Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 222102597

GI number: 222102597

Start: 203401

End: 204996

Strand: Direct

Name: ggt [H]

Synonym: Avi_7242

Alternate gene names: 222102597

Gene position: 203401-204996 (Clockwise)

Preceding gene: 222102596

Following gene: 222102610

Centisome position: 32.2

GC content: 59.34

Gene sequence:

>1596_bases
ATGCGCAATTTCGAAAAGCCAACGCGCTCAGTGGCGGTGTCGACTGACGCCATGGCAGCAACGTCTCACCCTTATGCAAC
GCTCGCTGCCATCAATATCCTGCAAGCAGGCGGTAATGCCATGGACGCTGCCATTGCTGCCTGTGCTGTGCAATGCGTTG
TGGAGCCGGGTTCCACCGGCATCGGTGGCGATTGTTTCGCGCTCTACGCGCCAAAGGGTGGTGATCAGGTCATTGCCTAT
AACGGTTCGGGCCGCACGCCCGCTGCCCTGACGGTGGACTGGTTTGAAGAGCGAGGGCTTGCCGAAGTGCCGCGCCAATC
GCCGTCTGCCGTTACCATACCCGGCGCAATCGACGCGTGGACGCGGCTGCACGCCGACCATGGCCGCCTTCCGTTTGAGC
AGATCCTGCAACCTGCGATCCGCTATGCCGAGAACGGTTACGCCATCACACCAAGGGTGTATCGTGATTGGGTACGGGAA
GAGAAGCTGCTCAACGATGACCCGGCCGCGTCGGAGATCTTTCTTCCCAACGGCCGTGCGCCGCAAATCGGCGAAGTCCA
CCATCAACCTCGATTGGCGGCAACCCTGCGCCGGATCGCCGCTGAAGGCCGAGATGGCTTTTACAAGGGGGCGGTTGCGG
AAGACATGGTTGATCGGCTTCGCGCCCTCGGCGGCCTTCATACCCTTGAGGATTTTGCTGAGGCCAAGGGAGAGTATGTG
GTGCCGGTCACCACGACATTTCGCGACCATACAATCCATGAATGCCCCCCAAACGGGCAGGGCATTATCGCTCTGCTCAT
TCTCAATATTCTCTCGCGGTTCGACACCCAGGACGATCCAAGTTCAGCAGACCGCCTACATCTGGAGATTGAGGCCACGC
GCCTTGCCTATGCCGCCCGCGACGCCTGGCTCGCGGATCCAGAGAAGGCCAGCGTTCCCGTTGAAGACATGCTCTCCGAG
GAATTCGCCACACACCTCGCCGGCATGATCGATCTCACCCGCGCGCTGACCAATCTGCCGGACTTTGAGATGCCTCTCCA
TCGCGACACGGTCTATATTTCGGTGATCGACTCTGAGCGCAACGCTGTCAGTTTCATCAACTCCATCTTCGACTGCTTCG
GCTCAGGCATTGTCGCCCCGCAATCTGGTGTCGTCCTGCACAATCGCGGTCAGAGCTTCTCCCTGAAGCGTGACCATCCG
AACATGATCGCACCGGGAAAGCGTCCGCTGCACACGATCATTCCGGGCATGGTGACACGGGCAGGCCGTACGGAAATATC
CTTTGGGGTCATGGGCGGCTATTATCAGGCCATGGGCCATGCGCATCTGATTTCCAAGGTTATCGACTATGGCATGGACC
TTCAGGACGCCATCGATTTGCCACGCCTCATTCCCGTCGGCGGCAAGGTGCCGCGTGTCGAGGCCGAGCATACAGTACCT
GCAGAGACCATTGCCCTGTTGAGACGTCGCGGCTTCGAGATCGTGCCAGCGGAAGATCCGATCGGTGGCGCTCAGATTAT
CAGGATTGATTGGGAAAATGGTACGCTGACAGGTGCCTCCGAATCCCGCAAGGACGGGATTGCTCTCGGCTATTGA

Upstream 100 bases:

>100_bases
TCGTGCGGGCGCTCACCACGCTCGAAGCCAGACTGACACTGTATCGGACCCGCAGCTGACGCGATTTATTCGAATTTTCA
GACGAGGAGACTTAAAAGAC

Downstream 100 bases:

>100_bases
AGATCACAGTCTCTGACCGGAACAGGTAAAACAGTATACACCGCCCTTGGCTGCCTTCCTATGTCACAAGGACATCAGCC
AGGAAGCGGCCGGCCTGAGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MRNFEKPTRSVAVSTDAMAATSHPYATLAAINILQAGGNAMDAAIAACAVQCVVEPGSTGIGGDCFALYAPKGGDQVIAY
NGSGRTPAALTVDWFEERGLAEVPRQSPSAVTIPGAIDAWTRLHADHGRLPFEQILQPAIRYAENGYAITPRVYRDWVRE
EKLLNDDPAASEIFLPNGRAPQIGEVHHQPRLAATLRRIAAEGRDGFYKGAVAEDMVDRLRALGGLHTLEDFAEAKGEYV
VPVTTTFRDHTIHECPPNGQGIIALLILNILSRFDTQDDPSSADRLHLEIEATRLAYAARDAWLADPEKASVPVEDMLSE
EFATHLAGMIDLTRALTNLPDFEMPLHRDTVYISVIDSERNAVSFINSIFDCFGSGIVAPQSGVVLHNRGQSFSLKRDHP
NMIAPGKRPLHTIIPGMVTRAGRTEISFGVMGGYYQAMGHAHLISKVIDYGMDLQDAIDLPRLIPVGGKVPRVEAEHTVP
AETIALLRRRGFEIVPAEDPIGGAQIIRIDWENGTLTGASESRKDGIALGY

Sequences:

>Translated_531_residues
MRNFEKPTRSVAVSTDAMAATSHPYATLAAINILQAGGNAMDAAIAACAVQCVVEPGSTGIGGDCFALYAPKGGDQVIAY
NGSGRTPAALTVDWFEERGLAEVPRQSPSAVTIPGAIDAWTRLHADHGRLPFEQILQPAIRYAENGYAITPRVYRDWVRE
EKLLNDDPAASEIFLPNGRAPQIGEVHHQPRLAATLRRIAAEGRDGFYKGAVAEDMVDRLRALGGLHTLEDFAEAKGEYV
VPVTTTFRDHTIHECPPNGQGIIALLILNILSRFDTQDDPSSADRLHLEIEATRLAYAARDAWLADPEKASVPVEDMLSE
EFATHLAGMIDLTRALTNLPDFEMPLHRDTVYISVIDSERNAVSFINSIFDCFGSGIVAPQSGVVLHNRGQSFSLKRDHP
NMIAPGKRPLHTIIPGMVTRAGRTEISFGVMGGYYQAMGHAHLISKVIDYGMDLQDAIDLPRLIPVGGKVPRVEAEHTVP
AETIALLRRRGFEIVPAEDPIGGAQIIRIDWENGTLTGASESRKDGIALGY
>Mature_531_residues
MRNFEKPTRSVAVSTDAMAATSHPYATLAAINILQAGGNAMDAAIAACAVQCVVEPGSTGIGGDCFALYAPKGGDQVIAY
NGSGRTPAALTVDWFEERGLAEVPRQSPSAVTIPGAIDAWTRLHADHGRLPFEQILQPAIRYAENGYAITPRVYRDWVRE
EKLLNDDPAASEIFLPNGRAPQIGEVHHQPRLAATLRRIAAEGRDGFYKGAVAEDMVDRLRALGGLHTLEDFAEAKGEYV
VPVTTTFRDHTIHECPPNGQGIIALLILNILSRFDTQDDPSSADRLHLEIEATRLAYAARDAWLADPEKASVPVEDMLSE
EFATHLAGMIDLTRALTNLPDFEMPLHRDTVYISVIDSERNAVSFINSIFDCFGSGIVAPQSGVVLHNRGQSFSLKRDHP
NMIAPGKRPLHTIIPGMVTRAGRTEISFGVMGGYYQAMGHAHLISKVIDYGMDLQDAIDLPRLIPVGGKVPRVEAEHTVP
AETIALLRRRGFEIVPAEDPIGGAQIIRIDWENGTLTGASESRKDGIALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=521, Percent_Identity=29.1746641074856, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI73915090, Length=521, Percent_Identity=29.1746641074856, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI73915096, Length=521, Percent_Identity=29.1746641074856, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI73915094, Length=521, Percent_Identity=29.1746641074856, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI113429324, Length=525, Percent_Identity=29.1428571428571, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI113429326, Length=528, Percent_Identity=28.4090909090909, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI109148539, Length=402, Percent_Identity=29.3532338308458, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI153266885, Length=538, Percent_Identity=26.2081784386617, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI153266901, Length=539, Percent_Identity=26.7161410018553, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI153266907, Length=538, Percent_Identity=25.6505576208178, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI30581157, Length=230, Percent_Identity=31.304347826087, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI30581155, Length=230, Percent_Identity=31.304347826087, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789856, Length=539, Percent_Identity=30.0556586270872, Blast_Score=221, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI193208247, Length=553, Percent_Identity=26.5822784810127, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193208245, Length=553, Percent_Identity=26.5822784810127, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI212646519, Length=496, Percent_Identity=25.2016129032258, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=496, Percent_Identity=25.2016129032258, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=467, Percent_Identity=26.338329764454, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17542894, Length=486, Percent_Identity=24.8971193415638, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6323330, Length=556, Percent_Identity=23.021582733813, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18859893, Length=506, Percent_Identity=27.0750988142292, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18859741, Length=531, Percent_Identity=25.4237288135593, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI161077496, Length=523, Percent_Identity=25.8126195028681, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642670, Length=467, Percent_Identity=25.4817987152034, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24642666, Length=467, Percent_Identity=25.4817987152034, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI45551474, Length=467, Percent_Identity=25.4817987152034, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI161077878, Length=467, Percent_Identity=25.4817987152034, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI161077880, Length=467, Percent_Identity=25.4817987152034, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57631; Mature: 57631

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNFEKPTRSVAVSTDAMAATSHPYATLAAINILQAGGNAMDAAIAACAVQCVVEPGSTG
CCCCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCC
IGGDCFALYAPKGGDQVIAYNGSGRTPAALTVDWFEERGLAEVPRQSPSAVTIPGAIDAW
CCCCEEEEECCCCCCEEEEECCCCCCCCEEEEHHHHCCCHHHCCCCCCCEEECCCCHHHH
TRLHADHGRLPFEQILQPAIRYAENGYAITPRVYRDWVREEKLLNDDPAASEIFLPNGRA
HHHCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCCCCCCEEECCCCCC
PQIGEVHHQPRLAATLRRIAAEGRDGFYKGAVAEDMVDRLRALGGLHTLEDFAEAKGEYV
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEE
VPVTTTFRDHTIHECPPNGQGIIALLILNILSRFDTQDDPSSADRLHLEIEATRLAYAAR
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHH
DAWLADPEKASVPVEDMLSEEFATHLAGMIDLTRALTNLPDFEMPLHRDTVYISVIDSER
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC
NAVSFINSIFDCFGSGIVAPQSGVVLHNRGQSFSLKRDHPNMIAPGKRPLHTIIPGMVTR
HHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHC
AGRTEISFGVMGGYYQAMGHAHLISKVIDYGMDLQDAIDLPRLIPVGGKVPRVEAEHTVP
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEECCCCCCCCCCCCCCCC
AETIALLRRRGFEIVPAEDPIGGAQIIRIDWENGTLTGASESRKDGIALGY
HHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRNFEKPTRSVAVSTDAMAATSHPYATLAAINILQAGGNAMDAAIAACAVQCVVEPGSTG
CCCCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCC
IGGDCFALYAPKGGDQVIAYNGSGRTPAALTVDWFEERGLAEVPRQSPSAVTIPGAIDAW
CCCCEEEEECCCCCCEEEEECCCCCCCCEEEEHHHHCCCHHHCCCCCCCEEECCCCHHHH
TRLHADHGRLPFEQILQPAIRYAENGYAITPRVYRDWVREEKLLNDDPAASEIFLPNGRA
HHHCCCCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCCCCCCEEECCCCCC
PQIGEVHHQPRLAATLRRIAAEGRDGFYKGAVAEDMVDRLRALGGLHTLEDFAEAKGEYV
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEE
VPVTTTFRDHTIHECPPNGQGIIALLILNILSRFDTQDDPSSADRLHLEIEATRLAYAAR
EEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHH
DAWLADPEKASVPVEDMLSEEFATHLAGMIDLTRALTNLPDFEMPLHRDTVYISVIDSER
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC
NAVSFINSIFDCFGSGIVAPQSGVVLHNRGQSFSLKRDHPNMIAPGKRPLHTIIPGMVTR
HHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHC
AGRTEISFGVMGGYYQAMGHAHLISKVIDYGMDLQDAIDLPRLIPVGGKVPRVEAEHTVP
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEECCCCCCCCCCCCCCCC
AETIALLRRRGFEIVPAEDPIGGAQIIRIDWENGTLTGASESRKDGIALGY
HHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]