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The map label for this gene is guaD [H]

Identifier: 222110262

GI number: 222110262

Start: 1090611

End: 1091894

Strand: Direct

Name: guaD [H]

Synonym: Dtpsy_1049

Alternate gene names: 222110262

Gene position: 1090611-1091894 (Clockwise)

Preceding gene: 222110261

Following gene: 222110263

Centisome position: 28.73

GC content: 69.16

Gene sequence:

>1284_bases
ATGCACCTTTACCGATCTGCGCTCCTGCGCTTTGCCGATGACGGCACGGCCCTGTACGAAGAAGACGGCCTGTTGGCCAC
CGCGCCCGATGACCAGGGCGTGCAGCGCGTGCACGCCGCCGGCGCGTGGCGCGCGCTGGCGCCCCTCTATCTTCCTCAGG
CCTCGCAGCCGGTGACCCACTGGCCCGGCCGCATCATTGCACCGGGCTTCGTGGACATGCATGTGCACTACCCGCAGCTA
GACGTGATCGGCTCGCCCGCCGAAGGCCTGCTGCCCTGGCTGGAGAACTACACCTTCCCGCACGAGTCGCGATTCGCCGA
TGCCGGCTACGCCGCGGGGGTGGCGGGCTTTTTCCTGGATGAGCTGCAGCGCAACGGCGTGACCACGGCGCTCACCTTCG
CCACCTCGCATCCGGGCTCGGTGGATGCGCTGATGGCGCAGGCACAGGCGCGGCGGCTGCGCCTGATTGCCGGCAAGGTG
CTGCAAGACCGCCACTCGCCCGACGGCGTGCGCGACGCGACCGAGCAATCCCTCATCGACACCGAAGCGCTCATCCAGCG
CTGGCACGGCAAGGGGCGGCTGGGCTATGCGATCACGCCGCGTTTTGCCCCCACCAGCACGCCGCAGCAGCTGAGCGGCG
CGGGTGCTCTGGCCGCGCGCTACCCCGACGTATGGGTGCAGTCCCATGTGGCGGAGAACCAGCAGGAGATCCGCTGGGCG
CAGGAGCTGTTCCCCGGCACGCGGAGCTACCTGGATGTGTATGCCCGTGTCGGCCTGCTGCGTGTGCGCGCGGTGTACGC
GCATTGCATCCATTTCGACGACGAGGACCGCGCCGCCATGCGCGAGAGCGGCGCGGTGGCTGCCGTGTGCCCCACGAGCA
ACCTGTTCCTGGGCAGTGGCCAGTTTGACTTTGCGGGCGCGGACCGCATGGGCTTCGGCTACGGCTTGGCCAGCGACGTG
GGCGGCGGCACCAGCTTCAGCCCTTTCCACACGATGCTGGCCGCGTACTACGTAGGCCGGGAGGGGCAGACCAAGACGGG
ACTGAGCCTGGCGCCGCAACGGCTGTGGTGGCTGCATACCGCCGGCGCCGCGCGGGCGTTGGGGTTGGATGGCGTGGTGG
GCAACCTGCAGCCGGGTTGCGAAGCCGACTTCGTGGTACTGAATCCTGCGGCGACCCCGCTGCTGGCGCGGCGCACGGCG
GGCGCCGCCCACCTGGACGAACTGCTGTTCGCGATGATCGTGCTCGGCGACGACCGTTTGATCGAGCGCACTGTCATTGC
ATGA

Upstream 100 bases:

>100_bases
ACTGTCCGACGAAGAGCGCGAAACCTTCAAACGCTGGTACGAAAACGGCGCCAGCATCGCGCCCTGACGCCCCCCGGTAT
TGCGGGCATCATCCGGGGCC

Downstream 100 bases:

>100_bases
AATATTTGCCTCTGACGCTTATGTATCAAGCGTCAGCAGCTATCATTTAAGTAGCTTTCATTCGCCTAGAATACGCGCCA
GGAGTACCCCATGAGCATCA

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MHLYRSALLRFADDGTALYEEDGLLATAPDDQGVQRVHAAGAWRALAPLYLPQASQPVTHWPGRIIAPGFVDMHVHYPQL
DVIGSPAEGLLPWLENYTFPHESRFADAGYAAGVAGFFLDELQRNGVTTALTFATSHPGSVDALMAQAQARRLRLIAGKV
LQDRHSPDGVRDATEQSLIDTEALIQRWHGKGRLGYAITPRFAPTSTPQQLSGAGALAARYPDVWVQSHVAENQQEIRWA
QELFPGTRSYLDVYARVGLLRVRAVYAHCIHFDDEDRAAMRESGAVAAVCPTSNLFLGSGQFDFAGADRMGFGYGLASDV
GGGTSFSPFHTMLAAYYVGREGQTKTGLSLAPQRLWWLHTAGAARALGLDGVVGNLQPGCEADFVVLNPAATPLLARRTA
GAAHLDELLFAMIVLGDDRLIERTVIA

Sequences:

>Translated_427_residues
MHLYRSALLRFADDGTALYEEDGLLATAPDDQGVQRVHAAGAWRALAPLYLPQASQPVTHWPGRIIAPGFVDMHVHYPQL
DVIGSPAEGLLPWLENYTFPHESRFADAGYAAGVAGFFLDELQRNGVTTALTFATSHPGSVDALMAQAQARRLRLIAGKV
LQDRHSPDGVRDATEQSLIDTEALIQRWHGKGRLGYAITPRFAPTSTPQQLSGAGALAARYPDVWVQSHVAENQQEIRWA
QELFPGTRSYLDVYARVGLLRVRAVYAHCIHFDDEDRAAMRESGAVAAVCPTSNLFLGSGQFDFAGADRMGFGYGLASDV
GGGTSFSPFHTMLAAYYVGREGQTKTGLSLAPQRLWWLHTAGAARALGLDGVVGNLQPGCEADFVVLNPAATPLLARRTA
GAAHLDELLFAMIVLGDDRLIERTVIA
>Mature_427_residues
MHLYRSALLRFADDGTALYEEDGLLATAPDDQGVQRVHAAGAWRALAPLYLPQASQPVTHWPGRIIAPGFVDMHVHYPQL
DVIGSPAEGLLPWLENYTFPHESRFADAGYAAGVAGFFLDELQRNGVTTALTFATSHPGSVDALMAQAQARRLRLIAGKV
LQDRHSPDGVRDATEQSLIDTEALIQRWHGKGRLGYAITPRFAPTSTPQQLSGAGALAARYPDVWVQSHVAENQQEIRWA
QELFPGTRSYLDVYARVGLLRVRAVYAHCIHFDDEDRAAMRESGAVAAVCPTSNLFLGSGQFDFAGADRMGFGYGLASDV
GGGTSFSPFHTMLAAYYVGREGQTKTGLSLAPQRLWWLHTAGAARALGLDGVVGNLQPGCEADFVVLNPAATPLLARRTA
GAAHLDELLFAMIVLGDDRLIERTVIA

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=436, Percent_Identity=30.7339449541284, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789249, Length=406, Percent_Identity=44.5812807881773, Blast_Score=355, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6319963, Length=332, Percent_Identity=31.0240963855422, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24643849, Length=383, Percent_Identity=32.8981723237598, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 46213; Mature: 46213

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLYRSALLRFADDGTALYEEDGLLATAPDDQGVQRVHAAGAWRALAPLYLPQASQPVTH
CCHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
WPGRIIAPGFVDMHVHYPQLDVIGSPAEGLLPWLENYTFPHESRFADAGYAAGVAGFFLD
CCCCEECCCEEEEEEECCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ELQRNGVTTALTFATSHPGSVDALMAQAQARRLRLIAGKVLQDRHSPDGVRDATEQSLID
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TEALIQRWHGKGRLGYAITPRFAPTSTPQQLSGAGALAARYPDVWVQSHVAENQQEIRWA
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCCCCHHHCCCHHHHHHHHHCCHHHHHHH
QELFPGTRSYLDVYARVGLLRVRAVYAHCIHFDDEDRAAMRESGAVAAVCPTSNLFLGSG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCEEEECC
QFDFAGADRMGFGYGLASDVGGGTSFSPFHTMLAAYYVGREGQTKTGLSLAPQRLWWLHT
CCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEEC
AGAARALGLDGVVGNLQPGCEADFVVLNPAATPLLARRTAGAAHLDELLFAMIVLGDDRL
CCCHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHH
IERTVIA
HHHHHCC
>Mature Secondary Structure
MHLYRSALLRFADDGTALYEEDGLLATAPDDQGVQRVHAAGAWRALAPLYLPQASQPVTH
CCHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
WPGRIIAPGFVDMHVHYPQLDVIGSPAEGLLPWLENYTFPHESRFADAGYAAGVAGFFLD
CCCCEECCCEEEEEEECCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ELQRNGVTTALTFATSHPGSVDALMAQAQARRLRLIAGKVLQDRHSPDGVRDATEQSLID
HHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TEALIQRWHGKGRLGYAITPRFAPTSTPQQLSGAGALAARYPDVWVQSHVAENQQEIRWA
HHHHHHHHCCCCCEEEEECCCCCCCCCHHHHCCCCCHHHCCCHHHHHHHHHCCHHHHHHH
QELFPGTRSYLDVYARVGLLRVRAVYAHCIHFDDEDRAAMRESGAVAAVCPTSNLFLGSG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCEEEECC
QFDFAGADRMGFGYGLASDVGGGTSFSPFHTMLAAYYVGREGQTKTGLSLAPQRLWWLHT
CCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEEC
AGAARALGLDGVVGNLQPGCEADFVVLNPAATPLLARRTAGAAHLDELLFAMIVLGDDRL
CCCHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHH
IERTVIA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]