Click here to switch to the map view.

The map label for this gene is hslU [H]

Identifier: 222097274

GI number: 222097274

Start: 3575988

End: 3577379

Strand: Reverse

Name: hslU [H]

Synonym: BCQ_3614

Alternate gene names: 222097274

Gene position: 3577379-3575988 (Counterclockwise)

Preceding gene: 222097275

Following gene: 222097273

Centisome position: 68.61

GC content: 36.71

Gene sequence:

>1392_bases
ATGCATTTACATTTTACTCCGCGTCAAATTGTGGAAAAATTAGATCAATACATTATCGGTCAAAAAGATGCGAAGAAAGC
GGTTGCTGTAGCTTTAAGAAATCGATACCGCCGAAGTAAATTAGCTGAAAATCTACGTGATGAAATTGCACCTAAAAATA
TTTTAATGATTGGACCGACAGGTGTTGGTAAAACAGAGGTAGCACGACGAATGGCGAAACTCGTTGGAGCACCTTTTATT
AAGGTTGAAGCTACGAAATTTACAGAAGTTGGATATGTAGGTAGAGATGTAGAATCGATGGTACGTGACCTTGTGGAAAC
GTCAGTTCGCATTGTGAAAGAAGAAATGGTAGTAAAAGTACAAGACAAAGCAGAAGAACAAGCGAACCAACGTCTTGTTG
AAATTTTAGTGCCGAGTCCGGAGAAGCAATCTGGATTTAAAAACCCATTAGAAATGCTATTTGGTGGCGCTCAAAATTCG
AATCAAACAACAGATTCACAGGAAGATGTTGAAATCGAAAAGAAACGTCAAGATGTGGAAAGAAAGCTTGCTGCAGGACT
TCTTGAAGATGAAATTGTATCGATTGAAGTGACTGAACAACAGTCTTCCATGTTCGATATGCTGCAAGGAACTGGCATGG
AACAAATGGGGATGAATTTTCAAGATGCATTAGGAAGTTTTATGCCGAAAAAAACAAAAAAACGTAAACTTTCTGTAAAA
GAAGCAAGAAAAGTCTTGACAAATGAGGAAGCACAGCGCTTAATTGATATGGATGAAGTTACACAAGAGGCTGTTTATCG
TGCTGAACAGCTCGGGATTATTTTTATCGATGAAATTGACAAAATTGCTGGTAAGCAGTCGAATAGTGTAGATGTATCAC
GTGAAGGTGTGCAACGTGACATTTTACCAATTGTAGAAGGATCAAATGTTGCGACAAAATACGGATCAGTAAAAACGGAT
TATATTTTATTCGTTGCAGCTGGAGCGTTTCATATGTCTAAACCGTCAGATTTGATTCCGGAATTACAAGGGAGATTTCC
GATTCGAGTAGAATTAACAAAATTATCGACGGATGATTTTGTTAAAATATTAATCGAGCCTGACAATGCGTTAATTAAAC
AATATATTGCTTTATTAGCGACTGAAGGTATAGAAATTGAATTTTCAGACGAAGCTATTCGTAAGATTGCTGAGATTGCT
TATCAAGTTAATCAGGATACAGATAATATTGGAGCAAGAAGACTTCATACGATTATGGAGAAGCTCCTTGAAGATTTATC
GTTTGAAGCATCTGAAATTACGTTAGAGAAAATAACGATAACGCCTCAATACGTTGAGGAAAAATTAGCAACGATTGCTA
AAAATAAAGATGTGAGCCAGTTTATTTTGTAA

Upstream 100 bases:

>100_bases
ATTGCGAAAGCGAGTTTAAACATTGCAGGCGATATTTGTGTGTATACAAACCACAATATAATTGTGGAAGAATTGTAGAA
TCGTAAGGGAGGCATTTTAT

Downstream 100 bases:

>100_bases
TAGTGTCATCAGGTGACTCGCCCTAGTTTCCAAGTGATGAAAAAATATGTGAGTAACATGTAGGAGGAACTTTTGAAATG
GAATTATTAGCAAAAACAAG

Product: ATP-dependent protease ATP-binding subunit hslu

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNS
NQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYIALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Sequences:

>Translated_463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNS
NQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYIALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
>Mature_463_residues
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPTGVGKTEVARRMAKLVGAPFI
KVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKVQDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNS
NQTTDSQEDVEIEKKRQDVERKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRDILPIVEGSNVATKYGSVKTD
YILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDFVKILIEPDNALIKQYIALLATEGIEIEFSDEAIRKIAEIA
YQVNQDTDNIGARRLHTIMEKLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.9369369369369, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=50.8695652173913, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=46.078431372549, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=141, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24648291, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24648289, Length=259, Percent_Identity=30.5019305019305, Blast_Score=96, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52166; Mature: 52166

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNSNQTTDSQEDVEIEKKRQDVE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
HHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCHHHHHHCCHH
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRD
HHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHH
ILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDF
CHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCE
VKILIEPDNALIKQYIALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIME
EEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
HHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MHLHFTPRQIVEKLDQYIIGQKDAKKAVAVALRNRYRRSKLAENLRDEIAPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
GVGKTEVARRMAKLVGAPFIKVEATKFTEVGYVGRDVESMVRDLVETSVRIVKEEMVVKV
CCCHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDKAEEQANQRLVEILVPSPEKQSGFKNPLEMLFGGAQNSNQTTDSQEDVEIEKKRQDVE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
RKLAAGLLEDEIVSIEVTEQQSSMFDMLQGTGMEQMGMNFQDALGSFMPKKTKKRKLSVK
HHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCHHHHHHCCHH
EARKVLTNEEAQRLIDMDEVTQEAVYRAEQLGIIFIDEIDKIAGKQSNSVDVSREGVQRD
HHHHHHCCHHHHHHHCHHHHHHHHHHHHHHCCEEEEECHHHHHCCCCCCCCCCHHHHHHH
ILPIVEGSNVATKYGSVKTDYILFVAAGAFHMSKPSDLIPELQGRFPIRVELTKLSTDDF
CHHHCCCCCCEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCE
VKILIEPDNALIKQYIALLATEGIEIEFSDEAIRKIAEIAYQVNQDTDNIGARRLHTIME
EEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KLLEDLSFEASEITLEKITITPQYVEEKLATIAKNKDVSQFIL
HHHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA