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The map label for this gene is hisG

Identifier: 222109941

GI number: 222109941

Start: 756362

End: 757012

Strand: Direct

Name: hisG

Synonym: Dtpsy_0726

Alternate gene names: 222109941

Gene position: 756362-757012 (Clockwise)

Preceding gene: 222109940

Following gene: 222109942

Centisome position: 19.92

GC content: 65.59

Gene sequence:

>651_bases
ATGACGCAGCAGATCACACTCGCCCTGTCCAAGGGCCGCATCTTCGAAGAAACCCTGCCTCTGCTGGCCGCTGCCGGCAT
CGAGGTGCTGGAAGACCCGGAGAAGTCGCGCAAGCTCATCCTGCCCACCAGCCGCCCCGAGGTGCGCGTGGTGCTGGTGC
GTGCCACCGACGTGCCGACCTACGTGCAATACGGCGGCGCCGATCTGGGTGTGGCCGGCAAGGACTCGCTCATCGAGCAC
GGCGGCCAAGGGCTGTTCCGCCCGCTGGATCTGAAGATTGCCAAGTGCCGCGTGAGCGTGGCCGTGCGCGCCGATTTCGA
CTACCGCGAGGCCGTCACCCAGGGCTCACGCCTGAAGGTGGCCACCAAATACACCAGCATCGCGCGCGATTTCTTCGCCA
GCAAGGGCGTGCACGTGGACCTCATCAAGCTCTACGGCAGCATGGAACTGGCGCCGCTCACCGGCCTGGCCGATGCCATC
GTGGACTTGGTCTCCACTGGCAACACGCTCAAGGCCAACAACCTGGTGGAGGTCGAGCAGATCATGGACATCAGTTCGCA
CCTGGTGGTGAACCAGGCCGCGCTGAAGCTGAAGCAGGCGCCGCTGCGCCGCATCATCGACGCATTCGCCTCCGCCGTGC
CGCAGGGCTGA

Upstream 100 bases:

>100_bases
ACGGGGAAACGCTGGTGGACCGCATCTACCATCTGGACCGCGGCTACGACTGCATGGAAGCCAAACTGCGCGGCCTGGGG
GCCGACATCGAGAGAATTCA

Downstream 100 bases:

>100_bases
GGGGTGCGCAGGGCTGCGTCTGCGCCGCTTTGGTTCCGCGTCCATCGCCCGGCATTGCAACCGCGCGCCGTGGCCCGAGT
TATGGTGAGAACATCGTGGC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTQQITLALSKGRIFEETLPLLAAAGIEVLEDPEKSRKLILPTSRPEVRVVLVRATDVPTYVQYGGADLGVAGKDSLIEH
GGQGLFRPLDLKIAKCRVSVAVRADFDYREAVTQGSRLKVATKYTSIARDFFASKGVHVDLIKLYGSMELAPLTGLADAI
VDLVSTGNTLKANNLVEVEQIMDISSHLVVNQAALKLKQAPLRRIIDAFASAVPQG

Sequences:

>Translated_216_residues
MTQQITLALSKGRIFEETLPLLAAAGIEVLEDPEKSRKLILPTSRPEVRVVLVRATDVPTYVQYGGADLGVAGKDSLIEH
GGQGLFRPLDLKIAKCRVSVAVRADFDYREAVTQGSRLKVATKYTSIARDFFASKGVHVDLIKLYGSMELAPLTGLADAI
VDLVSTGNTLKANNLVEVEQIMDISSHLVVNQAALKLKQAPLRRIIDAFASAVPQG
>Mature_215_residues
TQQITLALSKGRIFEETLPLLAAAGIEVLEDPEKSRKLILPTSRPEVRVVLVRATDVPTYVQYGGADLGVAGKDSLIEHG
GQGLFRPLDLKIAKCRVSVAVRADFDYREAVTQGSRLKVATKYTSIARDFFASKGVHVDLIKLYGSMELAPLTGLADAIV
DLVSTGNTLKANNLVEVEQIMDISSHLVVNQAALKLKQAPLRRIIDAFASAVPQG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=187, Percent_Identity=33.6898395721925, Blast_Score=88, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=198, Percent_Identity=29.2929292929293, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ACIET (B9MDV1)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552205.1
- ProteinModelPortal:   B9MDV1
- SMR:   B9MDV1
- GeneID:   7384231
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0726
- ProtClustDB:   PRK01686
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23336; Mature: 23205

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQITLALSKGRIFEETLPLLAAAGIEVLEDPEKSRKLILPTSRPEVRVVLVRATDVPT
CCCEEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEECCCCCCEEEEEEEECCCCH
YVQYGGADLGVAGKDSLIEHGGQGLFRPLDLKIAKCRVSVAVRADFDYREAVTQGSRLKV
HHHCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHCCCCEEEE
ATKYTSIARDFFASKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGNTLKANNLVEVEQ
EHHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHCCCEECCCCEEHHHH
IMDISSHLVVNQAALKLKQAPLRRIIDAFASAVPQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQQITLALSKGRIFEETLPLLAAAGIEVLEDPEKSRKLILPTSRPEVRVVLVRATDVPT
CCEEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEECCCCCCEEEEEEEECCCCH
YVQYGGADLGVAGKDSLIEHGGQGLFRPLDLKIAKCRVSVAVRADFDYREAVTQGSRLKV
HHHCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHCCCCEEEE
ATKYTSIARDFFASKGVHVDLIKLYGSMELAPLTGLADAIVDLVSTGNTLKANNLVEVEQ
EHHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHCCCEECCCCEEHHHH
IMDISSHLVVNQAALKLKQAPLRRIIDAFASAVPQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA