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The map label for this gene is uppS [H]

Identifier: 222110430

GI number: 222110430

Start: 1288872

End: 1289606

Strand: Direct

Name: uppS [H]

Synonym: Dtpsy_1227

Alternate gene names: 222110430

Gene position: 1288872-1289606 (Clockwise)

Preceding gene: 222110429

Following gene: 222110431

Centisome position: 33.95

GC content: 66.8

Gene sequence:

>735_bases
ATGCCCACCGTGCAGGGAGCCATTCCCCACCACATTGCCATCGTCATGGATGGCAACGGCCGCTGGGCGACGCGCCGCTT
CCTGCCGCGCCTGGCGGGGCATCGGCAGGGCGTGGAATCGCTGCGGCGCTGCGTGCATGCTTGCGTCCAACGCGGCGTGG
GCGTGCTTACCGTGTTCGCGTTTTCCTCCGAGAACTGGAACCGTCCGGCGGACGAGGTGTCCGGTCTCATGGATCTGCTT
GCCAAGGCGCTGACACGTGAGGTGCCGCAACTGGCCCGGGATGGCGTGCAGGTGCACTTCGTGGGGGAAAAGTCGGGCAT
TTCGGCGCAGGTGCGCGAAGGGCTCCAGCGTGCCGAGGCGGCCACCGCAAGCAACCAGCGACTGGTGCTCAATGTCTGCT
TCAACTACGGCGGCCGTTGGGACATCACGCAGGCCGCAGCTGCGCTTGCAGCGCGGGGCGAGCCCATCACCGAGGCCAGC
CTGCATGCCGCCATGGGCATGGCCCATGTGCCCGATCCGGATCTGCTGATCCGAACCGGTGGCGAGCGGCGCATCAGCAA
CTTCCTGCTGTGGCAGGCCGCCTATACCGAACTGTATTTCAGTGACCGCCTGTGGCCCGATTTCGACGAGGCCGCACTGG
ATGAAGCCATCGCGGACTTCGCGGCGCGCGAGCGCCGCTTTGGCCAAACCTCCGACCAGGTACAAGCGCAGCAGCCCGGT
TCGCTGCGTGCCTGA

Upstream 100 bases:

>100_bases
ACCACCGACAAGCACATTGCAGAGATCGATGCCTTGGTGGCGGCCAAGGAGCAGGAAATCATGGCGATCTGATCCGGTTT
TGCGGATCGATCCTGGATTC

Downstream 100 bases:

>100_bases
TTCCGTCCACCGCACATCGCTGAAGGGGTCTGGATGCTCAAGCAACGTGTCATCACCGCGTTGGTCCTGCTGGCCATTCT
GTTGCCGGCATTGTTCTATC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MPTVQGAIPHHIAIVMDGNGRWATRRFLPRLAGHRQGVESLRRCVHACVQRGVGVLTVFAFSSENWNRPADEVSGLMDLL
AKALTREVPQLARDGVQVHFVGEKSGISAQVREGLQRAEAATASNQRLVLNVCFNYGGRWDITQAAAALAARGEPITEAS
LHAAMGMAHVPDPDLLIRTGGERRISNFLLWQAAYTELYFSDRLWPDFDEAALDEAIADFAARERRFGQTSDQVQAQQPG
SLRA

Sequences:

>Translated_244_residues
MPTVQGAIPHHIAIVMDGNGRWATRRFLPRLAGHRQGVESLRRCVHACVQRGVGVLTVFAFSSENWNRPADEVSGLMDLL
AKALTREVPQLARDGVQVHFVGEKSGISAQVREGLQRAEAATASNQRLVLNVCFNYGGRWDITQAAAALAARGEPITEAS
LHAAMGMAHVPDPDLLIRTGGERRISNFLLWQAAYTELYFSDRLWPDFDEAALDEAIADFAARERRFGQTSDQVQAQQPG
SLRA
>Mature_243_residues
PTVQGAIPHHIAIVMDGNGRWATRRFLPRLAGHRQGVESLRRCVHACVQRGVGVLTVFAFSSENWNRPADEVSGLMDLLA
KALTREVPQLARDGVQVHFVGEKSGISAQVREGLQRAEAATASNQRLVLNVCFNYGGRWDITQAAAALAARGEPITEASL
HAAMGMAHVPDPDLLIRTGGERRISNFLLWQAAYTELYFSDRLWPDFDEAALDEAIADFAARERRFGQTSDQVQAQQPGS
LRA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=243, Percent_Identity=35.3909465020576, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=37.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=49.7797356828194, Blast_Score=223, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=34.3478260869565, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=35.8490566037736, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=33.9366515837104, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18857969, Length=210, Percent_Identity=38.0952380952381, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26814; Mature: 26682

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVQGAIPHHIAIVMDGNGRWATRRFLPRLAGHRQGVESLRRCVHACVQRGVGVLTVFA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FSSENWNRPADEVSGLMDLLAKALTREVPQLARDGVQVHFVGEKSGISAQVREGLQRAEA
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHH
ATASNQRLVLNVCFNYGGRWDITQAAAALAARGEPITEASLHAAMGMAHVPDPDLLIRTG
HHCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEECC
GERRISNFLLWQAAYTELYFSDRLWPDFDEAALDEAIADFAARERRFGQTSDQVQAQQPG
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
SLRA
CCCC
>Mature Secondary Structure 
PTVQGAIPHHIAIVMDGNGRWATRRFLPRLAGHRQGVESLRRCVHACVQRGVGVLTVFA
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FSSENWNRPADEVSGLMDLLAKALTREVPQLARDGVQVHFVGEKSGISAQVREGLQRAEA
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHH
ATASNQRLVLNVCFNYGGRWDITQAAAALAARGEPITEASLHAAMGMAHVPDPDLLIRTG
HHCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEECC
GERRISNFLLWQAAYTELYFSDRLWPDFDEAALDEAIADFAARERRFGQTSDQVQAQQPG
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCC
SLRA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]