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The map label for this gene is gabP [H]

Identifier: 222097179

GI number: 222097179

Start: 3469282

End: 3470631

Strand: Reverse

Name: gabP [H]

Synonym: BCQ_3519

Alternate gene names: 222097179

Gene position: 3470631-3469282 (Counterclockwise)

Preceding gene: 222097181

Following gene: 222097178

Centisome position: 66.56

GC content: 36.52

Gene sequence:

>1350_bases
ATGATCTCAATTGGCGGCGTAATAGGAGCTGGTTTGTTTGTTGGAAGTGGGGCAGTTGTGCATTCAGCAGGACCAGGTTC
TATCGTTTCATATGCATTAGCAGGACTTCTAGTCGTTTTCGTTATGAGAATGCTTGGGGAAATGGCAGCTATTAACCCGA
CAAGTGGGTCATTTGCAACATATGCAAGAGAAGCAATTGGTCCATGGGCCGGTTATACAATTGGGTGGCTATATTGGTTT
TTCTGGGTAATTGTTATTGCAATAGAAGCCACAGCAGGTGCTGGTATTATTCAATACTGGATTCCAGAAATCCCTCTTTG
GTTATTAAGCCTAATATTAACGATTTTATTAACATTGACGAATGTTTTTTCTGTGAAATCATTTGGAGAGTTTGAATATT
GGTTTTCTTTTATTAAAGTAATAAGTATTGTTTTGTTCCTTTGTCTTGGACTAGCTGTTATTTTAGGATTTGTACCAGGA
ACGGAAGCACCTGGCACTTCGAATTTAGTAGGACAAGGAGGATTTATGCCAAACGGTATAAGTTCGGTGCTACTTGGAAT
TACTGTCGTTATATTTTCATTTATGGGATCTGAGATTGTTGCAGTAGCTGCTGGAGAATCTGCTGAACCTGTAAAAGCAG
TAAAAACAGCAACAAATAGTGTAATTTGGCGTATTCTCGTATTTTTCATTGGATCGATTGCTGTAGTTGTTACACTTCTT
CCATGGAATTCAGCGAACATATTAAAAAGTCCGTTTGTAGCGGTACTGGAACATATAGGGATACCAGCGGCAGCACAAAT
TATGAATTTTATCGTTTTAACAGCTGTACTTTCTTGTTTAAATTCTGGTTTATATACGAACTCAAGAATGCTTTTTTCAA
TGGCAGAAAGAGGAGATGCTCCAAAGGCATTTTTGAAATTGAATAGTAGTGGTGTTCCAGTTCGGGCCGTTTTATTCGGA
ACGTTCTTCGCTTATATTGGAGTTGTTTTTAGTTATATATCTCCAGATAAAGTCTTTTTATTTTTAGTCAATGCATCTGG
CGGAATTGCGTTACTCGTTTATCTCGTTATAGCTGTTTCGCATTTAAAGATCCGTAAAAAAATGGGGAAAGTAGAACAAC
AAAATTTGAAAGTGAAAATGTGGTTTTTCCCGTATGTAACGTATGTTACAATTGCCGCTATTATAGCTGTTTTAGTTGCG
ATGCTTGCAATTGAATCTTTACGTTCACAAGCACTTTTGACGATGCTTGTTACTGTTCTTATAATACTTTCTTATTTTAT
TTTTAATAGAAATAAAAATAGTACAGTATCGAATACTACAAGTAAGAATGAGGAATCTGTGCGATTCTAA

Upstream 100 bases:

>100_bases
ACATAATACTCTTACATAAATTTCAAAATTACGTTTGGAAGGGGATGTATAAGAGTTGGATAAAAATCTTAAGAAAGACC
TCAAAATACGCCACATTACA

Downstream 100 bases:

>100_bases
TTTCTTGTTTTCGAAGAGAGTTACACCCAATCATTGCTATAAAAGAATCATATATAATCATAAAAATGAGTAATTACTAT
TGTCATAGTGAATATAAACT

Product: gaba permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWF
FWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPG
TEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFLKLNSSGVPVRAVLFG
TFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVSHLKIRKKMGKVEQQNLKVKMWFFPYVTYVTIAAIIAVLVA
MLAIESLRSQALLTMLVTVLIILSYFIFNRNKNSTVSNTTSKNEESVRF

Sequences:

>Translated_449_residues
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWF
FWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPG
TEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFLKLNSSGVPVRAVLFG
TFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVSHLKIRKKMGKVEQQNLKVKMWFFPYVTYVTIAAIIAVLVA
MLAIESLRSQALLTMLVTVLIILSYFIFNRNKNSTVSNTTSKNEESVRF
>Mature_449_residues
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWF
FWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPG
TEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFLKLNSSGVPVRAVLFG
TFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVSHLKIRKKMGKVEQQNLKVKMWFFPYVTYVTIAAIIAVLVA
MLAIESLRSQALLTMLVTVLIILSYFIFNRNKNSTVSNTTSKNEESVRF

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=355, Percent_Identity=25.6338028169014, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI258614003, Length=355, Percent_Identity=25.6338028169014, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI258645169, Length=354, Percent_Identity=25.4237288135593, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4507047, Length=414, Percent_Identity=24.6376811594203, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=50.4608294930876, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI48994972, Length=441, Percent_Identity=37.6417233560091, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1786302, Length=403, Percent_Identity=38.7096774193548, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI87081708, Length=440, Percent_Identity=35.9090909090909, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1788480, Length=399, Percent_Identity=39.5989974937343, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1786789, Length=431, Percent_Identity=34.338747099768, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1790653, Length=417, Percent_Identity=36.9304556354916, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1786602, Length=441, Percent_Identity=35.1473922902494, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI87081915, Length=397, Percent_Identity=38.2871536523929, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI2367353, Length=437, Percent_Identity=24.9427917620137, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=363, Percent_Identity=23.4159779614325, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=411, Percent_Identity=33.8199513381995, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324061, Length=411, Percent_Identity=33.0900243309002, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320717, Length=417, Percent_Identity=30.2158273381295, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324059, Length=390, Percent_Identity=31.5384615384615, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=384, Percent_Identity=33.0729166666667, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=467, Percent_Identity=27.6231263383298, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=383, Percent_Identity=32.8981723237598, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=28.4037558685446, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=390, Percent_Identity=30, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321053, Length=409, Percent_Identity=29.5843520782396, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=394, Percent_Identity=31.2182741116751, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=391, Percent_Identity=28.3887468030691, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=381, Percent_Identity=26.246719160105, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=395, Percent_Identity=27.8481012658228, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=327, Percent_Identity=30.5810397553517, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=426, Percent_Identity=24.8826291079812, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324981, Length=390, Percent_Identity=27.1794871794872, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=476, Percent_Identity=22.4789915966387, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221512776, Length=319, Percent_Identity=23.1974921630094, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24666159, Length=319, Percent_Identity=23.1974921630094, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24668806, Length=396, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21356285, Length=396, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24668802, Length=396, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24667468, Length=362, Percent_Identity=23.4806629834254, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48341; Mature: 48341

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFAT
CCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
YAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
SSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
PKAFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVS
CHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
HLKIRKKMGKVEQQNLKVKMWFFPYVTYVTIAAIIAVLVAMLAIESLRSQALLTMLVTVL
HHHHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IILSYFIFNRNKNSTVSNTTSKNEESVRF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFAT
CCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
YAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
SSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
PKAFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVS
CHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
HLKIRKKMGKVEQQNLKVKMWFFPYVTYVTIAAIIAVLVAMLAIESLRSQALLTMLVTVL
HHHHHHHHCCHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IILSYFIFNRNKNSTVSNTTSKNEESVRF
HHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]