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The map label for this gene is livM [H]

Identifier: 222102530

GI number: 222102530

Start: 125455

End: 126507

Strand: Direct

Name: livM [H]

Synonym: Avi_7158

Alternate gene names: 222102530

Gene position: 125455-126507 (Clockwise)

Preceding gene: 222102529

Following gene: 222102531

Centisome position: 19.86

GC content: 55.65

Gene sequence:

>1053_bases
ATGACGAACCTTGAATTGCCGTTGGTGACCCATCCCGTGCAGAACATTGGCCTGAAGGCTGTGGGCCTTGTGGCACTTGT
TATCCTGCTGTTGGCTGCTCCCTTTCTGACCTCTGAATATTGGATCAATGCCATCATTGTGCCCTTCCTGATCCTGTCGC
TTGCAGGGTTGGGGCTGAACCTTCTCACCGGTTATGCGGGGCAATTGTCTCTGGGCGCAGGCGCTTTCATGATGGTGGGG
GCCTATGCAACCTTCGCCTTCCAGCTTCGGGTTCCAGAATTGCCCTTGCCGCTGGCGCTGATCATCTCCGGCCTGATTTC
TGGCGTGGTTGGCTTGGCCTTTGGCCTGCCCTCCACGCGCATCAAGGGCTTTTACCTGATTGTCAGCACACTCACGGCGC
AGTTCTTCTTTGAGTGGTTGTTTTTGAAATTTCCGTGGTTTTACAATGGCAATTCATCCGCAACCATTGCCCTGCCGCAT
GGACTTTCCGTGTTTGGGCTGGATCTCAACAATCCCCACGGTCGGTATTTTCTCACCCTTGGCAGTGTGGCATTGCTGAC
CTGGCTGTCGTTCAATCTGGTGCGCAGCCAGACAGGCCGCAACTGGATGGCCATCCGCGATATGGATACGGCGGCAGCCG
TGATTGGTGTTCCCACCTTCCGCGCCAAGCTGCAAGCTTTCGCGGTGTCCAGTTTCATCCTTGGTATTGCCGGTGCGCTG
TGGGCCTTTACCTATCTCGGATCGGCCAGTGTTCAGAGTTTTGGCCTCACCCGTTCTTACCAGATCCTCTTCATCATCAT
TATCGGTGGCCTTGGCACCATCAGGGGTGCCTATCTGGGGGCGGCTTTCGTCAGTCTGCTGCCTTTGGCGCTCGATTGGC
TGTTTCAATATCTGTTCAGCGGCCATGTGGATGCAGGGCTGCTGCAAAATATCCAGAAGGCAATCTTCGGCATTCTCATC
ATCTGGTTTCTGATCAAGGAACCTGAGGGTCTGTCGCGCCTGCTCGGTTTGCGGCGTGCGCATGGCGCACGTCGGCGTCT
CTTTCCCTCCTAA

Upstream 100 bases:

>100_bases
CGGTATCACGCCGTGGTTTGCCTATGCGCTGGCCCTTGTCTTCCTGTTCATCCGCCCCGCCGGTCTTTTCGGCGAACGCC
AGATTGAAAGGGTTTGATCG

Downstream 100 bases:

>100_bases
CCACAAGAGTGAACCCTATGAAACGTTTTGTTATTGCTGCACTTTTTGCCAGCACCATCTTCTCGGCAAGCGCGCCAGCC
TTTGCCGCAGATGTCAGTCA

Product: ABC transporter membrane spanning protein (branched chain amino acid)

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTNLELPLVTHPVQNIGLKAVGLVALVILLLAAPFLTSEYWINAIIVPFLILSLAGLGLNLLTGYAGQLSLGAGAFMMVG
AYATFAFQLRVPELPLPLALIISGLISGVVGLAFGLPSTRIKGFYLIVSTLTAQFFFEWLFLKFPWFYNGNSSATIALPH
GLSVFGLDLNNPHGRYFLTLGSVALLTWLSFNLVRSQTGRNWMAIRDMDTAAAVIGVPTFRAKLQAFAVSSFILGIAGAL
WAFTYLGSASVQSFGLTRSYQILFIIIIGGLGTIRGAYLGAAFVSLLPLALDWLFQYLFSGHVDAGLLQNIQKAIFGILI
IWFLIKEPEGLSRLLGLRRAHGARRRLFPS

Sequences:

>Translated_350_residues
MTNLELPLVTHPVQNIGLKAVGLVALVILLLAAPFLTSEYWINAIIVPFLILSLAGLGLNLLTGYAGQLSLGAGAFMMVG
AYATFAFQLRVPELPLPLALIISGLISGVVGLAFGLPSTRIKGFYLIVSTLTAQFFFEWLFLKFPWFYNGNSSATIALPH
GLSVFGLDLNNPHGRYFLTLGSVALLTWLSFNLVRSQTGRNWMAIRDMDTAAAVIGVPTFRAKLQAFAVSSFILGIAGAL
WAFTYLGSASVQSFGLTRSYQILFIIIIGGLGTIRGAYLGAAFVSLLPLALDWLFQYLFSGHVDAGLLQNIQKAIFGILI
IWFLIKEPEGLSRLLGLRRAHGARRRLFPS
>Mature_349_residues
TNLELPLVTHPVQNIGLKAVGLVALVILLLAAPFLTSEYWINAIIVPFLILSLAGLGLNLLTGYAGQLSLGAGAFMMVGA
YATFAFQLRVPELPLPLALIISGLISGVVGLAFGLPSTRIKGFYLIVSTLTAQFFFEWLFLKFPWFYNGNSSATIALPHG
LSVFGLDLNNPHGRYFLTLGSVALLTWLSFNLVRSQTGRNWMAIRDMDTAAAVIGVPTFRAKLQAFAVSSFILGIAGALW
AFTYLGSASVQSFGLTRSYQILFIIIIGGLGTIRGAYLGAAFVSLLPLALDWLFQYLFSGHVDAGLLQNIQKAIFGILII
WFLIKEPEGLSRLLGLRRAHGARRRLFPS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=269, Percent_Identity=30.4832713754647, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 37985; Mature: 37853

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLELPLVTHPVQNIGLKAVGLVALVILLLAAPFLTSEYWINAIIVPFLILSLAGLGLN
CCCCCCCCEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLTGYAGQLSLGAGAFMMVGAYATFAFQLRVPELPLPLALIISGLISGVVGLAFGLPSTR
HHHCCCCCEECCCCHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
IKGFYLIVSTLTAQFFFEWLFLKFPWFYNGNSSATIALPHGLSVFGLDLNNPHGRYFLTL
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEEEEECCCCCCEEEEEH
GSVALLTWLSFNLVRSQTGRNWMAIRDMDTAAAVIGVPTFRAKLQAFAVSSFILGIAGAL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WAFTYLGSASVQSFGLTRSYQILFIIIIGGLGTIRGAYLGAAFVSLLPLALDWLFQYLFS
HHHHHHCCCCHHHHCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHVDAGLLQNIQKAIFGILIIWFLIKEPEGLSRLLGLRRAHGARRRLFPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TNLELPLVTHPVQNIGLKAVGLVALVILLLAAPFLTSEYWINAIIVPFLILSLAGLGLN
CCCCCCCEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLTGYAGQLSLGAGAFMMVGAYATFAFQLRVPELPLPLALIISGLISGVVGLAFGLPSTR
HHHCCCCCEECCCCHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
IKGFYLIVSTLTAQFFFEWLFLKFPWFYNGNSSATIALPHGLSVFGLDLNNPHGRYFLTL
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEEEEECCCCCCEEEEEH
GSVALLTWLSFNLVRSQTGRNWMAIRDMDTAAAVIGVPTFRAKLQAFAVSSFILGIAGAL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WAFTYLGSASVQSFGLTRSYQILFIIIIGGLGTIRGAYLGAAFVSLLPLALDWLFQYLFS
HHHHHHCCCCHHHHCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHVDAGLLQNIQKAIFGILIIWFLIKEPEGLSRLLGLRRAHGARRRLFPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]