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The map label for this gene is pyrH [H]

Identifier: 222110428

GI number: 222110428

Start: 1287512

End: 1288234

Strand: Direct

Name: pyrH [H]

Synonym: Dtpsy_1225

Alternate gene names: 222110428

Gene position: 1287512-1288234 (Clockwise)

Preceding gene: 222110427

Following gene: 222110429

Centisome position: 33.91

GC content: 66.67

Gene sequence:

>723_bases
ATGACCCTCGCCACGCCAGCCCACAAGCGCATCCTGCTCAAGTTGTCTGGTGAGGCGCTCATGGGCGATGACGCATTCGG
CATCAACCGTGCCACGATCGTGCGCATGGTCGAGGAGATCGCCGAGGTCACCCGCCTGGGCGTGCAAGTGGCGGTGGTGA
TCGGCGGGGGCAACATCTTCCGCGGTGTGGCGGGCGGGTCCGTGGGCATGGACCGCGCCACGGCCGACTACATGGGCATG
CTGGCCACCGTGATGAACGCGCTGGCCCTGGCGGACGCCATGGACAAGCAGGGGCTGACGGCCCGCGTGATGTCCGCCAT
AGGCATCGAGCAGGTGGTGGAGCCCTACGTGCGTCCCAAGGCGCTGCAGTACCTCGAAGAGGGCAAAGTGGTGGTGTTCG
CCGCCGGAACCGGCAACCCCTTCTTCACCACCGACACGGCCGCCGCGCTGCGCGGCGCCGAGATCGGCGCCGAGGTGGTG
CTTAAGGCGACCAAGGTCGACGGCGTGTACACGGCCGATCCGATGAAGGACCCGTCGGCCACGCGCTATGCCAAGCTCAC
GTTCGACGAGGCCATGAGCCGCAACCTGGGCATCCTGGACGCGACGGCCTTTGCCCTGTGCCGCGACCAGAAGCTGCCGA
TCCGCGTGTTCTCCATCGTGAAACATGGCGCGCTGAAGCGCGTGGTGATGGGCGAAGACGAAGGCACGTTGGTGTACGCT
TGA

Upstream 100 bases:

>100_bases
CGAGGTGGCTGCGCAAGTCGCTGCCGCCAAGTCGGGCGCCTGATAGCGTCTGCCGCCCACGCCCTTCATCCCCCCAGTCC
AGCCTTACGGAGAATTGCCC

Downstream 100 bases:

>100_bases
TGGCTTTGCCGCGCCTGGCCTGATTGCCCGCTTGCAGAGGAACCACACATGACGATTGCCGACATCAAGAAGACGACCGA
GGCGAAGATGGACCAGTCCA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTLATPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRLGVQVAVVIGGGNIFRGVAGGSVGMDRATADYMGM
LATVMNALALADAMDKQGLTARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVV
LKATKVDGVYTADPMKDPSATRYAKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA

Sequences:

>Translated_240_residues
MTLATPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRLGVQVAVVIGGGNIFRGVAGGSVGMDRATADYMGM
LATVMNALALADAMDKQGLTARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVV
LKATKVDGVYTADPMKDPSATRYAKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA
>Mature_239_residues
TLATPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRLGVQVAVVIGGGNIFRGVAGGSVGMDRATADYMGML
ATVMNALALADAMDKQGLTARVMSAIGIEQVVEPYVRPKALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVVL
KATKVDGVYTADPMKDPSATRYAKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=237, Percent_Identity=58.2278481012658, Blast_Score=281, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25442; Mature: 25311

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLATPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRLGVQVAVVIGGGNIF
CCCCCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEE
RGVAGGSVGMDRATADYMGMLATVMNALALADAMDKQGLTARVMSAIGIEQVVEPYVRPK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCHH
ALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVVLKATKVDGVYTADPMKDPSA
HHHHHHCCCEEEEEECCCCCCEECCHHHHHHHHHCCHHHEEEEEECCCEEECCCCCCCCC
TRYAKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA
CEEEEEEHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEC
>Mature Secondary Structure 
TLATPAHKRILLKLSGEALMGDDAFGINRATIVRMVEEIAEVTRLGVQVAVVIGGGNIF
CCCCCCCCEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEE
RGVAGGSVGMDRATADYMGMLATVMNALALADAMDKQGLTARVMSAIGIEQVVEPYVRPK
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCHH
ALQYLEEGKVVVFAAGTGNPFFTTDTAAALRGAEIGAEVVLKATKVDGVYTADPMKDPSA
HHHHHHCCCEEEEEECCCCCCEECCHHHHHHHHHCCHHHEEEEEECCCEEECCCCCCCCC
TRYAKLTFDEAMSRNLGILDATAFALCRDQKLPIRVFSIVKHGALKRVVMGEDEGTLVYA
CEEEEEEHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA