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The map label for this gene is argH [H]

Identifier: 222097003

GI number: 222097003

Start: 3287794

End: 3289302

Strand: Reverse

Name: argH [H]

Synonym: BCQ_3343

Alternate gene names: 222097003

Gene position: 3289302-3287794 (Counterclockwise)

Preceding gene: 222097004

Following gene: 222097002

Centisome position: 63.08

GC content: 34.79

Gene sequence:

>1509_bases
ATGAAACAAAGTAAAGAAGAGTTTATAAAGAGTGAAGGCGCTGATTTCCCTGGGAAAACATATGTGGATTGTGTATTACA
ACATGTATTTAATTTTCAACGAAATTACTTATTGAAAGATATGTTTCAAGTGCATAAAGCGCATATTACGATGCTGATGG
AAGAAAATTTAATGAAAAAGGAAGAAGCTAAAGTTATATTACACGCGTTAAAAAAGGTAGAGGGAATGCCAGAAGAGCAA
TTGCTCTATACAGAGCAGCATGAAGATCTCTTTTTTTTAGTGGAACATTTAATTTCTCAAGAAGCAAAAAGCAATTTTGT
AAGTAATATGCATATTGGTAGAAGTAGAAATGATATGGGTGTCACGATGTATCGCATGAGTTTAAGACGGTATGTATTAC
GATTAATGGAACATCATTTGTTATTGCAAGAGAGTATATTGCAACTTGCTGCTGATCATAAGGAAACGATTATGCCAGCT
TATACCCATACACAACCAGCGCAGCCAACGACATTTGGTCATTATACGTTAGCGATTTATGATACGATGCAGAGAGATTT
AGAACGCATGAAAAAAACGTACAAACTTTTAAATCAGTCTCCAATGGGAGCCGCTGCGCTAGCTACAACAAGTTTCCCAA
TTAAACGAGAGCGAGTTGCCGAGTTACTTGGGTTTACAAATGTAATTGAGAACTCATATGATGCTGTTGCTGGAGCGGAT
TATTTATTAGAAGTTAGCTCTTTACTTATGGTAATGATGACGAATACGAGCAGATGGATCCATGACTTCTTACTATTAGC
GACGAAAGAATATGATGGTATTACTGTGGCGAAGCCATATGTGCAAATTAGTAGTATTATGCCGCAAAAGCGAAATCCAG
TTTCCATTGAACACGCCCGTGCAATTACGAGTAGTGCTTTAGGAGAAGCATTTACAGTATTTCAAATGATTCATAATACA
CCATTTGGTGATATTGTTGATACAGAGGATGACTTGCAGCCATACTTATATAAAGGGATTGAAAAGACTATTCGTGTTTT
TTCTATTATGAATGCAGTTATTCGAACGATGAAGGTTGAGGAAGAAACGTTGAAAAATCGTTCCTATAAACATGCAATTA
CGATAACTGATTTCGCAGATGCTTTAACAAAAAACTATGACATTCCATTTCGGCATGCGCATCATGCAGCGAGTGCTATT
GCAAATATGTTATTGGAGCAGAAAAAGGAGCTTCATGAATTACATTTGAAAGATGTGAATATGTACTTACAAGAAAAATT
TAATATAACTTTATTAGAAAAAGAGTGGAAAGAAATTATATCGCCAAAAGCTTTTATACAAAAAAGAAATGTATACGGTG
GGCCGAGTAAAAAAGAAATGGAGCGCATGATTAACAATCGAAAAGAGTTATTTCAGCAAGAAGAAGAGGTATTTGAAAAG
GAAAAACAGAGAATTTTACAAGCTGAAAATAATTTGAATACGTTAGCTTTGAATATTATTGAATCGTAA

Upstream 100 bases:

>100_bases
CTCGGTGCAGAGAGCACCGAGTTTATTTTTGTGTACAAGCACTTTTTTGCTATCTCTGGGTATGATGGGTAGTAATACTT
AGGTGAAAGGGGAAAAGGTG

Downstream 100 bases:

>100_bases
AAGAGGGATTTAGTGAATTAATCGCCAATACCTTAATAAAACTATAAATAGAGAGAAGAGATTGTCGATGATTCAATTGC
ATGTATATGAAGAGATTGTT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHITMLMEENLMKKEEAKVILHALKKVEGMPEEQ
LLYTEQHEDLFFLVEHLISQEAKSNFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALATTSFPIKRERVAELLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKTIRVFSIMNAVIRTMKVEEETLKNRSYKHAITITDFADALTKNYDIPFRHAHHAASAI
ANMLLEQKKELHELHLKDVNMYLQEKFNITLLEKEWKEIISPKAFIQKRNVYGGPSKKEMERMINNRKELFQQEEEVFEK
EKQRILQAENNLNTLALNIIES

Sequences:

>Translated_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHITMLMEENLMKKEEAKVILHALKKVEGMPEEQ
LLYTEQHEDLFFLVEHLISQEAKSNFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALATTSFPIKRERVAELLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKTIRVFSIMNAVIRTMKVEEETLKNRSYKHAITITDFADALTKNYDIPFRHAHHAASAI
ANMLLEQKKELHELHLKDVNMYLQEKFNITLLEKEWKEIISPKAFIQKRNVYGGPSKKEMERMINNRKELFQQEEEVFEK
EKQRILQAENNLNTLALNIIES
>Mature_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHITMLMEENLMKKEEAKVILHALKKVEGMPEEQ
LLYTEQHEDLFFLVEHLISQEAKSNFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALATTSFPIKRERVAELLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKTIRVFSIMNAVIRTMKVEEETLKNRSYKHAITITDFADALTKNYDIPFRHAHHAASAI
ANMLLEQKKELHELHLKDVNMYLQEKFNITLLEKEWKEIISPKAFIQKRNVYGGPSKKEMERMINNRKELFQQEEEVFEK
EKQRILQAENNLNTLALNIIES

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=417, Percent_Identity=27.5779376498801, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI68303542, Length=417, Percent_Identity=27.5779376498801, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI68303547, Length=417, Percent_Identity=27.8177458033573, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI68303549, Length=417, Percent_Identity=25.6594724220624, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1790398, Length=416, Percent_Identity=27.8846153846154, Blast_Score=178, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6321806, Length=473, Percent_Identity=27.061310782241, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221473854, Length=425, Percent_Identity=27.0588235294118, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI78706858, Length=425, Percent_Identity=27.0588235294118, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 58348; Mature: 58348

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHITMLMEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEAKVILHALKKVEGMPEEQLLYTEQHEDLFFLVEHLISQEAKSNFVSNMHIGRSRNDMG
HHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFGHYTLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHH
DTMQRDLERMKKTYKLLNQSPMGAAALATTSFPIKRERVAELLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHH
AITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKTIRVFSIMNAVIRTMKVE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EETLKNRSYKHAITITDFADALTKNYDIPFRHAHHAASAIANMLLEQKKELHELHLKDVN
HHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYLQEKFNITLLEKEWKEIISPKAFIQKRNVYGGPSKKEMERMINNRKELFQQEEEVFEK
HHHHHCCCEEEEHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKQRILQAENNLNTLALNIIES
HHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHITMLMEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEAKVILHALKKVEGMPEEQLLYTEQHEDLFFLVEHLISQEAKSNFVSNMHIGRSRNDMG
HHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFGHYTLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHH
DTMQRDLERMKKTYKLLNQSPMGAAALATTSFPIKRERVAELLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHH
AITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKTIRVFSIMNAVIRTMKVE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EETLKNRSYKHAITITDFADALTKNYDIPFRHAHHAASAIANMLLEQKKELHELHLKDVN
HHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYLQEKFNITLLEKEWKEIISPKAFIQKRNVYGGPSKKEMERMINNRKELFQQEEEVFEK
HHHHHCCCEEEEHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKQRILQAENNLNTLALNIIES
HHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]