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The map label for this gene is tcyB [H]

Identifier: 222102584

GI number: 222102584

Start: 191612

End: 192271

Strand: Direct

Name: tcyB [H]

Synonym: Avi_7225

Alternate gene names: 222102584

Gene position: 191612-192271 (Clockwise)

Preceding gene: 222102583

Following gene: 222102585

Centisome position: 30.33

GC content: 55.61

Gene sequence:

>660_bases
ATGGTGGATTCGCTTGTCCCTCTTCTGTGGGCAGGGTTGGTGTTTACCATTCCGCTAACGATACTTTCCTTCACGTTCGG
CTTGACACTTGGGCTTGTTACGGCCATCGGCCGGCTGTTCGGAGCGAAACCGGTGGCGGCGATTGCCCGCTTTTATGTTT
GGGTCATTCGTGGCACCCCTCTACTTGTCCAGCTTTTTGTAATTTTCTACGGCTTGCCAAGCATTGGTATTTTGCTGGAT
GCCTTTCCAGCGGCGCTCATCGGCTTCACGCTGAACATAGGGGCCTATAGTTCTGAAATCATTCGCGCTGTCATCTCCTC
CGTGCCGAAGGGACAATGGGAAGCGGCCTATTCGATTGGTATGAGCTGGCGTCAAGCCATGCTGCGCACGATCCTGCCGC
AAGCGGCTCGTGTCGCCGTGCCGCCGCTGTCCAACACGTTCATCTCTCTGGTGAAAGATACGTCGCTCGCTGCCGCCATT
ACCGTGCCAGAACTGTTTCAGGCGGCTCAACGCATTGTCGCCACCACCTATGAACCACTGATCCTCTATATCGAAGCGGC
ATTGATCTATCTTGCCCTGTGCTCTGTGCTCTCGACAGTGCAGGTGCGGTTGGAGCGTCGCTTTGCCCGCTATGGCGGTA
TGATGGAGTCCAACGCATGA

Upstream 100 bases:

>100_bases
GTTTAAACCGCCCTATATTCACGTGAAGAGCGCCCGGCGGGATTGTCTGCCGGGCGCATCTCTTTTGAGGAAGATGTCTT
TGCCGCACTGGATTCAATTG

Downstream 100 bases:

>100_bases
TCGAGCTCTCCAATATCGAAAAGCGTTTCGGTGAGGCTGTTATCCTGAATGATATCAACCTGCGCATCCCGGAAGGAAAT
GTTACGGCGCTAGTCGGACC

Product: ABC transporter membrane spanning protein (amino acid)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MVDSLVPLLWAGLVFTIPLTILSFTFGLTLGLVTAIGRLFGAKPVAAIARFYVWVIRGTPLLVQLFVIFYGLPSIGILLD
AFPAALIGFTLNIGAYSSEIIRAVISSVPKGQWEAAYSIGMSWRQAMLRTILPQAARVAVPPLSNTFISLVKDTSLAAAI
TVPELFQAAQRIVATTYEPLILYIEAALIYLALCSVLSTVQVRLERRFARYGGMMESNA

Sequences:

>Translated_219_residues
MVDSLVPLLWAGLVFTIPLTILSFTFGLTLGLVTAIGRLFGAKPVAAIARFYVWVIRGTPLLVQLFVIFYGLPSIGILLD
AFPAALIGFTLNIGAYSSEIIRAVISSVPKGQWEAAYSIGMSWRQAMLRTILPQAARVAVPPLSNTFISLVKDTSLAAAI
TVPELFQAAQRIVATTYEPLILYIEAALIYLALCSVLSTVQVRLERRFARYGGMMESNA
>Mature_219_residues
MVDSLVPLLWAGLVFTIPLTILSFTFGLTLGLVTAIGRLFGAKPVAAIARFYVWVIRGTPLLVQLFVIFYGLPSIGILLD
AFPAALIGFTLNIGAYSSEIIRAVISSVPKGQWEAAYSIGMSWRQAMLRTILPQAARVAVPPLSNTFISLVKDTSLAAAI
TVPELFQAAQRIVATTYEPLILYIEAALIYLALCSVLSTVQVRLERRFARYGGMMESNA

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=55.9808612440191, Blast_Score=218, Evalue=2e-58,
Organism=Escherichia coli, GI1787030, Length=204, Percent_Identity=37.7450980392157, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788645, Length=221, Percent_Identity=36.6515837104072, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082239, Length=208, Percent_Identity=34.1346153846154, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788646, Length=209, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787086, Length=213, Percent_Identity=31.4553990610329, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787087, Length=220, Percent_Identity=30, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786873, Length=214, Percent_Identity=33.1775700934579, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786874, Length=219, Percent_Identity=26.4840182648402, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI48994930, Length=164, Percent_Identity=34.7560975609756, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 23785; Mature: 23785

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSLVPLLWAGLVFTIPLTILSFTFGLTLGLVTAIGRLFGAKPVAAIARFYVWVIRGTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCH
LLVQLFVIFYGLPSIGILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPKGQWEAAYSIG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHH
MSWRQAMLRTILPQAARVAVPPLSNTFISLVKDTSLAAAITVPELFQAAQRIVATTYEPL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILYIEAALIYLALCSVLSTVQVRLERRFARYGGMMESNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVDSLVPLLWAGLVFTIPLTILSFTFGLTLGLVTAIGRLFGAKPVAAIARFYVWVIRGTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCH
LLVQLFVIFYGLPSIGILLDAFPAALIGFTLNIGAYSSEIIRAVISSVPKGQWEAAYSIG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHH
MSWRQAMLRTILPQAARVAVPPLSNTFISLVKDTSLAAAITVPELFQAAQRIVATTYEPL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILYIEAALIYLALCSVLSTVQVRLERRFARYGGMMESNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]