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The map label for this gene is lig [H]

Identifier: 222109526

GI number: 222109526

Start: 314333

End: 316012

Strand: Direct

Name: lig [H]

Synonym: Dtpsy_0306

Alternate gene names: 222109526

Gene position: 314333-316012 (Clockwise)

Preceding gene: 222109525

Following gene: 222109527

Centisome position: 8.28

GC content: 71.07

Gene sequence:

>1680_bases
ATGCAGGCCTTTGCCGCGCTCTACCAGGCGTTGGATGCCAGCACGTCCAGCCTCGCCAAGCAGGCCGCGCTGCGCGACTA
TCTGCGGGGTGCGCCACCCGAGGATGCCGCCTGGGCCGTCTACTTCCTCGCGGGTGGCAAACCACGCCAACTCGTGCCCA
CCAAGCTGCTGCGCGCGGTGGCGCGCGAGGCGGCGGGGTTGCCGGAATGGCTGTTCGACGAAAGCTACGAGGCTGTGGGC
GATCTGGCCGAGACCATCGCACTGCTGTTGCCCCCGCCCACGCAGGCTCACGCCCTGGGGCTGGCCGCATGGATGCGCGA
ACACCTCTTGCCGCTGCGCGGCCTGGCGCCCGACACCCAGGCTGAACGACTGGGTGCGCAATGGGCGCGGCTGGCGCCCG
AGGAGCGGCTGGTGTACTTCAAGCTCATCACGGGGGCCTTCCGCGTGGGCGTGTCGCGCTTGCAGGTCACGCAGGCGCTC
GCGGCCGTGAGCGGCGTGGACGCCAAGCGCATCGCCCAGCGCCTCATGGGCTACACCCACGTGGGCGCGCAGCCCGGGGC
GGCTGACTACCAGCGCCTCGTGGCGCCCGAGGGAGACAGTGCGGGCGCGCAGGCTGCGGAGGCCCAGGGCCATCCCTATC
CCTTCTTTCTGGCGCACCCGCTGCAACTGCCGGTGGCGCAGTTTGACGCCGCGCTCGGCCCGCCGGCGGACTGGATCGTG
GAATGGAAGTGGGACGGCATCCGCGCCCAGCTCGTGCGGCGCGCTGGCGCCACTTGGCTGTGGTCGCGCGGGGAGGAGTT
GGTGACCGATCGCTTCCCCGAGCTGCAGGCGTTGGGCGACGAAGCCCTGCCCGACGGCACGGTGCTCGACGGCGAGATCG
TCGTCTGGCAGCCCGCGCGAGCGGATGCGCCGGCGCAGCCGCGCCCGTTTGCCGACCTGCAAAAGCGCATCGGCCGCAAG
TCGCTGGGCTCCAAGCTGCTGCGCGAGGTGCCCGTAGTGCTGTTGGCCTACGACCTGCTGGAGGAGCACGGCCAGGACCT
GCGCGGCCTGCCGCTGCAGGCGCGGCGCGCGCGGCTGGACGCGCTGCTGGCGCGCACCGACCACCCGGCGCTGGTGCCCA
GCCCGGTGCTGCAGGGACAGAGCTGGGCCGAACTGGCACGCCTGCGGGACAGTGCGCGTGCCCTGGGCGTGGAGGGCATG
ATGCTCAAAAGGCGCACGGCGCACTATGGTGTGGGCCGCACCCGGGACGTGGGCATCTGGTGGAAGTGGAAGATCGACCC
GATGAGCGTGGACGCCGTGCTCATTTATGCGCAGCGCGGCCACGGGCGCCGCGCCAGCCTGTACAGCGACTACACGTTCG
CCGTGTGGAGTGCGCCGCAGGGCACCGAGGGGCGCACGCTGGTGCCGTTTGCCAAGGCGTATTCGGGCCTGACCGATGCC
GAGATGGCGAGGGTGGACGCCATCATCCGCAAGACCACGGTGGAGAGCTTCGGCCCGGTGCGCAGCGTGCGGCCCACGCT
GGTGTTCGAGCTGGGCTTTGAGGGCATAGCGCGCAGCGCGCGGCACAAGAGCGGCATCGCCGTGCGCTTCCCGCGCATGC
TGCGCTGGCGTGAGGACAAGCCGGTGGACGAAGCCGATTCGCTGGATACGCTGGCGGCGCTGTTGCCTGCTACGTCATGA

Upstream 100 bases:

>100_bases
AATACGGCGACGAGGACGAGGCCGCGCCGACCGACGCGCCAACTGCAGCGCCCACTGCACCGGAAGGCGACGCAGGCGAC
GCGGCCGGAGGCACCTCCTG

Downstream 100 bases:

>100_bases
TCTGGCGCTATGAATACAAGAGCTGTTGGCGCTGGATGGATGGGCGCTGCAGGCGATTTTCCCTCGAAACGCCATGGCCC
GTGCGGCGGCAATGCCTTGG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MQAFAALYQALDASTSSLAKQAALRDYLRGAPPEDAAWAVYFLAGGKPRQLVPTKLLRAVAREAAGLPEWLFDESYEAVG
DLAETIALLLPPPTQAHALGLAAWMREHLLPLRGLAPDTQAERLGAQWARLAPEERLVYFKLITGAFRVGVSRLQVTQAL
AAVSGVDAKRIAQRLMGYTHVGAQPGAADYQRLVAPEGDSAGAQAAEAQGHPYPFFLAHPLQLPVAQFDAALGPPADWIV
EWKWDGIRAQLVRRAGATWLWSRGEELVTDRFPELQALGDEALPDGTVLDGEIVVWQPARADAPAQPRPFADLQKRIGRK
SLGSKLLREVPVVLLAYDLLEEHGQDLRGLPLQARRARLDALLARTDHPALVPSPVLQGQSWAELARLRDSARALGVEGM
MLKRRTAHYGVGRTRDVGIWWKWKIDPMSVDAVLIYAQRGHGRRASLYSDYTFAVWSAPQGTEGRTLVPFAKAYSGLTDA
EMARVDAIIRKTTVESFGPVRSVRPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDKPVDEADSLDTLAALLPATS

Sequences:

>Translated_559_residues
MQAFAALYQALDASTSSLAKQAALRDYLRGAPPEDAAWAVYFLAGGKPRQLVPTKLLRAVAREAAGLPEWLFDESYEAVG
DLAETIALLLPPPTQAHALGLAAWMREHLLPLRGLAPDTQAERLGAQWARLAPEERLVYFKLITGAFRVGVSRLQVTQAL
AAVSGVDAKRIAQRLMGYTHVGAQPGAADYQRLVAPEGDSAGAQAAEAQGHPYPFFLAHPLQLPVAQFDAALGPPADWIV
EWKWDGIRAQLVRRAGATWLWSRGEELVTDRFPELQALGDEALPDGTVLDGEIVVWQPARADAPAQPRPFADLQKRIGRK
SLGSKLLREVPVVLLAYDLLEEHGQDLRGLPLQARRARLDALLARTDHPALVPSPVLQGQSWAELARLRDSARALGVEGM
MLKRRTAHYGVGRTRDVGIWWKWKIDPMSVDAVLIYAQRGHGRRASLYSDYTFAVWSAPQGTEGRTLVPFAKAYSGLTDA
EMARVDAIIRKTTVESFGPVRSVRPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDKPVDEADSLDTLAALLPATS
>Mature_559_residues
MQAFAALYQALDASTSSLAKQAALRDYLRGAPPEDAAWAVYFLAGGKPRQLVPTKLLRAVAREAAGLPEWLFDESYEAVG
DLAETIALLLPPPTQAHALGLAAWMREHLLPLRGLAPDTQAERLGAQWARLAPEERLVYFKLITGAFRVGVSRLQVTQAL
AAVSGVDAKRIAQRLMGYTHVGAQPGAADYQRLVAPEGDSAGAQAAEAQGHPYPFFLAHPLQLPVAQFDAALGPPADWIV
EWKWDGIRAQLVRRAGATWLWSRGEELVTDRFPELQALGDEALPDGTVLDGEIVVWQPARADAPAQPRPFADLQKRIGRK
SLGSKLLREVPVVLLAYDLLEEHGQDLRGLPLQARRARLDALLARTDHPALVPSPVLQGQSWAELARLRDSARALGVEGM
MLKRRTAHYGVGRTRDVGIWWKWKIDPMSVDAVLIYAQRGHGRRASLYSDYTFAVWSAPQGTEGRTLVPFAKAYSGLTDA
EMARVDAIIRKTTVESFGPVRSVRPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDKPVDEADSLDTLAALLPATS

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=376, Percent_Identity=26.063829787234, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71985269, Length=393, Percent_Identity=26.7175572519084, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24762424, Length=352, Percent_Identity=27.5568181818182, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI85815841, Length=364, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 61334; Mature: 61334

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00024 HEMOPEXIN ; PS00177 TOPOISOMERASE_II ; PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAFAALYQALDASTSSLAKQAALRDYLRGAPPEDAAWAVYFLAGGKPRQLVPTKLLRAV
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
AREAAGLPEWLFDESYEAVGDLAETIALLLPPPTQAHALGLAAWMREHLLPLRGLAPDTQ
HHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHCCCCCCHH
AERLGAQWARLAPEERLVYFKLITGAFRVGVSRLQVTQALAAVSGVDAKRIAQRLMGYTH
HHHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
VGAQPGAADYQRLVAPEGDSAGAQAAEAQGHPYPFFLAHPLQLPVAQFDAALGPPADWIV
CCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEECCCCCCCHHHHHHCCCCCCCEEE
EWKWDGIRAQLVRRAGATWLWSRGEELVTDRFPELQALGDEALPDGTVLDGEIVVWQPAR
EEEECCHHHHHHHHCCCCEEHHCCCHHHHHCCCHHHHCCCCCCCCCCEECCEEEEEECCC
ADAPAQPRPFADLQKRIGRKSLGSKLLREVPVVLLAYDLLEEHGQDLRGLPLQARRARLD
CCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ALLARTDHPALVPSPVLQGQSWAELARLRDSARALGVEGMMLKRRTAHYGVGRTRDVGIW
HHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCEE
WKWKIDPMSVDAVLIYAQRGHGRRASLYSDYTFAVWSAPQGTEGRTLVPFAKAYSGLTDA
EEEEECCCCCCEEEEEEECCCCCCCEECCCCEEEEECCCCCCCCCEECCHHHHHCCCCHH
EMARVDAIIRKTTVESFGPVRSVRPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDK
HHHHHHHHHHHHHHHHCCCCHHCCCCEEEECCHHHHHHHHHHCCCCEEECHHHHHCCCCC
PVDEADSLDTLAALLPATS
CCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQAFAALYQALDASTSSLAKQAALRDYLRGAPPEDAAWAVYFLAGGKPRQLVPTKLLRAV
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
AREAAGLPEWLFDESYEAVGDLAETIALLLPPPTQAHALGLAAWMREHLLPLRGLAPDTQ
HHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHCCCCCCHH
AERLGAQWARLAPEERLVYFKLITGAFRVGVSRLQVTQALAAVSGVDAKRIAQRLMGYTH
HHHHHHHHHHCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
VGAQPGAADYQRLVAPEGDSAGAQAAEAQGHPYPFFLAHPLQLPVAQFDAALGPPADWIV
CCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEECCCCCCCHHHHHHCCCCCCCEEE
EWKWDGIRAQLVRRAGATWLWSRGEELVTDRFPELQALGDEALPDGTVLDGEIVVWQPAR
EEEECCHHHHHHHHCCCCEEHHCCCHHHHHCCCHHHHCCCCCCCCCCEECCEEEEEECCC
ADAPAQPRPFADLQKRIGRKSLGSKLLREVPVVLLAYDLLEEHGQDLRGLPLQARRARLD
CCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ALLARTDHPALVPSPVLQGQSWAELARLRDSARALGVEGMMLKRRTAHYGVGRTRDVGIW
HHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECCEE
WKWKIDPMSVDAVLIYAQRGHGRRASLYSDYTFAVWSAPQGTEGRTLVPFAKAYSGLTDA
EEEEECCCCCCEEEEEEECCCCCCCEECCCCEEEEECCCCCCCCCEECCHHHHHCCCCHH
EMARVDAIIRKTTVESFGPVRSVRPTLVFELGFEGIARSARHKSGIAVRFPRMLRWREDK
HHHHHHHHHHHHHHHHCCCCHHCCCCEEEECCHHHHHHHHHHCCCCEEECHHHHHCCCCC
PVDEADSLDTLAALLPATS
CCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA