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The map label for this gene is dxs

Identifier: 222110170

GI number: 222110170

Start: 985525

End: 987414

Strand: Direct

Name: dxs

Synonym: Dtpsy_0956

Alternate gene names: 222110170

Gene position: 985525-987414 (Clockwise)

Preceding gene: 222110169

Following gene: 222110171

Centisome position: 25.96

GC content: 68.99

Gene sequence:

>1890_bases
ATGTCCACGACGAACTATCCGCTGCTTGAGCGCGTGAACGATCCCGCCGACCTGCGCCGGCTGCCCCGTGCCGAGCTCAA
GGCGCTGGCTACGGAGCTGCGCGCCTTCGTGCTGGAGAGCGTGTCCAAGACCGGCGGGCATCTGTCGTCCAACCTGGGCA
CGGTGGAGCTGACCGTGGCGCTGCACGCCGTGTTCGACACGCCGCGCGACCGGCTGGTGTGGGACGTGGGCCACCAGACT
TACCCGCACAAAATCCTGACCGGGCGGCGCGACCGCATGCCCTCGCTGCGCCAGCTGGGCGGCCTGTCGGGCTTTCCGCA
GCGCGCCGAGAGCGAATACGACACCTTTGGCACCGCGCACTCGTCCACCAGCATCTCCGCGGCGCTGGGCATGGCGCTGG
CGGCCAAGCAGCGCGGCGACGAACGCCGCTGTGTAGCCATCATCGGCGACGGCGCCATGACCGCCGGCATGGCCTTCGAG
GCGCTGAATAACGCCGGCGTGGCCGACGCCAACCTGCTGGTCATCCTGAACGACAACGACATGAGCATCAGCCCGCCCGT
GGGTGCACTGAACCGCTACCTGGCGCAGCTCATGAGCGGACAGTTCTACGCCAAGGCACGCGACGTGGGCAAGAGCGTGC
TCAAGAACGCGCCACCGCTGCTGGAGCTGGCCAAGCGCCTGGAGCAGCAAGCCAAGGGCATGGTGGTGCCGGCCACCCTG
TTCGAGAAGTTCGGCTTCAACTACATCGGCCCCATTGATGGGCACGACCTGGACTCGCTGATTCCTACGCTGGAAAACAT
CCGCGGTCTCAAGGGCCCGCAGTTCCTGCACGTAGTCACCAAGAAGGGCCAGGGCTACAAGCTGGCCGAGGCCGACCCGG
TGGCCTACCACGGCCCGGGCAAGTTCGACCCGCGTGTGGGCCTGGTGAAACCGGCCACGCCGCCCAAGCAGACCTTCACG
CAGGTCTTTGGCCAGTGGCTGTGCGACATGGCCGAGAAGGACGAGCGCCTGGTGGGCATCACGCCCGCCATGCGCGAGGG
GTCGGGCATGGTGGAGTTCCACCAGCGCTTTCCCGAGCGCTACTACGACGTGGGCATCGCCGAGCAGCACGCCGTGACCT
TTGCCGCCGGTATGGCGTGCGAGGGGGCGAAGCCGGTGGTTGCGATCTACTCGACCTTCCTGCAGCGCGCCTATGACCAG
CTTATCCACGACGTGGCGCTGCAGAACCTGCCCGTGGTGTTTGCCCTGGACCGTGCGGGCCTGGTGGGTGCGGACGGCGC
CACGCACGCCGGAGCGTATGACATCGCCTTCGTGCGCTGCATTCCCAACATGAGCATGGCCTGCCCGGCCGACGAGCGCG
AATGCCGCCAACTGCTCACCACCGCCTACGAGCAAGACCACCCTGTGGCCGTGCGCTACCCGCGCGGCGCGGGCGTGGGC
GTGGCGCCGCTGCCCGATCTGGAGGGGCTGCCCTTCGGCAAGGGCGAGGTGCGCCGCAAGGGCCGGCGCATGGCCATCCT
GGCTTTCGGCACGCTGCTGTACCCGGCGCTGCAGGCGGCCGAGGCGCTGGACGCCACGGTGGTCAACATGCGCTGGGCCA
AGCCGCTGGATACGCAGCTGCTGCTTCAGGTGGCAGCGGAGCACGATGCGCTGGTCACCGTCGAGGAGGGCTGCATCATG
GGCGGCGCCGGCAGTGCCGTGGCCGAGGCGCTGGCCGCCGCAGGCGTGCAGCGCCCCTTGCTGCAACTGGGCCTGCCCGA
CGCGTTCATCGAGCATGGCGACCCGGCCAAGCTGCTGGCCCTGCAGGGGCTGGACGCCGCTGGCATGCAGCGCTCCATCA
CCGAGCGCTTCGGCGCATTGCCGGGCGAGCAGGCGCTGGCAGCGGCCTGA

Upstream 100 bases:

>100_bases
TGGGCAAGGCTGCGCATGGCGGGGCTGGTGTCTTTTTATGAATCAAATTGGCCTCTAGCGCTTGTTCATCAAGCGCTAAC
AGCTACTAAAAACATAGCAT

Downstream 100 bases:

>100_bases
CGCGCTTTCCTTCCCTTCACAACAATGCAGTCACCCCGCGGCAGCGTGCCGCTGGGATGCGTCGCGGCGCCTGTGCAGCC
CATCGCGGAGGCCTGCGCTG

Product: 1-deoxy-d-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSTTNYPLLERVNDPADLRRLPRAELKALATELRAFVLESVSKTGGHLSSNLGTVELTVALHAVFDTPRDRLVWDVGHQT
YPHKILTGRRDRMPSLRQLGGLSGFPQRAESEYDTFGTAHSSTSISAALGMALAAKQRGDERRCVAIIGDGAMTAGMAFE
ALNNAGVADANLLVILNDNDMSISPPVGALNRYLAQLMSGQFYAKARDVGKSVLKNAPPLLELAKRLEQQAKGMVVPATL
FEKFGFNYIGPIDGHDLDSLIPTLENIRGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPRVGLVKPATPPKQTFT
QVFGQWLCDMAEKDERLVGITPAMREGSGMVEFHQRFPERYYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRAYDQ
LIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAFVRCIPNMSMACPADERECRQLLTTAYEQDHPVAVRYPRGAGVG
VAPLPDLEGLPFGKGEVRRKGRRMAILAFGTLLYPALQAAEALDATVVNMRWAKPLDTQLLLQVAAEHDALVTVEEGCIM
GGAGSAVAEALAAAGVQRPLLQLGLPDAFIEHGDPAKLLALQGLDAAGMQRSITERFGALPGEQALAAA

Sequences:

>Translated_629_residues
MSTTNYPLLERVNDPADLRRLPRAELKALATELRAFVLESVSKTGGHLSSNLGTVELTVALHAVFDTPRDRLVWDVGHQT
YPHKILTGRRDRMPSLRQLGGLSGFPQRAESEYDTFGTAHSSTSISAALGMALAAKQRGDERRCVAIIGDGAMTAGMAFE
ALNNAGVADANLLVILNDNDMSISPPVGALNRYLAQLMSGQFYAKARDVGKSVLKNAPPLLELAKRLEQQAKGMVVPATL
FEKFGFNYIGPIDGHDLDSLIPTLENIRGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPRVGLVKPATPPKQTFT
QVFGQWLCDMAEKDERLVGITPAMREGSGMVEFHQRFPERYYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRAYDQ
LIHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAFVRCIPNMSMACPADERECRQLLTTAYEQDHPVAVRYPRGAGVG
VAPLPDLEGLPFGKGEVRRKGRRMAILAFGTLLYPALQAAEALDATVVNMRWAKPLDTQLLLQVAAEHDALVTVEEGCIM
GGAGSAVAEALAAAGVQRPLLQLGLPDAFIEHGDPAKLLALQGLDAAGMQRSITERFGALPGEQALAAA
>Mature_628_residues
STTNYPLLERVNDPADLRRLPRAELKALATELRAFVLESVSKTGGHLSSNLGTVELTVALHAVFDTPRDRLVWDVGHQTY
PHKILTGRRDRMPSLRQLGGLSGFPQRAESEYDTFGTAHSSTSISAALGMALAAKQRGDERRCVAIIGDGAMTAGMAFEA
LNNAGVADANLLVILNDNDMSISPPVGALNRYLAQLMSGQFYAKARDVGKSVLKNAPPLLELAKRLEQQAKGMVVPATLF
EKFGFNYIGPIDGHDLDSLIPTLENIRGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPGKFDPRVGLVKPATPPKQTFTQ
VFGQWLCDMAEKDERLVGITPAMREGSGMVEFHQRFPERYYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRAYDQL
IHDVALQNLPVVFALDRAGLVGADGATHAGAYDIAFVRCIPNMSMACPADERECRQLLTTAYEQDHPVAVRYPRGAGVGV
APLPDLEGLPFGKGEVRRKGRRMAILAFGTLLYPALQAAEALDATVVNMRWAKPLDTQLLLQVAAEHDALVTVEEGCIMG
GAGSAVAEALAAAGVQRPLLQLGLPDAFIEHGDPAKLLALQGLDAAGMQRSITERFGALPGEQALAAA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=641, Percent_Identity=23.2449297971919, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4507521, Length=641, Percent_Identity=23.2449297971919, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI225637459, Length=421, Percent_Identity=25.41567695962, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI225637461, Length=421, Percent_Identity=25.41567695962, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637463, Length=421, Percent_Identity=25.41567695962, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI133778974, Length=425, Percent_Identity=22.8235294117647, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI156564403, Length=275, Percent_Identity=24.3636363636364, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786622, Length=610, Percent_Identity=59.8360655737705, Blast_Score=758, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=387, Percent_Identity=27.390180878553, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538422, Length=294, Percent_Identity=25.1700680272109, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666278, Length=660, Percent_Identity=24.8484848484848, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551847, Length=639, Percent_Identity=25.3521126760563, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45550715, Length=639, Percent_Identity=25.3521126760563, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=25.1356238698011, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358145, Length=228, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24650940, Length=228, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ACIET (B9MEU8)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552434.1
- GeneID:   7384459
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0956
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67573; Mature: 67442

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTNYPLLERVNDPADLRRLPRAELKALATELRAFVLESVSKTGGHLSSNLGTVELTVA
CCCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEE
LHAVFDTPRDRLVWDVGHQTYPHKILTGRRDRMPSLRQLGGLSGFPQRAESEYDTFGTAH
HHHHHCCCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCHHHCCHHHHCCCCC
SSTSISAALGMALAAKQRGDERRCVAIIGDGAMTAGMAFEALNNAGVADANLLVILNDND
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCCC
MSISPPVGALNRYLAQLMSGQFYAKARDVGKSVLKNAPPLLELAKRLEQQAKGMVVPATL
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHH
FEKFGFNYIGPIDGHDLDSLIPTLENIRGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPG
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCEEECCCC
KFDPRVGLVKPATPPKQTFTQVFGQWLCDMAEKDERLVGITPAMREGSGMVEFHQRFPER
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHHHHHHCCHH
YYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFALDRAG
HHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVGADGATHAGAYDIAFVRCIPNMSMACPADERECRQLLTTAYEQDHPVAVRYPRGAGVG
EECCCCCCCCCHHHEEHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
VAPLPDLEGLPFGKGEVRRKGRRMAILAFGTLLYPALQAAEALDATVVNMRWAKPLDTQL
CCCCCCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
LLQVAAEHDALVTVEEGCIMGGAGSAVAEALAAAGVQRPLLQLGLPDAFIEHGDPAKLLA
HHHHHHCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHEEE
LQGLDAAGMQRSITERFGALPGEQALAAA
ECCCCHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure 
STTNYPLLERVNDPADLRRLPRAELKALATELRAFVLESVSKTGGHLSSNLGTVELTVA
CCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEEEE
LHAVFDTPRDRLVWDVGHQTYPHKILTGRRDRMPSLRQLGGLSGFPQRAESEYDTFGTAH
HHHHHCCCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCHHHCCHHHHCCCCC
SSTSISAALGMALAAKQRGDERRCVAIIGDGAMTAGMAFEALNNAGVADANLLVILNDND
CCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCCC
MSISPPVGALNRYLAQLMSGQFYAKARDVGKSVLKNAPPLLELAKRLEQQAKGMVVPATL
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHH
FEKFGFNYIGPIDGHDLDSLIPTLENIRGLKGPQFLHVVTKKGQGYKLAEADPVAYHGPG
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECCCCCEEECCCC
KFDPRVGLVKPATPPKQTFTQVFGQWLCDMAEKDERLVGITPAMREGSGMVEFHQRFPER
CCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHHHHHHCCHH
YYDVGIAEQHAVTFAAGMACEGAKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFALDRAG
HHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVGADGATHAGAYDIAFVRCIPNMSMACPADERECRQLLTTAYEQDHPVAVRYPRGAGVG
EECCCCCCCCCHHHEEHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
VAPLPDLEGLPFGKGEVRRKGRRMAILAFGTLLYPALQAAEALDATVVNMRWAKPLDTQL
CCCCCCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
LLQVAAEHDALVTVEEGCIMGGAGSAVAEALAAAGVQRPLLQLGLPDAFIEHGDPAKLLA
HHHHHHCCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHEEE
LQGLDAAGMQRSITERFGALPGEQALAAA
ECCCCHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA