR
HCC
>Mature Secondary Structure 
TEMTAEVVTEVRGQVGCITLNRPKALNALSLGMVRDLMAALLAWQHDDKVLAVAIRGNG
CCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
REGPFGAFCAGGDIRFLHAAGSTGNPQLEDFFTEEYALNHLIHTFGKPYIAFMDGIVMGG
CCCCCCEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
GMGISQGGTLRIVTERTKMAMPETAIGLFPDVGGGYFLSRCPGRVGEWLALTGDAIGAAD
CCCCCCCCEEEEEECCHHHCCCCHHHCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCCHH
AIDFGLADGFLPADQQAAVWDGLALQTFADGAAVQQWVASKFVAAGACAVSARGQIDHYF
HHHHHCCCCCCCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEE
ALDDAAAIVAALEQSDDEWARATAATLRKRSPLMLHVVLEQVRRARSMGLADDLRMERDM
EHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VRHCFYLRPDQSETVEGIRALAVDKDHSPRWNPARVEDVEPALVQSFFKSPWPAHAHPLA
HHHHEECCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
ALR
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA