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The map label for this gene is lpxB [H]

Identifier: 222110439

GI number: 222110439

Start: 1298296

End: 1299453

Strand: Direct

Name: lpxB [H]

Synonym: Dtpsy_1236

Alternate gene names: 222110439

Gene position: 1298296-1299453 (Clockwise)

Preceding gene: 222110438

Following gene: 222110440

Centisome position: 34.2

GC content: 66.32

Gene sequence:

>1158_bases
ATGGTGGCTGAGTCTCCCCGCGTCGCAATGGTGGCTGGCGAAACCTCTGGCGACCTGCTGGCCGGCCTGCTGCTGGACGG
CCTGCGTGCGCGGTGGCCCGCCGTGGCCAGTATGGGCATCGGCGGGCCGCGCATGCAGGAGCGGGGCTTTCAGGCCTGGT
GGCCCAGCGAACGGCTGGCCGTGCACGGCTACAGCGTCGAGCTGGTGCGGCGCCTGCTGGGCATTCTGCGGATCCGCCGG
CAGCTGCGTGCCAGATTGCTGGCGGACAAGCCCGACGTCTTCATCGGCGTGGATGCGCCCGATTTCAACCTGGGGTTGGA
GGCGGACCTGCGTGCCGCCGGCATAAAGACGGTGCACTTCGTCTGCCCTTCGATCTGGGCGTGGCGCGCCGATCGGGTCG
AGAAGATTCGTTCCAGCGCGGACCATGTCCTGTGCATCTTTCCGTTTGAGCCGAAACTGCTCGCGCGCCAGGGCATCGCC
GCCACCTATGTCGGCCACCCATTGGCCAGTGTCATCCCCCGGGTGCCCGACAAGGCGGCTGCGCGCGCACAGCTGGGCCT
GACGGTACACGATGAAGTGCTGGCCATCCTGCCGGGCAGTCGCTCGGCAGAGGTGGCCTACATTGCCAAGCCGTTCTTTC
AGGCTGCAGCGCTTATCAAAAAAGCGCGACCAGCTATAAAAATAGTAGTACCCGCGGTGCCGGCCCTGAGGGCTCGTATC
GAGCAGATCGCGCGCGAATGCGGGGTGCTGGATGCGCTGACCATCGTCACGGGCCAATCGCACCTGGTGCTCGCGGCCTG
CGACGTGACGCTGATTGCCAGTGGCACCGCCACGCTGGAGGCCGCGCTGTTCAAGCGGCCGATGGTCATCTCCTACCACA
TGCATCCGATCAGTTGGCGCCTCATGCGCCGCAAGCAGTTGCAGCCCTGGGTGGGCTTGCCCAACATCCTGTGCAGGGAG
TTCGTGGTGCCCGAGCTGTTGCAGGACGCCGCCACGCCCGACGCACTGGCCACCGCGGTCCAGGACTGGCTGGACGCGCG
GTTGCAGGATCCGGCCCGTATCCAACGGCTGGAACAGCGCTTCACGGCATTGCACGACGATCTGCAGCGCGATACCCCGC
GACTGGCTGCCCATGCGATCCAGAACCTCCTTGCTTGA

Upstream 100 bases:

>100_bases
GCCGCATTCGCATCCCGAGGCGGAAGGCGATATCGCCCTGCTGCGTGATTTCGTGATCGCGTCTCAGCGCGGTATCGCGC
GCTGAGACGCCGCTGGCGCC

Downstream 100 bases:

>100_bases
GCAGGCCGCCCTGGACTGGCATCCGCCCGGCCTCGTCGCCGGCGTGGATGAGGCCGGGCGTGGGCCGTTGGCCGGCCCCG
TGGTGGCGGCTGCGGTGATC

Product: lipid-a-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MVAESPRVAMVAGETSGDLLAGLLLDGLRARWPAVASMGIGGPRMQERGFQAWWPSERLAVHGYSVELVRRLLGILRIRR
QLRARLLADKPDVFIGVDAPDFNLGLEADLRAAGIKTVHFVCPSIWAWRADRVEKIRSSADHVLCIFPFEPKLLARQGIA
ATYVGHPLASVIPRVPDKAAARAQLGLTVHDEVLAILPGSRSAEVAYIAKPFFQAAALIKKARPAIKIVVPAVPALRARI
EQIARECGVLDALTIVTGQSHLVLAACDVTLIASGTATLEAALFKRPMVISYHMHPISWRLMRRKQLQPWVGLPNILCRE
FVVPELLQDAATPDALATAVQDWLDARLQDPARIQRLEQRFTALHDDLQRDTPRLAAHAIQNLLA

Sequences:

>Translated_385_residues
MVAESPRVAMVAGETSGDLLAGLLLDGLRARWPAVASMGIGGPRMQERGFQAWWPSERLAVHGYSVELVRRLLGILRIRR
QLRARLLADKPDVFIGVDAPDFNLGLEADLRAAGIKTVHFVCPSIWAWRADRVEKIRSSADHVLCIFPFEPKLLARQGIA
ATYVGHPLASVIPRVPDKAAARAQLGLTVHDEVLAILPGSRSAEVAYIAKPFFQAAALIKKARPAIKIVVPAVPALRARI
EQIARECGVLDALTIVTGQSHLVLAACDVTLIASGTATLEAALFKRPMVISYHMHPISWRLMRRKQLQPWVGLPNILCRE
FVVPELLQDAATPDALATAVQDWLDARLQDPARIQRLEQRFTALHDDLQRDTPRLAAHAIQNLLA
>Mature_385_residues
MVAESPRVAMVAGETSGDLLAGLLLDGLRARWPAVASMGIGGPRMQERGFQAWWPSERLAVHGYSVELVRRLLGILRIRR
QLRARLLADKPDVFIGVDAPDFNLGLEADLRAAGIKTVHFVCPSIWAWRADRVEKIRSSADHVLCIFPFEPKLLARQGIA
ATYVGHPLASVIPRVPDKAAARAQLGLTVHDEVLAILPGSRSAEVAYIAKPFFQAAALIKKARPAIKIVVPAVPALRARI
EQIARECGVLDALTIVTGQSHLVLAACDVTLIASGTATLEAALFKRPMVISYHMHPISWRLMRRKQLQPWVGLPNILCRE
FVVPELLQDAATPDALATAVQDWLDARLQDPARIQRLEQRFTALHDDLQRDTPRLAAHAIQNLLA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=327, Percent_Identity=43.1192660550459, Blast_Score=260, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42324; Mature: 42324

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAESPRVAMVAGETSGDLLAGLLLDGLRARWPAVASMGIGGPRMQERGFQAWWPSERLA
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCCCCCCCCCEE
VHGYSVELVRRLLGILRIRRQLRARLLADKPDVFIGVDAPDFNLGLEADLRAAGIKTVHF
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHH
VCPSIWAWRADRVEKIRSSADHVLCIFPFEPKLLARQGIAATYVGHPLASVIPRVPDKAA
HHCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCHHHHHCCCHHHHHCCCCCHHH
ARAQLGLTVHDEVLAILPGSRSAEVAYIAKPFFQAAALIKKARPAIKIVVPAVPALRARI
HHHHCCCEECCCCCEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
EQIARECGVLDALTIVTGQSHLVLAACDVTLIASGTATLEAALFKRPMVISYHMHPISWR
HHHHHHCCCHHHHHEEECCCCEEEEEECEEEEECCCHHHHHHHHCCCEEEEEECCCHHHH
LMRRKQLQPWVGLPNILCREFVVPELLQDAATPDALATAVQDWLDARLQDPARIQRLEQR
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FTALHDDLQRDTPRLAAHAIQNLLA
HHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVAESPRVAMVAGETSGDLLAGLLLDGLRARWPAVASMGIGGPRMQERGFQAWWPSERLA
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCCCCCCCCCEE
VHGYSVELVRRLLGILRIRRQLRARLLADKPDVFIGVDAPDFNLGLEADLRAAGIKTVHF
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHH
VCPSIWAWRADRVEKIRSSADHVLCIFPFEPKLLARQGIAATYVGHPLASVIPRVPDKAA
HHCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCHHHHHCCCHHHHHCCCCCHHH
ARAQLGLTVHDEVLAILPGSRSAEVAYIAKPFFQAAALIKKARPAIKIVVPAVPALRARI
HHHHCCCEECCCCCEECCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
EQIARECGVLDALTIVTGQSHLVLAACDVTLIASGTATLEAALFKRPMVISYHMHPISWR
HHHHHHCCCHHHHHEEECCCCEEEEEECEEEEECCCHHHHHHHHCCCEEEEEECCCHHHH
LMRRKQLQPWVGLPNILCREFVVPELLQDAATPDALATAVQDWLDARLQDPARIQRLEQR
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FTALHDDLQRDTPRLAAHAIQNLLA
HHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA