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The map label for this gene is fadD26 [H]

Identifier: 222102649

GI number: 222102649

Start: 276366

End: 278633

Strand: Direct

Name: fadD26 [H]

Synonym: Avi_7308

Alternate gene names: 222102649

Gene position: 276366-278633 (Clockwise)

Preceding gene: 222102631

Following gene: 222102650

Centisome position: 43.74

GC content: 61.29

Gene sequence:

>2268_bases
ATGGCAGTGAACGATACGTCCTGGACGCAACGAACCTCGGAAAGTTCAGTGGATTTTATATCTATAATTCATATGCTTGA
GCATCGTGCTCGGGATATGGAGGATGATGTGGCCATGCGCTTCTTTCATGATGACGCGGTCGCTGCGGCGCAGGCGAGGC
CGGATTCCTGGACCTGGCGCATGCTTCGCGATCGGGCGCGGCGTGTTGGTCAAGAGATTGCGCAGACAGGACTTGTCATC
CCCGGCGCACGTATTCTCGTGGTCTATCCGCCGGGCCTTAGCTTCATCGCCGCTTTCCTTGGATGCCTTTACGCAGGCAC
TGTTCCCGTGCCCGTTCCGGCCCCGCGGCGTGCTGATGGAATCAATCGCTGGCTGCATATCGCGCAGGATGCCGGGATCT
CCGGAATTCTCTGTGCCGACGACCTTCTGGACGGGCTTCGCCCCCTTCAACGGGCAGTCGGACATGGCTTTGCGCTCGCC
CCTAAAGCAGCCGATCCGGCGCGCCCGGTCGTCTTTGAAGATGACGGCAGGCCATTCCATGCGCCGGAGGCAAAGCATGT
CGCTTTCTTGCAATATACGTCGGGTTCGACGAGCGATCCGAAGGGGGTCATGGTCACGCATGGCAACCTGATGGCCAATC
TGCGGCAGATCAGCACTGCCTTCGAATACGACCCATCCGACATATCCGCCTGCTGGCTGCCGCACTATCACGATATGGGG
CTGATCGACGGCATCCTGTCGCCGGTGTTCAACGGCTTTCCAGTGGCGCTGATGGCGCCTGCCTCGTTCCTGCGCAGGCC
TCTGCGCTTTCTGGAGCTGGCAAGCCATGTTCGCGCCACCGTCATTGGCGGCCCGAATTTTTCCTACGAGCACTGCGTCG
ATAAATATGCGCCGGAGGCGGCCGCCGGACTTGATCTCTCCAACGTCCGAATCGCCTATAACGGGGCCGAACCGATCCGC
CCGAAGACGCTAGAGCGCTTCACCGCCGCCTTTGCGCCCCACGGTTTCCATAGTAGGGCCTTTTATTGTTGCTACGGGCA
GGCAGAAGCCACGCTGTTCCAGACGGGTAACAGTCCCGACGATCCACCGCTGATCCTGTCCGTCAGCCGCAAGGCGCTTG
TCGAAACCGGGGCTGCGGTCGAAGCGGATGATGGCGACGAGCATGATAAGCTCGCCCTTGCCGCCTGCGGTCGCCCTGCC
GAGGGGCTTGACCTTGCGCTTGTCGATCCCGAGGCGGGCCTGCGTGTGGATGATGGCACGGTCGGCGAGATCTGGATTCG
GGGTCCGAACGTGACCCCCGGCTATTGGGGCCGCGCTAAACTGAACGCAGAGACCTTTGATCAGGTGCTGGATGGATCGC
GTGGTTGGCGCCGGACCGGTGATCTGGGCTTTCGCCGCAATGGGCAGCTCTACATCACTGGTCGGCTGAAAGACCTGGTG
ATCATCCGCGGGCAGAACCATCACCCGGAAGATATTGAGCAATCCGTTTTCTCCAGCCATCCGGCGCTTGCACAAGGCCG
GGCAGGGGTCTTTGCCATCGAGGTCGATGGCGAGGAGCAATTGGGCGTGGTCTGTGAGCTGACCCGCGAGGGCCTGCGCG
ATCTTGATGGTGATGACGTCATCCGTGCCGTGCGCGGTGCCGTCTCGCGCAATCACAATGTCAGGGCCGCCGTCATTGCG
CTGCTGCGGCCGAGCAGTCTGCCACGCACGCCGAGTGGAAAAGTCCGCCGCTTCGCTTGCCGACAGGGGATCGTGACGGG
GGATCTGCGCATCGTTGCCCGCTGGGATGCAAAGCCGCAGAGCGTGCTCAATGCCCCGGCAATTGCCGAGCAACGAAGCT
GGCGTGACCAGCTTCTGGAGGTGCCCAAAGCTCTTCGCAAGGAAGCACTGCGGCATCTGCTGCGGCAGGAAGTGGCTATG
CTTGCCCGGCTGGGCGAAGGGGATTTGCCCGGAAATTCCGCTGGTTTCTTCGATCTTGGTCTCGACTCTGTGGCGCTCGT
CAATATCGGCGCTACGGTTGAGCGGGAACTCGGCGTGCCGGTCCGGCCAACACTGATTTTCGAACATCCCACCATCCTGG
CCCTTTCGGACCATCTCTACGGCCTCATCGAAGACGATCAATCGGAGACCGTGCCTCTTCAGGACGTAAAGCTCCAGAGC
AATGGGCCTGTGGCTCAGACCCCGCCCGCGTTAGCATCTGGGTCTGCCTCTGTCGCCAGCTCCGCTATTACCTCGGAACT
TGCTGCCCTGAAGGCATTGCTTCGCTGA

Upstream 100 bases:

>100_bases
ATCACCGAAATTTCAAGCGGCTGAGTGTCCTTTTTGAAAGAGACAAGAGCATGGGTCGGCGACGGGCGGATTTTCCGCGG
CGCTCTTCAGCAAGGGGTGG

Downstream 100 bases:

>100_bases
GCACAGCATCCGCAATTTGAACGAGAGAAACCCTATGACTGACGTTGAAACCCCGACCCCGGACATGGTTGACCAGGATG
AGATCCTCTCGATTTTAAAA

Product: polyketide synthetase

Products: AMP; diphosphate +an acyl-CoA [C]

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MAVNDTSWTQRTSESSVDFISIIHMLEHRARDMEDDVAMRFFHDDAVAAAQARPDSWTWRMLRDRARRVGQEIAQTGLVI
PGARILVVYPPGLSFIAAFLGCLYAGTVPVPVPAPRRADGINRWLHIAQDAGISGILCADDLLDGLRPLQRAVGHGFALA
PKAADPARPVVFEDDGRPFHAPEAKHVAFLQYTSGSTSDPKGVMVTHGNLMANLRQISTAFEYDPSDISACWLPHYHDMG
LIDGILSPVFNGFPVALMAPASFLRRPLRFLELASHVRATVIGGPNFSYEHCVDKYAPEAAAGLDLSNVRIAYNGAEPIR
PKTLERFTAAFAPHGFHSRAFYCCYGQAEATLFQTGNSPDDPPLILSVSRKALVETGAAVEADDGDEHDKLALAACGRPA
EGLDLALVDPEAGLRVDDGTVGEIWIRGPNVTPGYWGRAKLNAETFDQVLDGSRGWRRTGDLGFRRNGQLYITGRLKDLV
IIRGQNHHPEDIEQSVFSSHPALAQGRAGVFAIEVDGEEQLGVVCELTREGLRDLDGDDVIRAVRGAVSRNHNVRAAVIA
LLRPSSLPRTPSGKVRRFACRQGIVTGDLRIVARWDAKPQSVLNAPAIAEQRSWRDQLLEVPKALRKEALRHLLRQEVAM
LARLGEGDLPGNSAGFFDLGLDSVALVNIGATVERELGVPVRPTLIFEHPTILALSDHLYGLIEDDQSETVPLQDVKLQS
NGPVAQTPPALASGSASVASSAITSELAALKALLR

Sequences:

>Translated_755_residues
MAVNDTSWTQRTSESSVDFISIIHMLEHRARDMEDDVAMRFFHDDAVAAAQARPDSWTWRMLRDRARRVGQEIAQTGLVI
PGARILVVYPPGLSFIAAFLGCLYAGTVPVPVPAPRRADGINRWLHIAQDAGISGILCADDLLDGLRPLQRAVGHGFALA
PKAADPARPVVFEDDGRPFHAPEAKHVAFLQYTSGSTSDPKGVMVTHGNLMANLRQISTAFEYDPSDISACWLPHYHDMG
LIDGILSPVFNGFPVALMAPASFLRRPLRFLELASHVRATVIGGPNFSYEHCVDKYAPEAAAGLDLSNVRIAYNGAEPIR
PKTLERFTAAFAPHGFHSRAFYCCYGQAEATLFQTGNSPDDPPLILSVSRKALVETGAAVEADDGDEHDKLALAACGRPA
EGLDLALVDPEAGLRVDDGTVGEIWIRGPNVTPGYWGRAKLNAETFDQVLDGSRGWRRTGDLGFRRNGQLYITGRLKDLV
IIRGQNHHPEDIEQSVFSSHPALAQGRAGVFAIEVDGEEQLGVVCELTREGLRDLDGDDVIRAVRGAVSRNHNVRAAVIA
LLRPSSLPRTPSGKVRRFACRQGIVTGDLRIVARWDAKPQSVLNAPAIAEQRSWRDQLLEVPKALRKEALRHLLRQEVAM
LARLGEGDLPGNSAGFFDLGLDSVALVNIGATVERELGVPVRPTLIFEHPTILALSDHLYGLIEDDQSETVPLQDVKLQS
NGPVAQTPPALASGSASVASSAITSELAALKALLR
>Mature_754_residues
AVNDTSWTQRTSESSVDFISIIHMLEHRARDMEDDVAMRFFHDDAVAAAQARPDSWTWRMLRDRARRVGQEIAQTGLVIP
GARILVVYPPGLSFIAAFLGCLYAGTVPVPVPAPRRADGINRWLHIAQDAGISGILCADDLLDGLRPLQRAVGHGFALAP
KAADPARPVVFEDDGRPFHAPEAKHVAFLQYTSGSTSDPKGVMVTHGNLMANLRQISTAFEYDPSDISACWLPHYHDMGL
IDGILSPVFNGFPVALMAPASFLRRPLRFLELASHVRATVIGGPNFSYEHCVDKYAPEAAAGLDLSNVRIAYNGAEPIRP
KTLERFTAAFAPHGFHSRAFYCCYGQAEATLFQTGNSPDDPPLILSVSRKALVETGAAVEADDGDEHDKLALAACGRPAE
GLDLALVDPEAGLRVDDGTVGEIWIRGPNVTPGYWGRAKLNAETFDQVLDGSRGWRRTGDLGFRRNGQLYITGRLKDLVI
IRGQNHHPEDIEQSVFSSHPALAQGRAGVFAIEVDGEEQLGVVCELTREGLRDLDGDDVIRAVRGAVSRNHNVRAAVIAL
LRPSSLPRTPSGKVRRFACRQGIVTGDLRIVARWDAKPQSVLNAPAIAEQRSWRDQLLEVPKALRKEALRHLLRQEVAML
ARLGEGDLPGNSAGFFDLGLDSVALVNIGATVERELGVPVRPTLIFEHPTILALSDHLYGLIEDDQSETVPLQDVKLQSN
GPVAQTPPALASGSASVASSAITSELAALKALLR

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI44888818, Length=613, Percent_Identity=25.9380097879282, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI45827692, Length=611, Percent_Identity=25.69558101473, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI225735629, Length=611, Percent_Identity=25.69558101473, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI55749758, Length=549, Percent_Identity=26.2295081967213, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI225735625, Length=544, Percent_Identity=24.0808823529412, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI45827694, Length=481, Percent_Identity=24.1164241164241, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI225735627, Length=454, Percent_Identity=24.0088105726872, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI45827696, Length=454, Percent_Identity=24.0088105726872, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI156151445, Length=403, Percent_Identity=25.0620347394541, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI45827698, Length=416, Percent_Identity=24.2788461538462, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI187761345, Length=469, Percent_Identity=23.6673773987207, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI187761343, Length=469, Percent_Identity=23.6673773987207, Blast_Score=83, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202679, Length=604, Percent_Identity=24.6688741721854, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531443, Length=573, Percent_Identity=22.6876090750436, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24654656, Length=620, Percent_Identity=23.2258064516129, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859661, Length=555, Percent_Identity=26.1261261261261, Blast_Score=113, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.3 [C]

Molecular weight: Translated: 81900; Mature: 81769

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNDTSWTQRTSESSVDFISIIHMLEHRARDMEDDVAMRFFHDDAVAAAQARPDSWTWR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHCCCCCHHHH
MLRDRARRVGQEIAQTGLVIPGARILVVYPPGLSFIAAFLGCLYAGTVPVPVPAPRRADG
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
INRWLHIAQDAGISGILCADDLLDGLRPLQRAVGHGFALAPKAADPARPVVFEDDGRPFH
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEECCCCCCCC
APEAKHVAFLQYTSGSTSDPKGVMVTHGNLMANLRQISTAFEYDPSDISACWLPHYHDMG
CCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCH
LIDGILSPVFNGFPVALMAPASFLRRPLRFLELASHVRATVIGGPNFSYEHCVDKYAPEA
HHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCHH
AAGLDLSNVRIAYNGAEPIRPKTLERFTAAFAPHGFHSRAFYCCYGQAEATLFQTGNSPD
HCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCC
DPPLILSVSRKALVETGAAVEADDGDEHDKLALAACGRPAEGLDLALVDPEAGLRVDDGT
CCCEEEEECHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCEECCCC
VGEIWIRGPNVTPGYWGRAKLNAETFDQVLDGSRGWRRTGDLGFRRNGQLYITGRLKDLV
EEEEEEECCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEE
IIRGQNHHPEDIEQSVFSSHPALAQGRAGVFAIEVDGEEQLGVVCELTREGLRDLDGDDV
EEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHH
IRAVRGAVSRNHNVRAAVIALLRPSSLPRTPSGKVRRFACRQGIVTGDLRIVARWDAKPQ
HHHHHHHHHCCCCHHHHHHEEECCCCCCCCCCHHHHHHHHHCCCEECCEEEEEEECCCHH
SVLNAPAIAEQRSWRDQLLEVPKALRKEALRHLLRQEVAMLARLGEGDLPGNSAGFFDLG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
LDSVALVNIGATVERELGVPVRPTLIFEHPTILALSDHLYGLIEDDQSETVPLQDVKLQS
CCCEEEEECCCHHHHHCCCCCCCEEEECCCEEEEECCCCEEEEECCCCCCCCHHHEEECC
NGPVAQTPPALASGSASVASSAITSELAALKALLR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
AVNDTSWTQRTSESSVDFISIIHMLEHRARDMEDDVAMRFFHDDAVAAAQARPDSWTWR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHCCCCCHHHH
MLRDRARRVGQEIAQTGLVIPGARILVVYPPGLSFIAAFLGCLYAGTVPVPVPAPRRADG
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
INRWLHIAQDAGISGILCADDLLDGLRPLQRAVGHGFALAPKAADPARPVVFEDDGRPFH
HHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEECCCCCCCC
APEAKHVAFLQYTSGSTSDPKGVMVTHGNLMANLRQISTAFEYDPSDISACWLPHYHDMG
CCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCH
LIDGILSPVFNGFPVALMAPASFLRRPLRFLELASHVRATVIGGPNFSYEHCVDKYAPEA
HHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCHH
AAGLDLSNVRIAYNGAEPIRPKTLERFTAAFAPHGFHSRAFYCCYGQAEATLFQTGNSPD
HCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCC
DPPLILSVSRKALVETGAAVEADDGDEHDKLALAACGRPAEGLDLALVDPEAGLRVDDGT
CCCEEEEECHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCEECCCC
VGEIWIRGPNVTPGYWGRAKLNAETFDQVLDGSRGWRRTGDLGFRRNGQLYITGRLKDLV
EEEEEEECCCCCCCCCCCEEECHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCEEEE
IIRGQNHHPEDIEQSVFSSHPALAQGRAGVFAIEVDGEEQLGVVCELTREGLRDLDGDDV
EEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHH
IRAVRGAVSRNHNVRAAVIALLRPSSLPRTPSGKVRRFACRQGIVTGDLRIVARWDAKPQ
HHHHHHHHHCCCCHHHHHHEEECCCCCCCCCCHHHHHHHHHCCCEECCEEEEEEECCCHH
SVLNAPAIAEQRSWRDQLLEVPKALRKEALRHLLRQEVAMLARLGEGDLPGNSAGFFDLG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECC
LDSVALVNIGATVERELGVPVRPTLIFEHPTILALSDHLYGLIEDDQSETVPLQDVKLQS
CCCEEEEECCCHHHHHCCCCCCCEEEECCCEEEEECCCCEEEEECCCCCCCCHHHEEECC
NGPVAQTPPALASGSASVASSAITSELAALKALLR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Salts [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.0408 {octanoate}} 0.0125 {octanoate}} 0.0059 {octanoate}} 0.00072 {octanoate}} 0.0013 {undecanoate}} 0.0022 {pentadecanoate}} 0.053 {CoA}} 0.035 {CoA}} 0.034 {CoA}} 0.0034 {tridecanoate}} 0.002 {laurate}} 0.0019 {laurate}} 0.0

Substrates: ATP; a long-chain carboxylic acid; CoA [C]

Specific reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate +an acyl-CoA [C]

General reaction: Acid-thiol ligation; Phosphorylation [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]