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The map label for this gene is zraR [H]

Identifier: 222109385

GI number: 222109385

Start: 182599

End: 183951

Strand: Direct

Name: zraR [H]

Synonym: Dtpsy_0164

Alternate gene names: 222109385

Gene position: 182599-183951 (Clockwise)

Preceding gene: 222109382

Following gene: 222109386

Centisome position: 4.81

GC content: 73.84

Gene sequence:

>1353_bases
ATGGCCGACACCCAAGATCTTTCCCCCACCCCGGCGCAGGTGGCGCAGACCGCGCTGCTTGCCTCCTGGCTGGAGGGGCT
GCCCGAGCCGCACATCCTGTTCGACCGCGGCTACCGCATCGTGGCCGCCAACGGCGCCTACCGTCGCCAGTTCGGCCAGG
GCGCGCCGGTGGTGGGGCGCACCTGCCATGCGGTGTCGCACCATTCGCCCGTGCCGTGCGACCAGGCGGGCGAGACCTGC
CCGCTGGCGCGCTCGCTCTTCAGCGGCCAGCGCGAGCGCGTGCTGCACCTGCACCACACCCCGGCGGGCGAGGAATACGT
GCAGATCGAACTGGTGCCGCTGCGCGACGAGGCGGGCCAGCCCCAGTACTTTCTGGAGAAGATGGAGCCGCTGCGCATTG
CCCAGGGGCAGCCGGGCGCGCCGGGCATGATCGGGCGCGCGCCCGCGTTCCAGGCCGTGCTGGAGCTGATCGCGCGCGTG
GGCCCGTCGCAGGCCAGCGTGCTGCTGCTGGGCGAGTCGGGCACGGGCAAGGAGCTGGCCGCGCGCGCCGTGCACGAGGC
CAGCCCCCGCGCGGGGCGGCCGCTGGTGGTGGTGGACTGCGCCAGCCTGCCCGAGACGCTGTTCGAGAGCGAACTGTTCG
GCCACGAGCGTGGGGCCTTCACCGGCGCCCATGCCGCACGCGCCGGCCTGGTGGAGGCGGCGCACGGCGGCACGCTGTTC
CTGGACGAGGTGGGCGACATCCCGCTCACCATGCAGGTCAAGCTGCTGCGTTTGCTGGAAAGCGGCACCTACCGCCGCGT
GGGCCACACCGAGCTGCGCCGCGCGGACATCCGCTTGGTGGCGGCCACCCACCGCGACCTGCGCGCCATGGTGCGCGAGG
GGCGGTTTCGCCAGGACCTGTACTACCGCCTGAGCACCTTTCCCATCCAGCTGCCCGCGCTGCGCGAACGCCCGCAGGAC
ATTCCGCTGCTGGCGGAATCGCTCCTGCAGCGCGTGGCCGGGGGGCGGGGCCTGGTGCTTGCGCCCGCGGCGCTGCGCCG
GCTGGCGCAGCACCCCTTCCCCGGCAACGTACGCGAGCTGCGCAACGTGCTGGAACGTGCCGCGCTGCTGACCGACGGCG
CGGCGGTGACCGCCCATACGATCGAGCGCGCGCTCTCGTTCGATGCGCCCGCGGCGGCGCCGGCCCGCGCTGCGCAGCAG
CCCGACCATGCCACCCTGCGTGACATCGAATCCGAGGCCCTGCGCGCGGCGCTGGCGGGTGGGGCCGCGTCGCGTCGCGA
ATTGGCGCGCGCCCTGGGGGTCAGCACGCGCACGCTGTACCGCAAGCTGCGACTGTTACGGGAGCAGGGCTGA

Upstream 100 bases:

>100_bases
ATGTGGAACAAAGGCTTACATCCACCCAAGGAGTCAGCGCTGCCATGGTGGACGGTAGAAACACTGCCAATGCATGCCAT
TTGTGACACCATATGTCACC

Downstream 100 bases:

>100_bases
TGCTCCTTGTTTGATAGCTGTCAGCGCTTGTTGTGATTGGCTTGCGGTCTGTTTTTGCTTGAACCAACCACCGGCCCGTG
TAGGGGCCATGTTCTGGGCG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MADTQDLSPTPAQVAQTALLASWLEGLPEPHILFDRGYRIVAANGAYRRQFGQGAPVVGRTCHAVSHHSPVPCDQAGETC
PLARSLFSGQRERVLHLHHTPAGEEYVQIELVPLRDEAGQPQYFLEKMEPLRIAQGQPGAPGMIGRAPAFQAVLELIARV
GPSQASVLLLGESGTGKELAARAVHEASPRAGRPLVVVDCASLPETLFESELFGHERGAFTGAHAARAGLVEAAHGGTLF
LDEVGDIPLTMQVKLLRLLESGTYRRVGHTELRRADIRLVAATHRDLRAMVREGRFRQDLYYRLSTFPIQLPALRERPQD
IPLLAESLLQRVAGGRGLVLAPAALRRLAQHPFPGNVRELRNVLERAALLTDGAAVTAHTIERALSFDAPAAAPARAAQQ
PDHATLRDIESEALRAALAGGAASRRELARALGVSTRTLYRKLRLLREQG

Sequences:

>Translated_450_residues
MADTQDLSPTPAQVAQTALLASWLEGLPEPHILFDRGYRIVAANGAYRRQFGQGAPVVGRTCHAVSHHSPVPCDQAGETC
PLARSLFSGQRERVLHLHHTPAGEEYVQIELVPLRDEAGQPQYFLEKMEPLRIAQGQPGAPGMIGRAPAFQAVLELIARV
GPSQASVLLLGESGTGKELAARAVHEASPRAGRPLVVVDCASLPETLFESELFGHERGAFTGAHAARAGLVEAAHGGTLF
LDEVGDIPLTMQVKLLRLLESGTYRRVGHTELRRADIRLVAATHRDLRAMVREGRFRQDLYYRLSTFPIQLPALRERPQD
IPLLAESLLQRVAGGRGLVLAPAALRRLAQHPFPGNVRELRNVLERAALLTDGAAVTAHTIERALSFDAPAAAPARAAQQ
PDHATLRDIESEALRAALAGGAASRRELARALGVSTRTLYRKLRLLREQG
>Mature_449_residues
ADTQDLSPTPAQVAQTALLASWLEGLPEPHILFDRGYRIVAANGAYRRQFGQGAPVVGRTCHAVSHHSPVPCDQAGETCP
LARSLFSGQRERVLHLHHTPAGEEYVQIELVPLRDEAGQPQYFLEKMEPLRIAQGQPGAPGMIGRAPAFQAVLELIARVG
PSQASVLLLGESGTGKELAARAVHEASPRAGRPLVVVDCASLPETLFESELFGHERGAFTGAHAARAGLVEAAHGGTLFL
DEVGDIPLTMQVKLLRLLESGTYRRVGHTELRRADIRLVAATHRDLRAMVREGRFRQDLYYRLSTFPIQLPALRERPQDI
PLLAESLLQRVAGGRGLVLAPAALRRLAQHPFPGNVRELRNVLERAALLTDGAAVTAHTIERALSFDAPAAAPARAAQQP
DHATLRDIESEALRAALAGGAASRRELARALGVSTRTLYRKLRLLREQG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=305, Percent_Identity=49.8360655737705, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1789087, Length=237, Percent_Identity=53.5864978902954, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1788550, Length=308, Percent_Identity=42.8571428571429, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082117, Length=244, Percent_Identity=49.1803278688525, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1790299, Length=351, Percent_Identity=41.8803418803419, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789233, Length=367, Percent_Identity=35.4223433242507, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87082152, Length=309, Percent_Identity=44.9838187702265, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788905, Length=248, Percent_Identity=47.9838709677419, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=38.1703470031546, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1786524, Length=247, Percent_Identity=46.9635627530364, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=46.3203463203463, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789828, Length=257, Percent_Identity=35.7976653696498, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87081858, Length=280, Percent_Identity=31.7857142857143, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48773; Mature: 48641

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTQDLSPTPAQVAQTALLASWLEGLPEPHILFDRGYRIVAANGAYRRQFGQGAPVVGR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHCCCCCCCCCH
TCHAVSHHSPVPCDQAGETCPLARSLFSGQRERVLHLHHTPAGEEYVQIELVPLRDEAGQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHEEEEECCCCCCCEEEEEEEECCCCCCC
PQYFLEKMEPLRIAQGQPGAPGMIGRAPAFQAVLELIARVGPSQASVLLLGESGTGKELA
CHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
ARAVHEASPRAGRPLVVVDCASLPETLFESELFGHERGAFTGAHAARAGLVEAAHGGTLF
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCEEE
LDEVGDIPLTMQVKLLRLLESGTYRRVGHTELRRADIRLVAATHRDLRAMVREGRFRQDL
EECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEEEHHHHHHHHHHHCCCHHHHH
YYRLSTFPIQLPALRERPQDIPLLAESLLQRVAGGRGLVLAPAALRRLAQHPFPGNVREL
HHHHHCCCEECCHHHCCCCCCHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCCHHHH
RNVLERAALLTDGAAVTAHTIERALSFDAPAAAPARAAQQPDHATLRDIESEALRAALAG
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHC
GAASRRELARALGVSTRTLYRKLRLLREQG
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADTQDLSPTPAQVAQTALLASWLEGLPEPHILFDRGYRIVAANGAYRRQFGQGAPVVGR
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCHHHHHCCCCCCCCCH
TCHAVSHHSPVPCDQAGETCPLARSLFSGQRERVLHLHHTPAGEEYVQIELVPLRDEAGQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHCCCHHHEEEEECCCCCCCEEEEEEEECCCCCCC
PQYFLEKMEPLRIAQGQPGAPGMIGRAPAFQAVLELIARVGPSQASVLLLGESGTGKELA
CHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
ARAVHEASPRAGRPLVVVDCASLPETLFESELFGHERGAFTGAHAARAGLVEAAHGGTLF
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCEEE
LDEVGDIPLTMQVKLLRLLESGTYRRVGHTELRRADIRLVAATHRDLRAMVREGRFRQDL
EECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEEEHHHHHHHHHHHCCCHHHHH
YYRLSTFPIQLPALRERPQDIPLLAESLLQRVAGGRGLVLAPAALRRLAQHPFPGNVREL
HHHHHCCCEECCHHHCCCCCCHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCCHHHH
RNVLERAALLTDGAAVTAHTIERALSFDAPAAAPARAAQQPDHATLRDIESEALRAALAG
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHC
GAASRRELARALGVSTRTLYRKLRLLREQG
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]