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The map label for this gene is ispA [C]

Identifier: 222110169

GI number: 222110169

Start: 984501

End: 985421

Strand: Direct

Name: ispA [C]

Synonym: Dtpsy_0955

Alternate gene names: 222110169

Gene position: 984501-985421 (Clockwise)

Preceding gene: 222110168

Following gene: 222110170

Centisome position: 25.93

GC content: 71.23

Gene sequence:

>921_bases
ATGGACGCAGGAGTGACGCCCGCCATGTCCGCCGTACCTGTGTTCGATTTCGATGGCTGGATGCGCGCGCAGCTTGCGCG
GGTCGAGGACGCCCTGTCCCACTGGGTGTGCCCCGATGCGCCCGCAGGCCTGGGCGAGGCCATGCGCTATGCCGTGCTGG
ATGGCGGCAAGCGCCTGCGCCCGCTGCTGGTGCTGGCCGCTTGCGAGGCCGTCGGTGGAAACGCGCAGGCCGCCCTGCGC
GCCGCCTGCGCGGTGGAGCTGATCCACGCCTATTCGCTGGTGCATGACGACATGCCCTGCATGGACAACGATGTGATGCG
CCGCGGCAAGCCCACGGTGCATGTGCCCTTTGGCGAAGCGCGTGCACTGCTGGCGGGCGACGCACTGCAGGCGCTGGCAT
TTGAGCTGCTCACGCCCGAGGATGGGGTACCGCCGGCCATGCAGGCGCGGCTGTGCCGTGAGCTGGCCCGCGCCGCAGGC
GCCGACGGCATGGCCGGCGGGCAGGCCATCGACCTGGCCAGCGTGGGCCTGCAGTTGTCTGAAGACCAGTTGCGTCAGAT
GCACCGCCTGAAGACGGGCGCGCTGCTGCAGGCCAGCGTGGTGATGGGCGCGGTCTGCGGCCAGACCCCGGAGGGCACGC
TGCGCGCGCTGAGCGACTACGGCGCAGCCATGGGGCTGGCCTTCCAGGTGGTGGACGACGTGCTGGACGTGACCCAGGAC
TCCGCCACACTGGGCAAGACCGCCGGCAAGGACGCCGCGTGCGACAAGCCGACCTATGTCTCGCTGATGGGGCTGGAGGC
CGCGCGCGCGCATGCCGAAGCCCTGCGCGCGCAGGCACTGGCGGCGTTGGCCGCCAGCGGCCTGACCGACACGCGGGCGT
TGGCGGCGTTGGCCGACATGGTGGTGCGCCGTTCGCATTGA

Upstream 100 bases:

>100_bases
CGGGCTACCAGCGGGGCGCGGTGTTGCTGAACTTCTGCCGCGCGCGCCTGGACGCGGTGCAGGACCAGATCAAGGTGCTG
GACGAAGGCACGCTGCAGCC

Downstream 100 bases:

>100_bases
TGATGGGCAAGGCTGCGCATGGCGGGGCTGGTGTCTTTTTATGAATCAAATTGGCCTCTAGCGCTTGTTCATCAAGCGCT
AACAGCTACTAAAAACATAG

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MDAGVTPAMSAVPVFDFDGWMRAQLARVEDALSHWVCPDAPAGLGEAMRYAVLDGGKRLRPLLVLAACEAVGGNAQAALR
AACAVELIHAYSLVHDDMPCMDNDVMRRGKPTVHVPFGEARALLAGDALQALAFELLTPEDGVPPAMQARLCRELARAAG
ADGMAGGQAIDLASVGLQLSEDQLRQMHRLKTGALLQASVVMGAVCGQTPEGTLRALSDYGAAMGLAFQVVDDVLDVTQD
SATLGKTAGKDAACDKPTYVSLMGLEAARAHAEALRAQALAALAASGLTDTRALAALADMVVRRSH

Sequences:

>Translated_306_residues
MDAGVTPAMSAVPVFDFDGWMRAQLARVEDALSHWVCPDAPAGLGEAMRYAVLDGGKRLRPLLVLAACEAVGGNAQAALR
AACAVELIHAYSLVHDDMPCMDNDVMRRGKPTVHVPFGEARALLAGDALQALAFELLTPEDGVPPAMQARLCRELARAAG
ADGMAGGQAIDLASVGLQLSEDQLRQMHRLKTGALLQASVVMGAVCGQTPEGTLRALSDYGAAMGLAFQVVDDVLDVTQD
SATLGKTAGKDAACDKPTYVSLMGLEAARAHAEALRAQALAALAASGLTDTRALAALADMVVRRSH
>Mature_306_residues
MDAGVTPAMSAVPVFDFDGWMRAQLARVEDALSHWVCPDAPAGLGEAMRYAVLDGGKRLRPLLVLAACEAVGGNAQAALR
AACAVELIHAYSLVHDDMPCMDNDVMRRGKPTVHVPFGEARALLAGDALQALAFELLTPEDGVPPAMQARLCRELARAAG
ADGMAGGQAIDLASVGLQLSEDQLRQMHRLKTGALLQASVVMGAVCGQTPEGTLRALSDYGAAMGLAFQVVDDVLDVTQD
SATLGKTAGKDAACDKPTYVSLMGLEAARAHAEALRAQALAALAASGLTDTRALAALADMVVRRSH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=222, Percent_Identity=32.4324324324324, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1786623, Length=301, Percent_Identity=46.5116279069767, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1789578, Length=211, Percent_Identity=34.5971563981043, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24651612, Length=268, Percent_Identity=27.2388059701493, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31824; Mature: 31824

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAGVTPAMSAVPVFDFDGWMRAQLARVEDALSHWVCPDAPAGLGEAMRYAVLDGGKRLR
CCCCCCCCHHCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHH
PLLVLAACEAVGGNAQAALRAACAVELIHAYSLVHDDMPCMDNDVMRRGKPTVHVPFGEA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEECCCHH
RALLAGDALQALAFELLTPEDGVPPAMQARLCRELARAAGADGMAGGQAIDLASVGLQLS
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCC
EDQLRQMHRLKTGALLQASVVMGAVCGQTPEGTLRALSDYGAAMGLAFQVVDDVLDVTQD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SATLGKTAGKDAACDKPTYVSLMGLEAARAHAEALRAQALAALAASGLTDTRALAALADM
CHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VVRRSH
HHHCCC
>Mature Secondary Structure
MDAGVTPAMSAVPVFDFDGWMRAQLARVEDALSHWVCPDAPAGLGEAMRYAVLDGGKRLR
CCCCCCCCHHCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHH
PLLVLAACEAVGGNAQAALRAACAVELIHAYSLVHDDMPCMDNDVMRRGKPTVHVPFGEA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEECCCHH
RALLAGDALQALAFELLTPEDGVPPAMQARLCRELARAAGADGMAGGQAIDLASVGLQLS
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCC
EDQLRQMHRLKTGALLQASVVMGAVCGQTPEGTLRALSDYGAAMGLAFQVVDDVLDVTQD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SATLGKTAGKDAACDKPTYVSLMGLEAARAHAEALRAQALAALAASGLTDTRALAALADM
CHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VVRRSH
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]