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The map label for this gene is mccB [H]

Identifier: 222102933

GI number: 222102933

Start: 620258

End: 621793

Strand: Direct

Name: mccB [H]

Synonym: Avi_7689

Alternate gene names: 222102933

Gene position: 620258-621793 (Clockwise)

Preceding gene: 222102925

Following gene: 222102934

Centisome position: 98.18

GC content: 59.83

Gene sequence:

>1536_bases
ATGGCGGAGGCTGTCGCCGATCTCGCCTTGAAAACGGCTCAGGCGGCACTGGGTGGTGGCGAGGTGGCGCGCAGGCGCCA
CACCGGGCGCGGAAAGCTGCTGCCTCGTGAGCGGATCGATCGCTTGCTCGATCCCGGATCGCCATTTCTGGAGATTGGTC
AGCTTGCGGCCCACGGCCTTTATGATGGCGAAGCCCCGTCTGCGGGTATCGTCGCAGGCATTGGCAATGTCGAAGGCCGC
CGCTGCATGGTGGTTGCCAATGACGCGACGGTAAAGGGCGGCACCTACTATCCGATGACGGTGAAGAAGCACCTGCGCGC
CCAGAAAATTGCTGCGGAAAACCGTCTGCCCTGTCTTTATCTCGTGGATTCGGGCGGTGGCTATCTGCCGCTCCAGGATG
AGTTTTTCCCCGACGAAAATCATTTTGGCCGCATCTTCTACAATCAGGCGCAGATGTCGGCGGCTGGTATTGCGCAGATC
GCCGTTGTCATGGGCTCCTGCACAGCGGGTGGAGCTTATGTGCCCGCCATGAGCGATGAGACGGTGATTGTGCGCGAACA
GGGCACAATCTTTCTCGCAGGCCCGCCATTGGTGAAGGCGGCAACCGGTGAGATTGTCACGGCGGAAGATCTTGGCGGTG
GCGATGTGCACACCCGCATCTCCGGCGTTGCCGACCATTTGGCCGAAAATGATTCCCACGCCCTTCACATCGCCCGGCGG
ATCGTCTCGACATTGCCCGCGCAGGAAGACGCGGCCAGCCAGTTTGACGAGCCGATTTATCCAGCCGAAGAGCTTTACGG
CATCATCCCATCTGACACGCGAAAGCCTTATGATGTGCGTGAGGTGATTGCGCGTCTGGTGGACGGCTCGCGGTTTGACG
AATTCAAGGCGCGCTACGGCACAACGCTTGTGACGGGCTTTGCCCATCTTTATGGCATGCAGGTCGGCATCATTGCCAAC
AATGGCATATTGTTTGGGGATGCGGCGCTGAAGGGGGCGCATTTTATTGAGCTTTGCGTTCAGCGCCGTATTCCGCTGCT
GTTTTTGCAAAACATTACCGGCTTTATGGTTGGGCGCGCTTATGAAAATGAGGGCATTGCCAAGCACGGCGCAAAACTGG
TGACGGCGGTGGCCACAGCCGCTGTTCCAAAACTCACACTCGTCATCGGCGGCAGCTTTGGCGCCGGAAATTACGGCATG
TGCGGGCGCGCCTACAGCCCCCGCTTCCTGTGGATGTGGCCCAATGCGCGGATCAGCGTCATGGGTGGAGATCAGGCGGC
GTCCGTTCTGGCCACACTTCGACGTGACGGCGTTGCCGCCAAAGGCGAAACATGGCCGCAGCAAGAGGAAGATGCATTCA
AAAACGGCATCCGCGCCCAATACGAACGGCAGGGCCACCCCTATTATTCGACCGCCCGTTTGTGGGATGACGGCATCATT
GACCCCGCGCAAACCCGCCGGGTTCTCGGCCTTTCCCTGTCAACGGCGCTCAATGCGCCCATCGGTGAAACCCGCTTCGG
CCTTTTCCGCATGTGA

Upstream 100 bases:

>100_bases
GGCGCGGCGGAAACGCTTGCGGCAGAGGAGGCCGGGCGTGAATCCATTGTCAACAAGCATCAATTCCGGCTCGGCAGAAT
TTCGCGCCAATGCCGAGGCG

Downstream 100 bases:

>100_bases
GATTGCCATGATCTATAAAACCCTTGATCTCGAATTGAACGGTGCGGTCGCAACAGTGTGGATGAACCGGCCAGACCTGC
ACAATGCCTTCGATGAGATG

Product: 3-methylcrotonoyl-CoA carboxylase beta subunit

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MAEAVADLALKTAQAALGGGEVARRRHTGRGKLLPRERIDRLLDPGSPFLEIGQLAAHGLYDGEAPSAGIVAGIGNVEGR
RCMVVANDATVKGGTYYPMTVKKHLRAQKIAAENRLPCLYLVDSGGGYLPLQDEFFPDENHFGRIFYNQAQMSAAGIAQI
AVVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEIVTAEDLGGGDVHTRISGVADHLAENDSHALHIARR
IVSTLPAQEDAASQFDEPIYPAEELYGIIPSDTRKPYDVREVIARLVDGSRFDEFKARYGTTLVTGFAHLYGMQVGIIAN
NGILFGDAALKGAHFIELCVQRRIPLLFLQNITGFMVGRAYENEGIAKHGAKLVTAVATAAVPKLTLVIGGSFGAGNYGM
CGRAYSPRFLWMWPNARISVMGGDQAASVLATLRRDGVAAKGETWPQQEEDAFKNGIRAQYERQGHPYYSTARLWDDGII
DPAQTRRVLGLSLSTALNAPIGETRFGLFRM

Sequences:

>Translated_511_residues
MAEAVADLALKTAQAALGGGEVARRRHTGRGKLLPRERIDRLLDPGSPFLEIGQLAAHGLYDGEAPSAGIVAGIGNVEGR
RCMVVANDATVKGGTYYPMTVKKHLRAQKIAAENRLPCLYLVDSGGGYLPLQDEFFPDENHFGRIFYNQAQMSAAGIAQI
AVVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEIVTAEDLGGGDVHTRISGVADHLAENDSHALHIARR
IVSTLPAQEDAASQFDEPIYPAEELYGIIPSDTRKPYDVREVIARLVDGSRFDEFKARYGTTLVTGFAHLYGMQVGIIAN
NGILFGDAALKGAHFIELCVQRRIPLLFLQNITGFMVGRAYENEGIAKHGAKLVTAVATAAVPKLTLVIGGSFGAGNYGM
CGRAYSPRFLWMWPNARISVMGGDQAASVLATLRRDGVAAKGETWPQQEEDAFKNGIRAQYERQGHPYYSTARLWDDGII
DPAQTRRVLGLSLSTALNAPIGETRFGLFRM
>Mature_510_residues
AEAVADLALKTAQAALGGGEVARRRHTGRGKLLPRERIDRLLDPGSPFLEIGQLAAHGLYDGEAPSAGIVAGIGNVEGRR
CMVVANDATVKGGTYYPMTVKKHLRAQKIAAENRLPCLYLVDSGGGYLPLQDEFFPDENHFGRIFYNQAQMSAAGIAQIA
VVMGSCTAGGAYVPAMSDETVIVREQGTIFLAGPPLVKAATGEIVTAEDLGGGDVHTRISGVADHLAENDSHALHIARRI
VSTLPAQEDAASQFDEPIYPAEELYGIIPSDTRKPYDVREVIARLVDGSRFDEFKARYGTTLVTGFAHLYGMQVGIIANN
GILFGDAALKGAHFIELCVQRRIPLLFLQNITGFMVGRAYENEGIAKHGAKLVTAVATAAVPKLTLVIGGSFGAGNYGMC
GRAYSPRFLWMWPNARISVMGGDQAASVLATLRRDGVAAKGETWPQQEEDAFKNGIRAQYERQGHPYYSTARLWDDGIID
PAQTRRVLGLSLSTALNAPIGETRFGLFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=515, Percent_Identity=66.2135922330097, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=492, Percent_Identity=32.7235772357724, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI295821216, Length=512, Percent_Identity=31.640625, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI310133460, Length=125, Percent_Identity=61.6, Blast_Score=143, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17552936, Length=515, Percent_Identity=62.5242718446602, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=494, Percent_Identity=35.0202429149798, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25147359, Length=494, Percent_Identity=35.0202429149798, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586065, Length=531, Percent_Identity=64.5951035781544, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 54946; Mature: 54815

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAVADLALKTAQAALGGGEVARRRHTGRGKLLPRERIDRLLDPGSPFLEIGQLAAHGL
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCC
YDGEAPSAGIVAGIGNVEGRRCMVVANDATVKGGTYYPMTVKKHLRAQKIAAENRLPCLY
CCCCCCCCCEEEECCCCCCCEEEEEECCCEECCCEECCHHHHHHHHHHHHHHCCCCCEEE
LVDSGGGYLPLQDEFFPDENHFGRIFYNQAQMSAAGIAQIAVVMGSCTAGGAYVPAMSDE
EEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCC
TVIVREQGTIFLAGPPLVKAATGEIVTAEDLGGGDVHTRISGVADHLAENDSHALHIARR
EEEEEECCEEEEECCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
IVSTLPAQEDAASQFDEPIYPAEELYGIIPSDTRKPYDVREVIARLVDGSRFDEFKARYG
HHHHCCCCHHHHHHCCCCCCCHHHHEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHC
TTLVTGFAHLYGMQVGIIANNGILFGDAALKGAHFIELCVQRRIPLLFLQNITGFMVGRA
HHHHHHHHHHHCCEEEEEECCCEEEECHHHCCHHHHHHHHHHCCCEEEHHHHHHHHEECE
YENEGIAKHGAKLVTAVATAAVPKLTLVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISV
ECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEE
MGGDQAASVLATLRRDGVAAKGETWPQQEEDAFKNGIRAQYERQGHPYYSTARLWDDGII
ECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCEEEHEECCCCCC
DPAQTRRVLGLSLSTALNAPIGETRFGLFRM
CHHHHHHHHEEEHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEAVADLALKTAQAALGGGEVARRRHTGRGKLLPRERIDRLLDPGSPFLEIGQLAAHGL
CHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCC
YDGEAPSAGIVAGIGNVEGRRCMVVANDATVKGGTYYPMTVKKHLRAQKIAAENRLPCLY
CCCCCCCCCEEEECCCCCCCEEEEEECCCEECCCEECCHHHHHHHHHHHHHHCCCCCEEE
LVDSGGGYLPLQDEFFPDENHFGRIFYNQAQMSAAGIAQIAVVMGSCTAGGAYVPAMSDE
EEECCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCC
TVIVREQGTIFLAGPPLVKAATGEIVTAEDLGGGDVHTRISGVADHLAENDSHALHIARR
EEEEEECCEEEEECCCEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
IVSTLPAQEDAASQFDEPIYPAEELYGIIPSDTRKPYDVREVIARLVDGSRFDEFKARYG
HHHHCCCCHHHHHHCCCCCCCHHHHEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHC
TTLVTGFAHLYGMQVGIIANNGILFGDAALKGAHFIELCVQRRIPLLFLQNITGFMVGRA
HHHHHHHHHHHCCEEEEEECCCEEEECHHHCCHHHHHHHHHHCCCEEEHHHHHHHHEECE
YENEGIAKHGAKLVTAVATAAVPKLTLVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISV
ECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEE
MGGDQAASVLATLRRDGVAAKGETWPQQEEDAFKNGIRAQYERQGHPYYSTARLWDDGII
ECCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCEEEHEECCCCCC
DPAQTRRVLGLSLSTALNAPIGETRFGLFRM
CHHHHHHHHEEEHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]