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The map label for this gene is yahK [H]

Identifier: 222109840

GI number: 222109840

Start: 643321

End: 644382

Strand: Direct

Name: yahK [H]

Synonym: Dtpsy_0624

Alternate gene names: 222109840

Gene position: 643321-644382 (Clockwise)

Preceding gene: 222109838

Following gene: 222109842

Centisome position: 16.94

GC content: 65.63

Gene sequence:

>1062_bases
ATGACCGTCAAAGCCTACGGCGCCCATGCGAGCGACCGTCCATTGCAGCCCCTGGAGATCGCACGGCGCGCGCCGGGCGC
GCACGACGTGCAGATTGGCATTGCCTATTGCGGTGTGTGCCATTCCGATCTGCACCAGGTGCGTTCGGAATGGGCGGGCA
CGCTGTATCCGTGCGTGCCGGGGCATGAAATCGTCGGGCGCGTAGTGGCCGTGGGCGCGCAGGTGTCGGCGTTCCGGGCG
GGCGACCTGGTCGGCGTGGGCTGCATTGTCGACAGCTGCCGGCATTGCCAGGATTGCGACGAAGGGCTGGAGAACTATTG
CGGCCACATGGTCGGCACCTACAACGGCCCGACCGAGGACGCACCCGGCCACACGCTGGGTGGGTACTCGCAACAGATCG
TCGTACATGAGCGCTATGTGCTGCGGGTGCGCCATCCGCAAGGGCAGTTGGCCGCGGTTGCTCCGCTGCTGTGCGCGGGC
ATTACCACCTACTCGCCCTTGCGCCATTGGAAGGTGGGTCCGGGGCATCGCGTGGGTGTGGTCGGCATCGGCGGGCTGGG
CCACCTGGGCATCAAGCTGGCGCACGCAATGGGGGCGCATGTGGTGGCATTCACCACCTCTGAATCCAAGCGCGCTGCGG
CGCTCTCGTTAGGTGCGCACGAAGTGGTGGTTTCCCGTCATCCGCAGGAGATGGCCGCGCATGCCAACAGTCTCGACTTC
ATCCTCAACACGGTGGCGGCGCCGCACGACCTGGATGCCTTCCTGCGCCTGCTGCGGCGCGACGGTGCGATGACGCTGGT
GGGTGCGCCGGCGTCGCCCCATCCGTCGCCCAATGTGTTCAACCTCATCATGAAGCGGCGCACGCTGGCTGGCTCCTTGA
TCGGCGGCATTCCCGAGACCCAGGAGATGCTCGATTTCTGCGCGGAGCATGGCATCGTGGCGGATATCGAGTTGATCCGC
GCCGATGAGATCAATACCGCCTATGAACGCATGTTGAAGGGCGACGTGCAATACCGCTTCGTCATCGACATCGCCACGCT
GGCCGAATCGGCCGGGGCCTAG

Upstream 100 bases:

>100_bases
AGGCCCTGCCTCAGGCCGGAAGTGCCGATAGGATTCTGTTCCGAAACGCATCGGACCGAACCTGTACAACAGGGGCGTGA
GCCATTCACAGGAGAACCCC

Downstream 100 bases:

>100_bases
CGGCGATGGGGCGAGGGGCGGCGCGGTGCGCCGCCGGCACGCGGCTCCAGGTGGCGGAAGGTGATACGGCCCTTGGTGAG
GTCGTAGGGGGACATCTCCA

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTVKAYGAHASDRPLQPLEIARRAPGAHDVQIGIAYCGVCHSDLHQVRSEWAGTLYPCVPGHEIVGRVVAVGAQVSAFRA
GDLVGVGCIVDSCRHCQDCDEGLENYCGHMVGTYNGPTEDAPGHTLGGYSQQIVVHERYVLRVRHPQGQLAAVAPLLCAG
ITTYSPLRHWKVGPGHRVGVVGIGGLGHLGIKLAHAMGAHVVAFTTSESKRAAALSLGAHEVVVSRHPQEMAAHANSLDF
ILNTVAAPHDLDAFLRLLRRDGAMTLVGAPASPHPSPNVFNLIMKRRTLAGSLIGGIPETQEMLDFCAEHGIVADIELIR
ADEINTAYERMLKGDVQYRFVIDIATLAESAGA

Sequences:

>Translated_353_residues
MTVKAYGAHASDRPLQPLEIARRAPGAHDVQIGIAYCGVCHSDLHQVRSEWAGTLYPCVPGHEIVGRVVAVGAQVSAFRA
GDLVGVGCIVDSCRHCQDCDEGLENYCGHMVGTYNGPTEDAPGHTLGGYSQQIVVHERYVLRVRHPQGQLAAVAPLLCAG
ITTYSPLRHWKVGPGHRVGVVGIGGLGHLGIKLAHAMGAHVVAFTTSESKRAAALSLGAHEVVVSRHPQEMAAHANSLDF
ILNTVAAPHDLDAFLRLLRRDGAMTLVGAPASPHPSPNVFNLIMKRRTLAGSLIGGIPETQEMLDFCAEHGIVADIELIR
ADEINTAYERMLKGDVQYRFVIDIATLAESAGA
>Mature_352_residues
TVKAYGAHASDRPLQPLEIARRAPGAHDVQIGIAYCGVCHSDLHQVRSEWAGTLYPCVPGHEIVGRVVAVGAQVSAFRAG
DLVGVGCIVDSCRHCQDCDEGLENYCGHMVGTYNGPTEDAPGHTLGGYSQQIVVHERYVLRVRHPQGQLAAVAPLLCAGI
TTYSPLRHWKVGPGHRVGVVGIGGLGHLGIKLAHAMGAHVVAFTTSESKRAAALSLGAHEVVVSRHPQEMAAHANSLDFI
LNTVAAPHDLDAFLRLLRRDGAMTLVGAPASPHPSPNVFNLIMKRRTLAGSLIGGIPETQEMLDFCAEHGIVADIELIRA
DEINTAYERMLKGDVQYRFVIDIATLAESAGA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=354, Percent_Identity=26.8361581920904, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI71565152, Length=323, Percent_Identity=26.0061919504644, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501929, Length=311, Percent_Identity=27.6527331189711, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI34577061, Length=321, Percent_Identity=27.7258566978193, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4501939, Length=355, Percent_Identity=25.0704225352113, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156523966, Length=356, Percent_Identity=25, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71565154, Length=376, Percent_Identity=25.531914893617, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=78.7965616045845, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI87082401, Length=345, Percent_Identity=35.3623188405797, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI87081918, Length=314, Percent_Identity=28.6624203821656, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=26.9541778975741, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788407, Length=280, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI226510992, Length=270, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=28.6135693215339, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=28.8629737609329, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=28.1524926686217, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=27.9132791327913, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=27.7628032345013, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=32.1739130434783, Blast_Score=165, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=30.945558739255, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323961, Length=353, Percent_Identity=32.5779036827195, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323980, Length=323, Percent_Identity=34.984520123839, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=30.3951367781155, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=34.441087613293, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320033, Length=365, Percent_Identity=28.7671232876712, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=346, Percent_Identity=23.6994219653179, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=366, Percent_Identity=24.8633879781421, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 37618; Mature: 37486

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKAYGAHASDRPLQPLEIARRAPGAHDVQIGIAYCGVCHSDLHQVRSEWAGTLYPCVP
CEEEECCCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCEECCCCC
GHEIVGRVVAVGAQVSAFRAGDLVGVGCIVDSCRHCQDCDEGLENYCGHMVGTYNGPTED
CHHHHHHHHHHCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCC
APGHTLGGYSQQIVVHERYVLRVRHPQGQLAAVAPLLCAGITTYSPLRHWKVGPGHRVGV
CCCCCCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHCCHHCCCHHHCCCCCCCEEEE
VGIGGLGHLGIKLAHAMGAHVVAFTTSESKRAAALSLGAHEVVVSRHPQEMAAHANSLDF
EEECCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCHHHHHHCCHHHHHHHCCHHHH
ILNTVAAPHDLDAFLRLLRRDGAMTLVGAPASPHPSPNVFNLIMKRRTLAGSLIGGIPET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
QEMLDFCAEHGIVADIELIRADEINTAYERMLKGDVQYRFVIDIATLAESAGA
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEEEEHHHHHHHCCC
>Mature Secondary Structure 
TVKAYGAHASDRPLQPLEIARRAPGAHDVQIGIAYCGVCHSDLHQVRSEWAGTLYPCVP
EEEECCCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCEECCCCC
GHEIVGRVVAVGAQVSAFRAGDLVGVGCIVDSCRHCQDCDEGLENYCGHMVGTYNGPTED
CHHHHHHHHHHCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCC
APGHTLGGYSQQIVVHERYVLRVRHPQGQLAAVAPLLCAGITTYSPLRHWKVGPGHRVGV
CCCCCCCCCCCEEEEEEEEEEEEECCCCCHHHHHHHHHHCCHHCCCHHHCCCCCCCEEEE
VGIGGLGHLGIKLAHAMGAHVVAFTTSESKRAAALSLGAHEVVVSRHPQEMAAHANSLDF
EEECCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCHHHHHHCCHHHHHHHCCHHHH
ILNTVAAPHDLDAFLRLLRRDGAMTLVGAPASPHPSPNVFNLIMKRRTLAGSLIGGIPET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
QEMLDFCAEHGIVADIELIRADEINTAYERMLKGDVQYRFVIDIATLAESAGA
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]