Click here to switch to the map view.

The map label for this gene is murA

Identifier: 222109940

GI number: 222109940

Start: 755043

End: 756365

Strand: Direct

Name: murA

Synonym: Dtpsy_0725

Alternate gene names: 222109940

Gene position: 755043-756365 (Clockwise)

Preceding gene: 222109939

Following gene: 222109941

Centisome position: 19.89

GC content: 70.14

Gene sequence:

>1323_bases
ATGGACAAACTCCTGATTCGCGGTGGCCGCCCCCTGGTGGGCGAGGTGCCGATTTCCGGCGCCAAGAACGCCGCGCTGCC
CGAGCTGTGCGCCGCGCTGCTCACGGCCGACCCGGTCACCCTGCACAACGTGCCGCGCCTGCAGGACGTAGCCACCATGC
TGCGGCTCATCCGGAACATGGGCGTGCAGGTGGACCGCATCGCTAACCCCGACTGCTCCGTGGCCGATGCGGCCGGCATA
GTGCGCCTGGACGCGGGCGCCCTGTCCACGCCTGAGGCGCCCTACGATCTGGTCAAGACCATGCGCGCCTCGGTACTGGC
GCTGGGGCCGCTGCTGGCGCGTTTCGGCGAGGCCACGGTGTCGCTGCCGGGCGGCTGCGCCATCGGATCGCGCCCGGTGG
ATCAGCACATCAAGGGGCTGCAGGCCATGGGCGCGCAGATCGTGGTCGAGCACGGCTACATGATCGCCAGGCTGCCGCAG
GGGTGCACGCGACTCAGGGGGGCGCGCATCACCACCGACATGGTCACGGTGACCGGCACCGAGAATCTGCTCATGGCCGC
CACGCTGGCTGAGGGGGAGACCGTGCTGGAGAACGCCGCGCAGGAACCCGAGGTGGCGGACCTGGCCGAGATGCTCATCA
AGATGGGCGCGCGTATCGAGGGCCATGGCACCAGCCGCATCCGCATCCAGGGGGTCGAGCGGCTGCACGGCTGCGAGCAC
GCCGTCGTGGCCGACCGCATCGAGGCCGGCACCTTCCTGTGCGCCGTGGCCGCCACGGGCGGCGACGCGCTGCTGCGCCA
CGGGCGTGCCGACCACCTGGACGCCGTGATCGACAAACTGCGCGACGCGGGCGTGCAGGTGGCGCCGGAAGAGGGTGGCA
TCCGCGTGCGCAGCCCTGGCGCGGCGCAGCTCAAGGCGCAGGGCTTTCGCACCACTGAGTACCCGGGCTTTCCCACCGAC
ATGCAGGCGCAGTTCATGGCGCTGAACGTGGTGGCCCAGGGCACCGCCACGGTGGCCGAGACGATCTTCGAGAACCGTTT
CATGCACGTCAACGAGTTGTTGCGCCTTGGCGCGAAAATCCAGACCACGGATGGCCGCGTAGCGGTGATCGAGGGGCTGG
GCGGCGCGGCGCCTGCGGGGGCGCGGCTGTCGGGCGCCACCGTCATGGCCACCGACCTGCGCGCCTCGGCCAGCCTGGTG
ATCGCCGGCTTGGTGGCCGACGGGGAAACGCTGGTGGACCGCATCTACCATCTGGACCGCGGCTACGACTGCATGGAAGC
CAAACTGCGCGGCCTGGGGGCCGACATCGAGAGAATTCAATGA

Upstream 100 bases:

>100_bases
CCCCCAAAGAATTCGCGCACTATTATTTTAATAGCTGCTACCGCTTGATAGATAAGCGCTAGAGCCATTTTTGGCACTGA
ATGCAGCAACCGGCAAACCC

Downstream 100 bases:

>100_bases
CGCAGCAGATCACACTCGCCCTGTCCAAGGGCCGCATCTTCGAAGAAACCCTGCCTCTGCTGGCCGCTGCCGGCATCGAG
GTGCTGGAAGACCCGGAGAA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MDKLLIRGGRPLVGEVPISGAKNAALPELCAALLTADPVTLHNVPRLQDVATMLRLIRNMGVQVDRIANPDCSVADAAGI
VRLDAGALSTPEAPYDLVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLQAMGAQIVVEHGYMIARLPQ
GCTRLRGARITTDMVTVTGTENLLMAATLAEGETVLENAAQEPEVADLAEMLIKMGARIEGHGTSRIRIQGVERLHGCEH
AVVADRIEAGTFLCAVAATGGDALLRHGRADHLDAVIDKLRDAGVQVAPEEGGIRVRSPGAAQLKAQGFRTTEYPGFPTD
MQAQFMALNVVAQGTATVAETIFENRFMHVNELLRLGAKIQTTDGRVAVIEGLGGAAPAGARLSGATVMATDLRASASLV
IAGLVADGETLVDRIYHLDRGYDCMEAKLRGLGADIERIQ

Sequences:

>Translated_440_residues
MDKLLIRGGRPLVGEVPISGAKNAALPELCAALLTADPVTLHNVPRLQDVATMLRLIRNMGVQVDRIANPDCSVADAAGI
VRLDAGALSTPEAPYDLVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLQAMGAQIVVEHGYMIARLPQ
GCTRLRGARITTDMVTVTGTENLLMAATLAEGETVLENAAQEPEVADLAEMLIKMGARIEGHGTSRIRIQGVERLHGCEH
AVVADRIEAGTFLCAVAATGGDALLRHGRADHLDAVIDKLRDAGVQVAPEEGGIRVRSPGAAQLKAQGFRTTEYPGFPTD
MQAQFMALNVVAQGTATVAETIFENRFMHVNELLRLGAKIQTTDGRVAVIEGLGGAAPAGARLSGATVMATDLRASASLV
IAGLVADGETLVDRIYHLDRGYDCMEAKLRGLGADIERIQ
>Mature_440_residues
MDKLLIRGGRPLVGEVPISGAKNAALPELCAALLTADPVTLHNVPRLQDVATMLRLIRNMGVQVDRIANPDCSVADAAGI
VRLDAGALSTPEAPYDLVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLQAMGAQIVVEHGYMIARLPQ
GCTRLRGARITTDMVTVTGTENLLMAATLAEGETVLENAAQEPEVADLAEMLIKMGARIEGHGTSRIRIQGVERLHGCEH
AVVADRIEAGTFLCAVAATGGDALLRHGRADHLDAVIDKLRDAGVQVAPEEGGIRVRSPGAAQLKAQGFRTTEYPGFPTD
MQAQFMALNVVAQGTATVAETIFENRFMHVNELLRLGAKIQTTDGRVAVIEGLGGAAPAGARLSGATVMATDLRASASLV
IAGLVADGETLVDRIYHLDRGYDCMEAKLRGLGADIERIQ

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=440, Percent_Identity=53.1818181818182, Blast_Score=426, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_ACIET (B9MDV0)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552204.1
- GeneID:   7384230
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0725
- ProtClustDB:   PRK09369
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 46284; Mature: 46284

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: ACT_SITE 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLLIRGGRPLVGEVPISGAKNAALPELCAALLTADPVTLHNVPRLQDVATMLRLIRNM
CCCEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHC
GVQVDRIANPDCSVADAAGIVRLDAGALSTPEAPYDLVKTMRASVLALGPLLARFGEATV
CCEEEECCCCCCCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
SLPGGCAIGSRPVDQHIKGLQAMGAQIVVEHGYMIARLPQGCTRLRGARITTDMVTVTGT
ECCCCCCCCCCCHHHHHHHHHHCCCEEEEECCEEEEECCHHHHHHCCCEEEEEEEEEECC
ENLLMAATLAEGETVLENAAQEPEVADLAEMLIKMGARIEGHGTSRIRIQGVERLHGCEH
CCEEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEECHHHHCCCCH
AVVADRIEAGTFLCAVAATGGDALLRHGRADHLDAVIDKLRDAGVQVAPEEGGIRVRSPG
HHHHHHHCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHCCCEECCCCCCEEEECCC
AAQLKAQGFRTTEYPGFPTDMQAQFMALNVVAQGTATVAETIFENRFMHVNELLRLGAKI
CCHHHHCCCCCCCCCCCCCCHHHHHHEEEHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEE
QTTDGRVAVIEGLGGAAPAGARLSGATVMATDLRASASLVIAGLVADGETLVDRIYHLDR
EECCCCEEEEECCCCCCCCCCCCCCCEEEEECHHCCCEEEEEEEECCCHHHHHHHHHHCC
GYDCMEAKLRGLGADIERIQ
CCHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MDKLLIRGGRPLVGEVPISGAKNAALPELCAALLTADPVTLHNVPRLQDVATMLRLIRNM
CCCEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHC
GVQVDRIANPDCSVADAAGIVRLDAGALSTPEAPYDLVKTMRASVLALGPLLARFGEATV
CCEEEECCCCCCCCHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
SLPGGCAIGSRPVDQHIKGLQAMGAQIVVEHGYMIARLPQGCTRLRGARITTDMVTVTGT
ECCCCCCCCCCCHHHHHHHHHHCCCEEEEECCEEEEECCHHHHHHCCCEEEEEEEEEECC
ENLLMAATLAEGETVLENAAQEPEVADLAEMLIKMGARIEGHGTSRIRIQGVERLHGCEH
CCEEEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHCCEEECCCCCEEEEECHHHHCCCCH
AVVADRIEAGTFLCAVAATGGDALLRHGRADHLDAVIDKLRDAGVQVAPEEGGIRVRSPG
HHHHHHHCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHCCCEECCCCCCEEEECCC
AAQLKAQGFRTTEYPGFPTDMQAQFMALNVVAQGTATVAETIFENRFMHVNELLRLGAKI
CCHHHHCCCCCCCCCCCCCCHHHHHHEEEHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEE
QTTDGRVAVIEGLGGAAPAGARLSGATVMATDLRASASLVIAGLVADGETLVDRIYHLDR
EECCCCEEEEECCCCCCCCCCCCCCCEEEEECHHCCCEEEEEEEECCCHHHHHHHHHHCC
GYDCMEAKLRGLGADIERIQ
CCHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA