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The map label for this gene is clpP [H]

Identifier: 222110341

GI number: 222110341

Start: 1185186

End: 1185794

Strand: Direct

Name: clpP [H]

Synonym: Dtpsy_1128

Alternate gene names: 222110341

Gene position: 1185186-1185794 (Clockwise)

Preceding gene: 222110340

Following gene: 222110342

Centisome position: 31.22

GC content: 60.59

Gene sequence:

>609_bases
ATGAGCGCATTGGAAACGCAAGCCCTGGGCATGATCCCCATGGTCATTGAGCAGTCCGGCCGCGGCGAGCGGTCCTACGA
CATTTATTCGCGCCTGTTGAAGGAGCGCGTGATCTTCCTGGTGGGTGAGGTCAATGACCAGACCGCCAACCTGGTGGTTG
CGCAGCTGCTGTTCCTTGAGAGCGAGAACCCGGACAAGGATATTTCGTTCTACATCAACTCCCCGGGGGGGAGCGTGACG
GCGGGCATGGCCATCTATGACACCATGCAGTTCATCAAGCCGGATGTGTCCACGCTGTGCTGCGGCTTTGCGGCGAGCAT
GGGGGCTTTCCTGCTGGCTGCAGGCGCCAAGGGCAAGCGCTATTCGCTGCCCAACTCCAAGATCATGATCCACCAGGTGC
TGGGCGGCGCCCGCGGACAGGCGACGGATATCGAGATCCACGCCCGCGACATTTTGCGTACCAAAGATCAGATGAACCGC
ATCCTGGCGGAGCGCACGGGACAGCCCATTGAGAAGGTGAAGGCGGATACCGAGCGGGACTATTTCATGACCGCGGACGA
AGCCAAGGATTACGGCATCGTGGACCAGGTCATCGCCAAGCGCCCCTGA

Upstream 100 bases:

>100_bases
TTTGACCCAGGGGTGAGGACGAAACCCGGCGGGGCTTGTGCTTTGCGGCACAAGCCCCAATTCATTTCTGGGTACAGTAT
CCGCCTGACTGGAGAAACGT

Downstream 100 bases:

>100_bases
GTTTGGGCCGGCGCGCGCGGCGTTTCCCCCTGTGGGAAACGCCGTTTTTATTTCGTTATCATCTTGACAACATCCCCAGT
CATAAGGCATTGCCCCCATG

Product: ATP-dependent clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSALETQALGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGEVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVT
AGMAIYDTMQFIKPDVSTLCCGFAASMGAFLLAAGAKGKRYSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNR
ILAERTGQPIEKVKADTERDYFMTADEAKDYGIVDQVIAKRP

Sequences:

>Translated_202_residues
MSALETQALGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGEVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVT
AGMAIYDTMQFIKPDVSTLCCGFAASMGAFLLAAGAKGKRYSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNR
ILAERTGQPIEKVKADTERDYFMTADEAKDYGIVDQVIAKRP
>Mature_201_residues
SALETQALGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGEVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVTA
GMAIYDTMQFIKPDVSTLCCGFAASMGAFLLAAGAKGKRYSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNRI
LAERTGQPIEKVKADTERDYFMTADEAKDYGIVDQVIAKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=202, Percent_Identity=55.9405940594059, Blast_Score=242, Evalue=1e-64,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=68.9119170984456, Blast_Score=293, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=58.7628865979381, Blast_Score=246, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22257; Mature: 22126

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALETQALGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGEVNDQTANLVVAQLLFLE
CCCCHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHC
SENPDKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCCGFAASMGAFLLAAGAKGKR
CCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCE
YSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNRILAERTGQPIEKVKADTERD
EECCCCCEEHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
YFMTADEAKDYGIVDQVIAKRP
EEEECCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SALETQALGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGEVNDQTANLVVAQLLFLE
CCCHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHC
SENPDKDISFYINSPGGSVTAGMAIYDTMQFIKPDVSTLCCGFAASMGAFLLAAGAKGKR
CCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCE
YSLPNSKIMIHQVLGGARGQATDIEIHARDILRTKDQMNRILAERTGQPIEKVKADTERD
EECCCCCEEHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCC
YFMTADEAKDYGIVDQVIAKRP
EEEECCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA