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The map label for this gene is galE [H]

Identifier: 222109952

GI number: 222109952

Start: 768845

End: 769864

Strand: Direct

Name: galE [H]

Synonym: Dtpsy_0737

Alternate gene names: 222109952

Gene position: 768845-769864 (Clockwise)

Preceding gene: 222109947

Following gene: 222109953

Centisome position: 20.25

GC content: 70.69

Gene sequence:

>1020_bases
ATGATTCTTGTAACCGGGGGCGCGGGCTTCATCGGCACCCACACCTGCGCGGCCCTTGCCGATGCAGGCATTCCCACCTT
GCTGCTCGACAACTTCAGCAACAGCCGCCGCAGCGTGCTGGACCGCCTGGCGCGCATCACCGGCAAGCCGGTGGCGTGCG
TCGAGGGCGACGTGCGCGACGCGCAGTTGCTGCGGCAACTGTTTGCGTCCCACCCCATCGAGGGCGTGATCCACTTCGCC
GCGCTCAAGGCCGTGGGCGAATCGGTGCGCGAGCCGCTGCGCTACTACGAAAACAACGTGGCGGGGACGGTGAGCCTGCT
GCGCGCCATGCAGGCGGCCGGCGTGCGCACGCTGGTGTTTTCCTCCTCGGCCACGGTGTATGGCGATCCGGCGAGCCTGC
CCATCCGCGAGGACTTCCCGCTGTCGGCCACCAACCCTTACGGCTGGAGCAAGCTGATGATGGAGCAGGTGCTGGCCGAT
GTGGACCACGCCGAGCCCGGCCAGTGGCGCATTGCGCGGCTGCGCTACTTCAACCCCGTGGGCGCGCACGAGAGCGGGCT
GATCGGCGAGGACCCGCAGGACATTCCCAACAACCTCATGCCCTACGTGGCCCAGGTGGCCACGGGCCAGCGCGAGGTGC
TGAGCGTGTACGGCGGCGACTACCCCACGCCCGACGGCACGGGCGTGCGCGACTACATCCACGTGTGCGATCTGGCCGAA
GGCCACGTGGCCGCGCTGCGCTACCTGCGCGCGCATCCGGGGCTGCTCACGGTGAACCTCGGCACGGGACGGCCGGTGTC
GGTGCTGGAGATGGTGCGCGGCTTCGAGCAGGCCAGCGGCCGTGCCGTGCCCTACCAGGTGGTGGCGCGCCGCCCCGGCG
ACGTTGCCGCCTGCTGGGCCGACCCAGCCCAGGCCGAGCGCCTGCTGGGCTGGCGCGCGCGACGCGACGTGCAGGCCATG
TGCCGGGATGCCTGGCGCTGGCAGGATGGCGAGGCGCGCCGACTGGGTGATGCTCCTTGA

Upstream 100 bases:

>100_bases
AAGCCAAGGTTACCCGATTACAACGCGCCCCGGCCTCACGCGGTTGAATGAAGTCCGGCGGTACAGTCATGCCTTTGGGC
ATTTTCGAGGACGAGAGGAC

Downstream 100 bases:

>100_bases
TTGATAGCTGGTCGCGCTCGTCAGTCAAGGAATTGATGGGGGAAATGGTTTGGAAACCAAATCCGACGAGCGCGAAAAGC
TATTGATTCAATAGCTGAGC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MILVTGGAGFIGTHTCAALADAGIPTLLLDNFSNSRRSVLDRLARITGKPVACVEGDVRDAQLLRQLFASHPIEGVIHFA
ALKAVGESVREPLRYYENNVAGTVSLLRAMQAAGVRTLVFSSSATVYGDPASLPIREDFPLSATNPYGWSKLMMEQVLAD
VDHAEPGQWRIARLRYFNPVGAHESGLIGEDPQDIPNNLMPYVAQVATGQREVLSVYGGDYPTPDGTGVRDYIHVCDLAE
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEQASGRAVPYQVVARRPGDVAACWADPAQAERLLGWRARRDVQAM
CRDAWRWQDGEARRLGDAP

Sequences:

>Translated_339_residues
MILVTGGAGFIGTHTCAALADAGIPTLLLDNFSNSRRSVLDRLARITGKPVACVEGDVRDAQLLRQLFASHPIEGVIHFA
ALKAVGESVREPLRYYENNVAGTVSLLRAMQAAGVRTLVFSSSATVYGDPASLPIREDFPLSATNPYGWSKLMMEQVLAD
VDHAEPGQWRIARLRYFNPVGAHESGLIGEDPQDIPNNLMPYVAQVATGQREVLSVYGGDYPTPDGTGVRDYIHVCDLAE
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEQASGRAVPYQVVARRPGDVAACWADPAQAERLLGWRARRDVQAM
CRDAWRWQDGEARRLGDAP
>Mature_339_residues
MILVTGGAGFIGTHTCAALADAGIPTLLLDNFSNSRRSVLDRLARITGKPVACVEGDVRDAQLLRQLFASHPIEGVIHFA
ALKAVGESVREPLRYYENNVAGTVSLLRAMQAAGVRTLVFSSSATVYGDPASLPIREDFPLSATNPYGWSKLMMEQVLAD
VDHAEPGQWRIARLRYFNPVGAHESGLIGEDPQDIPNNLMPYVAQVATGQREVLSVYGGDYPTPDGTGVRDYIHVCDLAE
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEQASGRAVPYQVVARRPGDVAACWADPAQAERLLGWRARRDVQAM
CRDAWRWQDGEARRLGDAP

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=334, Percent_Identity=55.0898203592814, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI56118217, Length=334, Percent_Identity=55.0898203592814, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI189083684, Length=334, Percent_Identity=55.0898203592814, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI7657641, Length=326, Percent_Identity=26.0736196319018, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=25.7142857142857, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1786974, Length=328, Percent_Identity=55.1829268292683, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI48994969, Length=361, Percent_Identity=26.8698060941828, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71982038, Length=339, Percent_Identity=50.1474926253687, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI71982035, Length=337, Percent_Identity=50.4451038575668, Blast_Score=338, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319493, Length=335, Percent_Identity=50.1492537313433, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI19923002, Length=336, Percent_Identity=53.5714285714286, Blast_Score=358, Evalue=2e-99,
Organism=Drosophila melanogaster, GI21356223, Length=318, Percent_Identity=22.6415094339623, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36851; Mature: 36851

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGFIGTHTCAALADAGIPTLLLDNFSNSRRSVLDRLARITGKPVACVEGDVRD
CEEEECCCCCHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHCCCCEEEECCCCHH
AQLLRQLFASHPIEGVIHFAALKAVGESVREPLRYYENNVAGTVSLLRAMQAAGVRTLVF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEE
SSSATVYGDPASLPIREDFPLSATNPYGWSKLMMEQVLADVDHAEPGQWRIARLRYFNPV
ECCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
GAHESGLIGEDPQDIPNNLMPYVAQVATGQREVLSVYGGDYPTPDGTGVRDYIHVCDLAE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCC
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEQASGRAVPYQVVARRPGDVAACWA
CHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECC
DPAQAERLLGWRARRDVQAMCRDAWRWQDGEARRLGDAP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MILVTGGAGFIGTHTCAALADAGIPTLLLDNFSNSRRSVLDRLARITGKPVACVEGDVRD
CEEEECCCCCHHHHHHHHHHHCCCCCEEHHCCCCHHHHHHHHHHHHCCCCEEEECCCCHH
AQLLRQLFASHPIEGVIHFAALKAVGESVREPLRYYENNVAGTVSLLRAMQAAGVRTLVF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEE
SSSATVYGDPASLPIREDFPLSATNPYGWSKLMMEQVLADVDHAEPGQWRIARLRYFNPV
ECCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
GAHESGLIGEDPQDIPNNLMPYVAQVATGQREVLSVYGGDYPTPDGTGVRDYIHVCDLAE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCC
GHVAALRYLRAHPGLLTVNLGTGRPVSVLEMVRGFEQASGRAVPYQVVARRPGDVAACWA
CHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECC
DPAQAERLLGWRARRDVQAMCRDAWRWQDGEARRLGDAP
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]