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The map label for this gene is mutS [H]

Identifier: 222096952

GI number: 222096952

Start: 3233420

End: 3235321

Strand: Reverse

Name: mutS [H]

Synonym: BCQ_3292

Alternate gene names: 222096952

Gene position: 3235321-3233420 (Counterclockwise)

Preceding gene: 222096955

Following gene: 222096951

Centisome position: 62.05

GC content: 32.12

Gene sequence:

>1902_bases
ATGAATACAATGACTTTTGAAAAGTTACAATATAACGAATTAAAGGATATAGTGAAATCTTATTGTGTAAGTGGATTAGG
AAAAGAATTAATAAATAAATTAGAGCCGAGTGCAAGTATAAAAGTAGTAAGGAATCGATTGAATGAAACAACCGAAGCGC
GAGCTATATTAGATGCAGAAGGGCATGTTCCTTTCTTCGGTATTTCAAATATCGCAAGTACAATTCAAAAATTAGAAAAA
GGGATGATTTTAGATCCAGAAGAATTAGTCAGCGTTTCAGACTTTTTACGCGGATGTAGAAAGATTAAAAAATTTATGTT
AGATAAAGAATTTTTTGCACCAGTATTAGCTTCTTATGCAAATTCAATGACTGAATATAAAAGTATTGAAGAAGAAATTA
ACTTTTCAATTAAAGGAAATAGTATTGATTCTGCCGCTAGTAAAGAGTTAAAACGAATTCGAAATAACATGGATTCGGTA
GATGGGAAAATAAAAGAACGTTTAACGAAGTTTTTAAATAGCAGTGCAAATAAGAAGTATATTCAGGAGTTCTTTATTAG
TAAAAAAGATGATCGTTATACGATTCCGATTAAATCTTCTTATAAAAATCAAGTTGCCGGAAGTATTGTTGAAGCGTCGG
CTAAAGGTTCTACTGTATTTATAGAACCGCATACGGTTACAAAGTTAAATGCGGAACTGGCAAGTTTGAAAGCAGAAGAA
GCGATGGAAGAATATCAAATTTTAGCGACTTTATCAGGAATGGTAGTAGAAAATATATATCATATAAAAATTAATATGGA
ATTAATTAGTCAGTATGATATGGTGTTTGCGAAAGCGAAGTTTAGTAAATCGATTGATGGAATAGAGCCGAAGTTAAATG
ATCATGGCTACGTTCATTTAGTAAATTGTAAGCATCCGCTTTTAAGTGGAAAAGTAGTACCATTAAACTTTGAAATCGGT
CAAAACTATCGTAGTTTAATTATTACAGGGCCGAATGCGGGCGGGAAGACAATTGTGTTAAAGACGATTGGATTGTTAAC
ATTAGCGACAATGTCAGGTTTGCATATTGCCGGAGATAAAGAAACAGAAATTGCTATTTTCGAAAATGTATTTGTAGATA
TTGGTGATAATCAAAGTATCGAAAATGCACTAAGTACATTTTCATCACATATGAAAAATTTATCTGAGATTATGAGGATG
TCAAATAATAATACGTTGCTATTATTTGATGAAATAGGAAGCGGGACTGAACCGAATGAAGGAGCAGCACTTGCAATTTC
TATTTTAGAGGAGTTTTATCTTGCAGGATGTATTACAGTTGCGAGTACGCATTACGGTGAAATTAAACGCTTCTCAGAAA
TGCACGATGATTTCATGAACGCAGCCATGCAATTTAATAGTGAGACGCTAGAACCGCTTTATAAATTAGTGATCGGTAAA
TCAGGTGAAAGTAATGCACTTTGGATTGCAAATAAAATGAACGTAAGAGAACGTGTACTGAAAAGAGCGAAAGAGTACAT
GGAAAATAAAGAATATACTTTAGAAAAAGTGAATGAAAGTAAAATTAGAAAGCCGAAATTCCTGCAAGAAAAAAGAGAAA
ATCATTACGAGTATAAAATTGGCGACCGTGTAAATTTATTGGATCATGATGATTTTGGTATCATCTATAAGGAAAAAGAT
AACTTCTATAATGTCGTTGTATATTATAACGGTGAATTCATTGAAGTGAATGTAAAACGTATTACTTTAGAGGTATCAGC
AAAAGAATTATATCCAGAGGGATACGATTTAAATACGCTATTTGTCGATTATAAAGAAAGAAAAATGCAACATGATATTG
AACGGGGATCGAAAAAAGCACTTCGTAAAATTCAAAAAGAAATGAGAAAGAATAGAGGGTAA

Upstream 100 bases:

>100_bases
ATGTTTAAAAAGGGTAATTGAATAATGTAGAACTCATTGGAATCTAATGAGTAGGTATCTTCATTTATGATAGAAATCAA
TCATAGTGAGGAGAAACAAA

Downstream 100 bases:

>100_bases
TCCAGAGTGGTAACGATTAGACAAGAACGACAAACCGATTATAGAAAAACGGAAGAAGTTGTACAACAAGCATTTTTAAA
TGAAGAATTTAGTGATAAAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MNTMTFEKLQYNELKDIVKSYCVSGLGKELINKLEPSASIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNMDSV
DGKIKERLTKFLNSSANKKYIQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYVHLVNCKHPLLSGKVVPLNFEIG
QNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVRERVLKRAKEYMENKEYTLEKVNESKIRKPKFLQEKRENHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFIEVNVKRITLEVSAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRKIQKEMRKNRG

Sequences:

>Translated_633_residues
MNTMTFEKLQYNELKDIVKSYCVSGLGKELINKLEPSASIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNMDSV
DGKIKERLTKFLNSSANKKYIQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYVHLVNCKHPLLSGKVVPLNFEIG
QNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVRERVLKRAKEYMENKEYTLEKVNESKIRKPKFLQEKRENHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFIEVNVKRITLEVSAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRKIQKEMRKNRG
>Mature_633_residues
MNTMTFEKLQYNELKDIVKSYCVSGLGKELINKLEPSASIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNMDSV
DGKIKERLTKFLNSSANKKYIQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYVHLVNCKHPLLSGKVVPLNFEIG
QNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVRERVLKRAKEYMENKEYTLEKVNESKIRKPKFLQEKRENHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFIEVNVKRITLEVSAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRKIQKEMRKNRG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=260, Percent_Identity=26.9230769230769, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI36949366, Length=548, Percent_Identity=22.992700729927, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI4504191, Length=285, Percent_Identity=24.5614035087719, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI26638666, Length=217, Percent_Identity=30.4147465437788, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4505253, Length=217, Percent_Identity=30.4147465437788, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI26638664, Length=217, Percent_Identity=29.4930875576037, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI262231786, Length=217, Percent_Identity=29.4930875576037, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4557761, Length=184, Percent_Identity=27.7173913043478, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1789089, Length=280, Percent_Identity=24.6428571428571, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=322, Percent_Identity=25.1552795031056, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17534743, Length=187, Percent_Identity=26.7379679144385, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539736, Length=292, Percent_Identity=21.2328767123288, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=396, Percent_Identity=27.2727272727273, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=299, Percent_Identity=26.7558528428094, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320302, Length=249, Percent_Identity=23.2931726907631, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=253, Percent_Identity=24.901185770751, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584320, Length=301, Percent_Identity=28.9036544850498, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664545, Length=544, Percent_Identity=21.875, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 71998; Mature: 71998

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTFEKLQYNELKDIVKSYCVSGLGKELINKLEPSASIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEECC
GHVPFFGISNIASTIQKLEKGMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYA
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNMDSVDGKIKERLTKFLNSSANKKY
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHH
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYVHL
HHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VNCKHPLLSGKVVPLNFEIGQNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDK
EECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEECCCC
ETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRMSNNNTLLLFDEIGSGTEPNE
CCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
SGESNALWIANKMNVRERVLKRAKEYMENKEYTLEKVNESKIRKPKFLQEKRENHYEYKI
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCHHHHHHHCCCCEEEE
GDRVNLLDHDDFGIIYKEKDNFYNVVVYYNGEFIEVNVKRITLEVSAKELYPEGYDLNTL
CCEEEEECCCCCEEEEEECCCEEEEEEEECCEEEEEEEEEEEEEEEHHHHCCCCCCCEEE
FVDYKERKMQHDIERGSKKALRKIQKEMRKNRG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTMTFEKLQYNELKDIVKSYCVSGLGKELINKLEPSASIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEECC
GHVPFFGISNIASTIQKLEKGMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYA
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNMDSVDGKIKERLTKFLNSSANKKY
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHH
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYVHL
HHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VNCKHPLLSGKVVPLNFEIGQNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDK
EECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEECCCC
ETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRMSNNNTLLLFDEIGSGTEPNE
CCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
SGESNALWIANKMNVRERVLKRAKEYMENKEYTLEKVNESKIRKPKFLQEKRENHYEYKI
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCHHHHHHHCCCCEEEE
GDRVNLLDHDDFGIIYKEKDNFYNVVVYYNGEFIEVNVKRITLEVSAKELYPEGYDLNTL
CCEEEEECCCCCEEEEEECCCEEEEEEEECCEEEEEEEEEEEEEEEHHHHCCCCCCCEEE
FVDYKERKMQHDIERGSKKALRKIQKEMRKNRG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA