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The map label for this gene is ttuC [H]

Identifier: 222110253

GI number: 222110253

Start: 1081013

End: 1082110

Strand: Direct

Name: ttuC [H]

Synonym: Dtpsy_1040

Alternate gene names: 222110253

Gene position: 1081013-1082110 (Clockwise)

Preceding gene: 222110244

Following gene: 222110254

Centisome position: 28.47

GC content: 67.85

Gene sequence:

>1098_bases
ATGAGCAAGACCTATCGCATTGCCTGCATCCCCGGCGACGGCATCGGCAAGGAGGTAATCCCCGCCGGCCAGGCCGTGCT
GGAGGCATTAGCGGCATCCCAGCCGGGCCTGGGCTTTGCGTTCACCAGCTATGGCTGGGGCGGAGACTGGCATCGCGCGC
ACGGCGAGATGATGCCGGCCGACGGCCTGCAGGCGCTCAGGGACAAGGACGCCATCCTGTTCGGCTCGGCCGGCGACCCG
CATATCCCCGATCACATCACGCTGTGGGGCTTACGCCTGAAGATCTGCCAGGGGTTCGACCAGTACGCCAACGTGCGCCC
CACGCGCATCCTGCCGGGCATCGATGCGCCGCTCAAGCGTTGCGCGCCCCAGGACCTGGACTGGGTCATCGTGCGTGAAA
ACTCCGAAGGCGAATACGCCGGCGTGGGCGGCCGTGTGCACCAGGGCCATCCGCTGGAGGCCGCGACCGACGTGAGCATG
ATGACCCGCGCCGGTGTGGAGCGCATCATGCGCTTTGCGTTCAAACTGGCGCAGTCGCGTCCGCGTAAGCTGCTCACGGT
GGTCACCAAGAGCAACGCCCAGCGCCACGCCATGGTGATGTGGGACGAAATCGCGGTGCAGATCAGCCGCGAATTTCCCG
ATGTGCGGTGGGACAAGGAACTGGTGGACGCGGCGACCGCGCGCATGGTGAACCGCCCCGCATCGCTGGACACCATCGTC
GCCACCAACCTGCATGCCGACATCCTGAGCGACCTGGCCGCCGCGCTGGCGGGCAGCCTGGGGATAGCGCCCACCGGCAA
CATCGATCCCGAGCGCCGCTACCCCAGTATGTTTGAGCCCATCCACGGCTCGGCCTTCGACATCATGGGCAAGGGCCTGG
CCAACCCGGTGGGCACGTTCTGGAGCTGCGTGATGCTGCTGGAGCACCTGGGCGAACACGCCGCCGCGCAGCGCCTGATG
CGTGCCGTGGAGCATGTCACCGCCAACCCTGCGCTGCACACGGGCGACCTGGGCGGCCAGGCCACCACGCAGCAGGTCAC
CGATGCGGTGTGCGCCCAACTGGCGCAGCCGGTGGGACAGCAGGCAGCGCTGGCCTGA

Upstream 100 bases:

>100_bases
GCATCACTTTAACGCGGTGATATGTGGGCATGGCATCGCTAGATTCAGGGCCATGCCACGCATGTTGCGCGGCCTTCTGA
TTTGAGGAGCGAGCATTTCC

Downstream 100 bases:

>100_bases
GCCGGTGGGCGGCACGCACCGCCCATGCGTTTTCATCACGACAACACAGGAGACAAGAGATGAGGAACCTTCGCAAACGC
GCCCTGCTGGGTGCTTTGGC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSKTYRIACIPGDGIGKEVIPAGQAVLEALAASQPGLGFAFTSYGWGGDWHRAHGEMMPADGLQALRDKDAILFGSAGDP
HIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRCAPQDLDWVIVRENSEGEYAGVGGRVHQGHPLEAATDVSM
MTRAGVERIMRFAFKLAQSRPRKLLTVVTKSNAQRHAMVMWDEIAVQISREFPDVRWDKELVDAATARMVNRPASLDTIV
ATNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSCVMLLEHLGEHAAAQRLM
RAVEHVTANPALHTGDLGGQATTQQVTDAVCAQLAQPVGQQAALA

Sequences:

>Translated_365_residues
MSKTYRIACIPGDGIGKEVIPAGQAVLEALAASQPGLGFAFTSYGWGGDWHRAHGEMMPADGLQALRDKDAILFGSAGDP
HIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRCAPQDLDWVIVRENSEGEYAGVGGRVHQGHPLEAATDVSM
MTRAGVERIMRFAFKLAQSRPRKLLTVVTKSNAQRHAMVMWDEIAVQISREFPDVRWDKELVDAATARMVNRPASLDTIV
ATNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSCVMLLEHLGEHAAAQRLM
RAVEHVTANPALHTGDLGGQATTQQVTDAVCAQLAQPVGQQAALA
>Mature_364_residues
SKTYRIACIPGDGIGKEVIPAGQAVLEALAASQPGLGFAFTSYGWGGDWHRAHGEMMPADGLQALRDKDAILFGSAGDPH
IPDHITLWGLRLKICQGFDQYANVRPTRILPGIDAPLKRCAPQDLDWVIVRENSEGEYAGVGGRVHQGHPLEAATDVSMM
TRAGVERIMRFAFKLAQSRPRKLLTVVTKSNAQRHAMVMWDEIAVQISREFPDVRWDKELVDAATARMVNRPASLDTIVA
TNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTFWSCVMLLEHLGEHAAAQRLMR
AVEHVTANPALHTGDLGGQATTQQVTDAVCAQLAQPVGQQAALA

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=349, Percent_Identity=31.5186246418338, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI4758582, Length=343, Percent_Identity=28.8629737609329, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI28178816, Length=356, Percent_Identity=26.4044943820225, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI28178838, Length=321, Percent_Identity=28.0373831775701, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI28178821, Length=353, Percent_Identity=25.2124645892351, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI28178819, Length=198, Percent_Identity=26.7676767676768, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788101, Length=358, Percent_Identity=48.8826815642458, Blast_Score=344, Evalue=6e-96,
Organism=Escherichia coli, GI87081683, Length=370, Percent_Identity=34.0540540540541, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787381, Length=361, Percent_Identity=27.1468144044321, Blast_Score=104, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=349, Percent_Identity=32.378223495702, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17550882, Length=356, Percent_Identity=27.8089887640449, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144293, Length=350, Percent_Identity=27.7142857142857, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17505779, Length=350, Percent_Identity=25.4285714285714, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=36.1643835616438, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324709, Length=362, Percent_Identity=33.1491712707182, Blast_Score=175, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6324291, Length=356, Percent_Identity=29.7752808988764, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319830, Length=373, Percent_Identity=30.2949061662198, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24643270, Length=361, Percent_Identity=31.3019390581717, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24643268, Length=361, Percent_Identity=31.3019390581717, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24661184, Length=358, Percent_Identity=30.4469273743017, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI281362242, Length=361, Percent_Identity=29.3628808864266, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24648872, Length=361, Percent_Identity=29.3628808864266, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161078639, Length=258, Percent_Identity=27.906976744186, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078633, Length=258, Percent_Identity=27.906976744186, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24650122, Length=258, Percent_Identity=27.906976744186, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078635, Length=258, Percent_Identity=27.906976744186, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI161078637, Length=258, Percent_Identity=27.906976744186, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI20130355, Length=354, Percent_Identity=24.8587570621469, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45550436, Length=264, Percent_Identity=22.7272727272727, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39342; Mature: 39211

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTYRIACIPGDGIGKEVIPAGQAVLEALAASQPGLGFAFTSYGWGGDWHRAHGEMMPA
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHCCCCCCH
DGLQALRDKDAILFGSAGDPHIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDAPLKR
HHHHHHHCCCCEEECCCCCCCCCCCEEHHHHHHHHHHCHHHHHCCCCCEECCCCCHHHHH
CAPQDLDWVIVRENSEGEYAGVGGRVHQGHPLEAATDVSMMTRAGVERIMRFAFKLAQSR
CCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRKLLTVVTKSNAQRHAMVMWDEIAVQISREFPDVRWDKELVDAATARMVNRPASLDTIV
CHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
ATNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHCCCCCCHHHHHHCCCCCHHHHH
WSCVMLLEHLGEHAAAQRLMRAVEHVTANPALHTGDLGGQATTQQVTDAVCAQLAQPVGQ
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCH
QAALA
HHCCC
>Mature Secondary Structure 
SKTYRIACIPGDGIGKEVIPAGQAVLEALAASQPGLGFAFTSYGWGGDWHRAHGEMMPA
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHCCCCCCH
DGLQALRDKDAILFGSAGDPHIPDHITLWGLRLKICQGFDQYANVRPTRILPGIDAPLKR
HHHHHHHCCCCEEECCCCCCCCCCCEEHHHHHHHHHHCHHHHHCCCCCEECCCCCHHHHH
CAPQDLDWVIVRENSEGEYAGVGGRVHQGHPLEAATDVSMMTRAGVERIMRFAFKLAQSR
CCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRKLLTVVTKSNAQRHAMVMWDEIAVQISREFPDVRWDKELVDAATARMVNRPASLDTIV
CHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
ATNLHADILSDLAAALAGSLGIAPTGNIDPERRYPSMFEPIHGSAFDIMGKGLANPVGTF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHCCCCCCHHHHHHCCCCCHHHHH
WSCVMLLEHLGEHAAAQRLMRAVEHVTANPALHTGDLGGQATTQQVTDAVCAQLAQPVGQ
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCH
QAALA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]