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The map label for this gene is livH [H]

Identifier: 222102483

GI number: 222102483

Start: 80521

End: 81390

Strand: Direct

Name: livH [H]

Synonym: Avi_7090

Alternate gene names: 222102483

Gene position: 80521-81390 (Clockwise)

Preceding gene: 222102482

Following gene: 222102484

Centisome position: 12.75

GC content: 59.2

Gene sequence:

>870_bases
ATGACCCTGTCGGATATGCTGGAATTGTTAATACAGGGTTTGACGCTGGGTGGTCTCTATGGCCTCGTGGGTGCTGGCCT
TGCCTTGAACTTTGGCGTGCTGAAGGTGGTTAATCTCGTTCATGGCGAGTTGATTACCTGTGGTGGTTTTATCGCAGCCT
TTTGCTTGTCCATGGTGCCCAATATGCCTTTTCCGCTCATTCTGGTGCTGGCGATGGCTGGCACAGCACTGGTGGGGGCG
GGCCTTCAGGCGCTTGTTGTCGAGCGGGCCATGACAACGCGCGATCCCATGGTGACTATGCTTGTCACCTTCGGACTGGG
CATTGTTGCACGCAATGTGATGGTCGAGCTTTTCGGCGCGGACCTGCGGGGACTTGATGTGGGCGGTCTCAGCCATGCCC
GCCTCCAGATCGGTACGGTTTCCGTGGGCGTTTTGCCCTTGATGACCTTTGCCTTCGCTCTGGCGGCCTTTGCGGTACTG
CATGTTCTGGTCAACATGACGGCCTTTGGACGCGCGGTGCGCGCCACATCGGATCGGCCCGACATTGCAAGGTTGATGGG
GGTTCGGGTGCGAACACTCCACATCAAAGTCGCGGCCCTTGCCGCCGCGCTGGCCGCGTTGGCGGGGATGTTGCTGGCGA
TGCGGGCGTCAATCTCGCCCTATTCCGGGGTTGAACGTTTGATCGTGGCCTTCGAGGTGGTGGTGCTCGGCGGGGTCGGG
TCTATTCGTGGAGCGCTGATCGCCGGTCTTGTGCTTGGAACTGCACAGGTTGTTACCGCCCGTTTCGATGGCAACGCGGG
CCTGCTTTATGTCCACCTGACGTTTCTTGCAGGTCTTGGTCTGCGTGCTTTCCGGGGGAAACTCTCATGA

Upstream 100 bases:

>100_bases
ACCGGGTGGTCTGCATGCTGAAAGGCCGCGTGAGCCATATTAGCCCGGCAGCGGGTGTGACCGCCCATACGCTGAGAGAT
GCCTATTTCGGAGCGGCCCA

Downstream 100 bases:

>100_bases
AACTGCTTGTTCAGAGCATGGCTCTGGTTGCCGTTATCGGTTCGGTCGCTTTTTTCGCCAGCGGATATATCGATCCCGGA
TTGCTCTATCTGCTCTCTGA

Product: ABC transporter membrane spanning protein (urea/amide)

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTLSDMLELLIQGLTLGGLYGLVGAGLALNFGVLKVVNLVHGELITCGGFIAAFCLSMVPNMPFPLILVLAMAGTALVGA
GLQALVVERAMTTRDPMVTMLVTFGLGIVARNVMVELFGADLRGLDVGGLSHARLQIGTVSVGVLPLMTFAFALAAFAVL
HVLVNMTAFGRAVRATSDRPDIARLMGVRVRTLHIKVAALAAALAALAGMLLAMRASISPYSGVERLIVAFEVVVLGGVG
SIRGALIAGLVLGTAQVVTARFDGNAGLLYVHLTFLAGLGLRAFRGKLS

Sequences:

>Translated_289_residues
MTLSDMLELLIQGLTLGGLYGLVGAGLALNFGVLKVVNLVHGELITCGGFIAAFCLSMVPNMPFPLILVLAMAGTALVGA
GLQALVVERAMTTRDPMVTMLVTFGLGIVARNVMVELFGADLRGLDVGGLSHARLQIGTVSVGVLPLMTFAFALAAFAVL
HVLVNMTAFGRAVRATSDRPDIARLMGVRVRTLHIKVAALAAALAALAGMLLAMRASISPYSGVERLIVAFEVVVLGGVG
SIRGALIAGLVLGTAQVVTARFDGNAGLLYVHLTFLAGLGLRAFRGKLS
>Mature_288_residues
TLSDMLELLIQGLTLGGLYGLVGAGLALNFGVLKVVNLVHGELITCGGFIAAFCLSMVPNMPFPLILVLAMAGTALVGAG
LQALVVERAMTTRDPMVTMLVTFGLGIVARNVMVELFGADLRGLDVGGLSHARLQIGTVSVGVLPLMTFAFALAAFAVLH
VLVNMTAFGRAVRATSDRPDIARLMGVRVRTLHIKVAALAAALAALAGMLLAMRASISPYSGVERLIVAFEVVVLGGVGS
IRGALIAGLVLGTAQVVTARFDGNAGLLYVHLTFLAGLGLRAFRGKLS

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=268, Percent_Identity=25, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 29878; Mature: 29746

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSDMLELLIQGLTLGGLYGLVGAGLALNFGVLKVVNLVHGELITCGGFIAAFCLSMVP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
NMPFPLILVLAMAGTALVGAGLQALVVERAMTTRDPMVTMLVTFGLGIVARNVMVELFGA
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DLRGLDVGGLSHARLQIGTVSVGVLPLMTFAFALAAFAVLHVLVNMTAFGRAVRATSDRP
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIARLMGVRVRTLHIKVAALAAALAALAGMLLAMRASISPYSGVERLIVAFEVVVLGGVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
SIRGALIAGLVLGTAQVVTARFDGNAGLLYVHLTFLAGLGLRAFRGKLS
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
TLSDMLELLIQGLTLGGLYGLVGAGLALNFGVLKVVNLVHGELITCGGFIAAFCLSMVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
NMPFPLILVLAMAGTALVGAGLQALVVERAMTTRDPMVTMLVTFGLGIVARNVMVELFGA
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DLRGLDVGGLSHARLQIGTVSVGVLPLMTFAFALAAFAVLHVLVNMTAFGRAVRATSDRP
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIARLMGVRVRTLHIKVAALAAALAALAGMLLAMRASISPYSGVERLIVAFEVVVLGGVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCH
SIRGALIAGLVLGTAQVVTARFDGNAGLLYVHLTFLAGLGLRAFRGKLS
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]