Click here to switch to the map view.

The map label for this gene is folE [H]

Identifier: 222110023

GI number: 222110023

Start: 840374

End: 841099

Strand: Direct

Name: folE [H]

Synonym: Dtpsy_0808

Alternate gene names: 222110023

Gene position: 840374-841099 (Clockwise)

Preceding gene: 222110022

Following gene: 222110024

Centisome position: 22.14

GC content: 65.43

Gene sequence:

>726_bases
ATGTCTTCAGAACCCCCAGCACCCCTGAGCGGCGCCGCGCCCGACGAGGGTACGCCCGTCTCCGTCAAGATTCGCGAACG
GCTGAACGCGGCGCGCCGGCGCTTCCATGCCAACGACAACATTGCGGAGTTCATCCAGCCCGGCGAGCTGGAGCGCCTGC
TGGACGAGGTCGAGGCCAAGATGCAGGGCGTCCTCGACAGCATGGTGATCGACACAGCGGGCGACCACAACACGCAGGCC
ACGGCGCGCCGGGTGGCCAAGATGTACCTCAACGAGGTCTTCAAGGGCCGCTACGTGCAGCCGCCGGCGATCACCGAGTT
TCCCAACGCCGAGCACCTGAACGAGCTGATGATCGTCGGCCCCGTCACCGTGCGCAGCGCCTGCAGCCACCACTTCTGCC
CGGTGATCGGCAAGATCTGGATCGGCGTGCTGCCCAACGAGCACACCAACGTGATCGGTCTGTCCAAGTACGCGCGCCTC
GTGGACTGGGTCATGGGGCGTCCCCAGATCCAGGAGGAGGCCGTGGTGCAGCTGGCCGACCTCATCATGGAAAAGACCCA
GCCCGACGGGCTGGCCATCGTCATGGAGGCCAGCCACTTCTGTATGTCCTGGCGCGGTGTGCGCGAGATGGACAGCAAGA
TGATCAACTCGGTGATGCGCGGGGTGTTCCTCACCAACCCCACGCTGCGCCGCGAATTCCTGGCCCTCATTCCCCGAAGG
AGCTGA

Upstream 100 bases:

>100_bases
ATTGCTATTGTTTGGATAGCTGCTGGCGCTTGCCCCATAAGCGCTAGAGGCATAAAAGGCTTATAAAGCCTGGATCGGCA
TTCGCTGGTACCATGCCGCC

Downstream 100 bases:

>100_bases
CCCATGCTGGTCCGTCTTCTCTACGTCAGCCGCGCCGTCGATACCTCGCCCGAGGCCATCGAGGCCATCCTCACCCAGTC
GCGCCAGCACAACCCCGCCA

Product: GTP cyclohydrolase i

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSSEPPAPLSGAAPDEGTPVSVKIRERLNAARRRFHANDNIAEFIQPGELERLLDEVEAKMQGVLDSMVIDTAGDHNTQA
TARRVAKMYLNEVFKGRYVQPPAITEFPNAEHLNELMIVGPVTVRSACSHHFCPVIGKIWIGVLPNEHTNVIGLSKYARL
VDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKMINSVMRGVFLTNPTLRREFLALIPRR
S

Sequences:

>Translated_241_residues
MSSEPPAPLSGAAPDEGTPVSVKIRERLNAARRRFHANDNIAEFIQPGELERLLDEVEAKMQGVLDSMVIDTAGDHNTQA
TARRVAKMYLNEVFKGRYVQPPAITEFPNAEHLNELMIVGPVTVRSACSHHFCPVIGKIWIGVLPNEHTNVIGLSKYARL
VDWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKMINSVMRGVFLTNPTLRREFLALIPRR
S
>Mature_240_residues
SSEPPAPLSGAAPDEGTPVSVKIRERLNAARRRFHANDNIAEFIQPGELERLLDEVEAKMQGVLDSMVIDTAGDHNTQAT
ARRVAKMYLNEVFKGRYVQPPAITEFPNAEHLNELMIVGPVTVRSACSHHFCPVIGKIWIGVLPNEHTNVIGLSKYARLV
DWVMGRPQIQEEAVVQLADLIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKMINSVMRGVFLTNPTLRREFLALIPRRS

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=127, Percent_Identity=45.6692913385827, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4503949, Length=127, Percent_Identity=45.6692913385827, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI66932970, Length=88, Percent_Identity=42.0454545454545, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI66932972, Length=88, Percent_Identity=42.0454545454545, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788476, Length=179, Percent_Identity=31.8435754189944, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=130, Percent_Identity=43.0769230769231, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321706, Length=187, Percent_Identity=35.2941176470588, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24656791, Length=127, Percent_Identity=40.9448818897638, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656782, Length=127, Percent_Identity=40.9448818897638, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656796, Length=127, Percent_Identity=40.9448818897638, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26982; Mature: 26850

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEPPAPLSGAAPDEGTPVSVKIRERLNAARRRFHANDNIAEFIQPGELERLLDEVEAK
CCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHH
MQGVLDSMVIDTAGDHNTQATARRVAKMYLNEVFKGRYVQPPAITEFPNAEHLNELMIVG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCEEEEC
PVTVRSACSHHFCPVIGKIWIGVLPNEHTNVIGLSKYARLVDWVMGRPQIQEEAVVQLAD
CHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKMINSVMRGVFLTNPTLRREFLALIPRR
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
S
C
>Mature Secondary Structure 
SSEPPAPLSGAAPDEGTPVSVKIRERLNAARRRFHANDNIAEFIQPGELERLLDEVEAK
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHH
MQGVLDSMVIDTAGDHNTQATARRVAKMYLNEVFKGRYVQPPAITEFPNAEHLNELMIVG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCEEEEC
PVTVRSACSHHFCPVIGKIWIGVLPNEHTNVIGLSKYARLVDWVMGRPQIQEEAVVQLAD
CHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LIMEKTQPDGLAIVMEASHFCMSWRGVREMDSKMINSVMRGVFLTNPTLRREFLALIPRR
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA