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The map label for this gene is atpB

Identifier: 222109517

GI number: 222109517

Start: 306448

End: 307311

Strand: Direct

Name: atpB

Synonym: Dtpsy_0297

Alternate gene names: 222109517

Gene position: 306448-307311 (Clockwise)

Preceding gene: 222109516

Following gene: 222109518

Centisome position: 8.07

GC content: 58.56

Gene sequence:

>864_bases
ATGGCCGCAGATGCGCACGCCCCGACTGCAAGTGAATACATCGTTCACCACCTGCAGCATCTCCAGAACATCAAGCAGAA
GTCCATCATCGACTTCTCGGTTGTCAACCTCGATTCCGTTGCCGTCAGCGTGATCTTGGGTGTTTTGGGTCTGTTCGTCA
TGTGGCTCGCTGCCCGCACGGCCACTTCCGGTGTGCCAGGCCGCTTCCAGGCGGCTGTCGAGATGCTGGTCGAGATGGTG
GACAACCAGGCCAAGGCCAACATCCACAACGCGCAAAGCCGTAAGTTCATTGCACCTCTGGCGCTCACCGTGTTCGTCTG
GATTTTCCTGATGAACGCTATGGACCTGCTGCCGGTGGACCTGCTGCCCGTGCTCTGGCAGGGCGCCACAGGTGACTCGC
ATGCCTACCTGCGCGTCGTGCCCACCGCCGACCTGTCCACCACCTTGGGTCTGTCCAGCGCTGTGCTGATCCTGTGCTTC
GTGTACAGCATCAAGATCAAGGGAATGGGCGGCTGGGCGCATGAACTGGTGACCGCGCCCTTCGGTACCAGCAAGAACCC
CGTTTTCGCCCTGATCCTGGGCGTGGTCAATCTGCTCATGCAGATCATTGAATACGTTGCCAAGACCGTGTCGCATGGCA
TGCGACTGTTCGGCAACATGTACGCTGGTGAGTTGGTGTTCATGCTGATTGCCCTGATGGGTGGCGCAGCGGCTATGTCG
CTCTCTGGTGTGTTGCTCCCCGTGGGGCACATCATTGCGGGCTCTATCTGGGCGATCTTCCACATCCTGATCATCACCCT
GCAGGCCTTCATTTTCATGATGCTGACGCTGATTTATCTCGGCCAGGCGCATGAAGCTCACTGA

Upstream 100 bases:

>100_bases
CTGGTCGGCATGGTGGTAACGATGAAAACGTACTGGATCGCGCTGCTGGCGCGGCCTGGTGTCCGACGAACCGATTGATA
TTTGAGAGAAGAGTTGTCCG

Downstream 100 bases:

>100_bases
TCCTTTCGTTTCCTTTCTCAACCTTCCTTTCTTTTCATCCTAGGAGTCATCATGGAAAACATTCTCGGTCTCGTCGCTCT
GGCTTGTGGTCTGATCGTGG

Product: f0f1 ATP synthase subunit a

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MAADAHAPTASEYIVHHLQHLQNIKQKSIIDFSVVNLDSVAVSVILGVLGLFVMWLAARTATSGVPGRFQAAVEMLVEMV
DNQAKANIHNAQSRKFIAPLALTVFVWIFLMNAMDLLPVDLLPVLWQGATGDSHAYLRVVPTADLSTTLGLSSAVLILCF
VYSIKIKGMGGWAHELVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGGAAAMS
LSGVLLPVGHIIAGSIWAIFHILIITLQAFIFMMLTLIYLGQAHEAH

Sequences:

>Translated_287_residues
MAADAHAPTASEYIVHHLQHLQNIKQKSIIDFSVVNLDSVAVSVILGVLGLFVMWLAARTATSGVPGRFQAAVEMLVEMV
DNQAKANIHNAQSRKFIAPLALTVFVWIFLMNAMDLLPVDLLPVLWQGATGDSHAYLRVVPTADLSTTLGLSSAVLILCF
VYSIKIKGMGGWAHELVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGGAAAMS
LSGVLLPVGHIIAGSIWAIFHILIITLQAFIFMMLTLIYLGQAHEAH
>Mature_286_residues
AADAHAPTASEYIVHHLQHLQNIKQKSIIDFSVVNLDSVAVSVILGVLGLFVMWLAARTATSGVPGRFQAAVEMLVEMVD
NQAKANIHNAQSRKFIAPLALTVFVWIFLMNAMDLLPVDLLPVLWQGATGDSHAYLRVVPTADLSTTLGLSSAVLILCFV
YSIKIKGMGGWAHELVTAPFGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGGAAAMSL
SGVLLPVGHIIAGSIWAIFHILIITLQAFIFMMLTLIYLGQAHEAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=287, Percent_Identity=47.0383275261324, Blast_Score=214, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ACIET (B9MB97)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002551781.1
- GeneID:   7383881
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0297
- ProtClustDB:   PRK05815
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 31003; Mature: 30872

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20d1b45c)-; HASH(0x20eec520)-; HASH(0x222c98c4)-; HASH(0x21111ec8)-; HASH(0x21fbd4e4)-; HASH(0x21f36304)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADAHAPTASEYIVHHLQHLQNIKQKSIIDFSVVNLDSVAVSVILGVLGLFVMWLAART
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSGVPGRFQAAVEMLVEMVDNQAKANIHNAQSRKFIAPLALTVFVWIFLMNAMDLLPVD
HCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPVLWQGATGDSHAYLRVVPTADLSTTLGLSSAVLILCFVYSIKIKGMGGWAHELVTAP
HHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
FGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGGAAAMS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LSGVLLPVGHIIAGSIWAIFHILIITLQAFIFMMLTLIYLGQAHEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
AADAHAPTASEYIVHHLQHLQNIKQKSIIDFSVVNLDSVAVSVILGVLGLFVMWLAART
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSGVPGRFQAAVEMLVEMVDNQAKANIHNAQSRKFIAPLALTVFVWIFLMNAMDLLPVD
HCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLPVLWQGATGDSHAYLRVVPTADLSTTLGLSSAVLILCFVYSIKIKGMGGWAHELVTAP
HHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
FGTSKNPVFALILGVVNLLMQIIEYVAKTVSHGMRLFGNMYAGELVFMLIALMGGAAAMS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
LSGVLLPVGHIIAGSIWAIFHILIITLQAFIFMMLTLIYLGQAHEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA