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The map label for this gene is lpxA [H]

Identifier: 222110438

GI number: 222110438

Start: 1297489

End: 1298280

Strand: Direct

Name: lpxA [H]

Synonym: Dtpsy_1235

Alternate gene names: 222110438

Gene position: 1297489-1298280 (Clockwise)

Preceding gene: 222110437

Following gene: 222110439

Centisome position: 34.18

GC content: 65.03

Gene sequence:

>792_bases
TTGGCGCCCAACATCCATTCCACGGCCCTCGTTGATGCGGCCGCGCAGTTGGACCCTACTGTTACGGTGGGGCCGTATGC
GGTTATCGGCCCCCACGTGCAAATCGGCGCGCACACGTCGATTGGCGCGCACTGCGTGATCGAGGGCCATACACGCATTG
GCGAAGACAACCGCATCTTCCAGTTCAGTTCGCTGGGAGCAGCTCCGCAGGACAAGAAATACGCGGGCGAGCCCACGCGT
TTGGAGATCGGCCACCGCAACACGATCCGCGAGTTCTGCACCTTCAACGTCGGGACCGTGCAGGACCGGGGCGTCACCTC
CATCGGGGACGACAACTGGATCATGGCCTATGTGCACATCGCGCACGACTGCGTGGTGGGCAACCAGACCATCCTGGCCA
ACAACGCCACGCTGGCCGGACATGTGCAGGTGGGTGACCAGGCCATCATCGGCGGCTTGACCGGCGTGCACCAGTTTTCA
CGCATCGGCGCCCACGTCATGGCGGGCTTTGCCAGCCGCATCTCGCAAGATGTTCCGCCCTTCATGATGGTGGACGGCAA
TCCGCTGGCCGTGCGCGGGCTGAACCTGGAAGGGCTGCGCCGACGGGGTTTTTCCGCGCAGCGCATGGCGGGCATCAAGC
AGGCCTACCGCCTCCTGTACCGCCAGGGCCTCACGCTGGAGGCCGCGCTGTCGGCCATGGCCGACGTGCCGCATTCGCAT
CCCGAGGCGGAAGGCGATATCGCCCTGCTGCGTGATTTCGTGATCGCGTCTCAGCGCGGTATCGCGCGCTGA

Upstream 100 bases:

>100_bases
ACAAGTTCAAGGGCGTCGCGCGCGTGGGCGACAGCGTCGCGTGCGAGGCCGAGATCATGTGCACCATGCGCACGGTGGCC
TGACGGGCCGAGGATTTCGC

Downstream 100 bases:

>100_bases
GACGCCGCTGGCGCCATGGTGGCTGAGTCTCCCCGCGTCGCAATGGTGGCTGGCGAAACCTCTGGCGACCTGCTGGCCGG
CCTGCTGCTGGACGGCCTGC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAPNIHSTALVDAAAQLDPTVTVGPYAVIGPHVQIGAHTSIGAHCVIEGHTRIGEDNRIFQFSSLGAAPQDKKYAGEPTR
LEIGHRNTIREFCTFNVGTVQDRGVTSIGDDNWIMAYVHIAHDCVVGNQTILANNATLAGHVQVGDQAIIGGLTGVHQFS
RIGAHVMAGFASRISQDVPPFMMVDGNPLAVRGLNLEGLRRRGFSAQRMAGIKQAYRLLYRQGLTLEAALSAMADVPHSH
PEAEGDIALLRDFVIASQRGIAR

Sequences:

>Translated_263_residues
MAPNIHSTALVDAAAQLDPTVTVGPYAVIGPHVQIGAHTSIGAHCVIEGHTRIGEDNRIFQFSSLGAAPQDKKYAGEPTR
LEIGHRNTIREFCTFNVGTVQDRGVTSIGDDNWIMAYVHIAHDCVVGNQTILANNATLAGHVQVGDQAIIGGLTGVHQFS
RIGAHVMAGFASRISQDVPPFMMVDGNPLAVRGLNLEGLRRRGFSAQRMAGIKQAYRLLYRQGLTLEAALSAMADVPHSH
PEAEGDIALLRDFVIASQRGIAR
>Mature_262_residues
APNIHSTALVDAAAQLDPTVTVGPYAVIGPHVQIGAHTSIGAHCVIEGHTRIGEDNRIFQFSSLGAAPQDKKYAGEPTRL
EIGHRNTIREFCTFNVGTVQDRGVTSIGDDNWIMAYVHIAHDCVVGNQTILANNATLAGHVQVGDQAIIGGLTGVHQFSR
IGAHVMAGFASRISQDVPPFMMVDGNPLAVRGLNLEGLRRRGFSAQRMAGIKQAYRLLYRQGLTLEAALSAMADVPHSHP
EAEGDIALLRDFVIASQRGIAR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=259, Percent_Identity=51.3513513513513, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1786376, Length=242, Percent_Identity=25.6198347107438, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28155; Mature: 28024

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPNIHSTALVDAAAQLDPTVTVGPYAVIGPHVQIGAHTSIGAHCVIEGHTRIGEDNRIF
CCCCCCHHHHHHHHHHCCCCEEECCEEEECCEEEECCCCCCCEEEEEECCCEECCCCCEE
QFSSLGAAPQDKKYAGEPTRLEIGHRNTIREFCTFNVGTVQDRGVTSIGDDNWIMAYVHI
EECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEE
AHDCVVGNQTILANNATLAGHVQVGDQAIIGGLTGVHQFSRIGAHVMAGFASRISQDVPP
HHHEEECCCEEEECCCEEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FMMVDGNPLAVRGLNLEGLRRRGFSAQRMAGIKQAYRLLYRQGLTLEAALSAMADVPHSH
EEEECCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
PEAEGDIALLRDFVIASQRGIAR
CCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
APNIHSTALVDAAAQLDPTVTVGPYAVIGPHVQIGAHTSIGAHCVIEGHTRIGEDNRIF
CCCCCHHHHHHHHHHCCCCEEECCEEEECCEEEECCCCCCCEEEEEECCCEECCCCCEE
QFSSLGAAPQDKKYAGEPTRLEIGHRNTIREFCTFNVGTVQDRGVTSIGDDNWIMAYVHI
EECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEE
AHDCVVGNQTILANNATLAGHVQVGDQAIIGGLTGVHQFSRIGAHVMAGFASRISQDVPP
HHHEEECCCEEEECCCEEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FMMVDGNPLAVRGLNLEGLRRRGFSAQRMAGIKQAYRLLYRQGLTLEAALSAMADVPHSH
EEEECCCEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
PEAEGDIALLRDFVIASQRGIAR
CCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA