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The map label for this gene is yhcA [H]

Identifier: 222096695

GI number: 222096695

Start: 2988915

End: 2990393

Strand: Reverse

Name: yhcA [H]

Synonym: BCQ_3035

Alternate gene names: 222096695

Gene position: 2990393-2988915 (Counterclockwise)

Preceding gene: 222096697

Following gene: 222096694

Centisome position: 57.35

GC content: 39.35

Gene sequence:

>1479_bases
ATGAGTGAAACGTTACATAAAAGAAAACCACCATATGTAATGCTTGTAATCCTTTTTATTGGGGCATTTGTTTCATTTCT
AAATAACTCGCTTTTAAATGTGGCCTTGCCATCAATAATGAAGGATTTAGAAATTCAAGATTATTCAACGATCCAGTGGC
TTTCTACAGGCTATATGCTTGTAAGTGGTATATTAATTCCGGCATCAGCATTTTTAATAACCCGATTCTCCAATAGGAGC
TTATTCATTACATCTATGGTGATTTTTATTCTTGGTACGGCCTTAGCGGCTATAGCACCGAACTTCGGTTTATTACTTAC
TGGCCGGATGGTGCAAGCAGCAGGTTCTTCAGTGATGGGACCTTTGTTAATGAATATTATGCTAGTAAGCTTTCCGAGAG
AAAAAAGGGGAACGGCAATGGGGATTTTTGGGTTAGTTATGATTACAGCTCCGGCCATTGGACCAACATTATCAGGTTAT
ATTGTAGAGTATTATGACTGGCGTTTGCTTTTTGAAATGATTTTACCGCTAGCAATCATTAGCTTACTGTTAGGGATTTG
GAAATCGGAAAATGTCATGAGACAAAACAAAAATGCAAAACTTGATTATCTCTCATTACTATTATCTTCTGTCGGCTTTG
GCGGTCTGTTATATGGGTTTAGTTCTGCAAGCTCAGATGGGTGGACGAATAAAGTTGTCTTAACAACCTTAATCATAGGC
GCTATTGCCCTAATTGCTTTCATTATCCGTCAATTAAAAATGAATGAACCGTTGTTGGATTTACGTGTTTACAAGTACCC
AATGTTTGCACTTGCGTCTGTAATTGCAATTGTTAATGCGGTGGCTATGTTTTCGGGGATGATTTTAACACCGGCTTATG
TACAAAATGTCCGTGGTATTTCGCCGCTGAGCTCTGGGCTGATGATGCTTCCAGGTGCGGTAATAATGGGAGTTATGTCA
CCCATTACAGGTAAACTATTTGATAAGTATGGCCCTCGGCTTCTTGGTATAGTAGGACTTTCCATTACAGCTGTTTCAAC
TTATATGTTGGCAAATCTGCAACTCGATTCTAGTCACACACATATTATCCTTATTTACACATTGCGGATGTTTGGGATGG
CGATGGTGATGATGCCACTTATGACAAATGGCCTTAATCAATTGCCAACTCGCTTAAATCCGCACGGTACAGCTGTTAAT
AATACAGCTCAACAAGTGTCCGGTTCAATTGGTACTGCTATTCTTGTTACGATTATGAATTCTGTAACAAAAACAAAAGC
TGAAAGTTTAATGGCTCATGTAGATCCAACAACCTTCACAGAAGCTACGAAGGCAATGGTAACGCAGAAGGCTTTGTTAT
CCGGAATTCAGCATTCATTCTATGTAGCGCTTGGCATGAATGTTGTTGCGCTACTATTAGTTTTTTTCGTTAAACGTGTA
GATACAAGCGCGGAAGCTGTCGAGAGGTTAAATCGATAG

Upstream 100 bases:

>100_bases
AGAGTTTGGCAAAATACTGCAAGGGTAATAAATTCTCGTGCAAATATGCAAACGAGTTAAATTAATCAATGGAATTGATA
ATGAAGGGGCAAATAAATAT

Downstream 100 bases:

>100_bases
AGCAAAATAAAACTCGAGATGATGATTTCTACTAAAAGGGGAAAAGAGATGAAAGAAAAAGTGAAATAATTACACAGAAT
GAAAAAGGATTTGATATGAA

Product: multidrug resistance protein b

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLEIQDYSTIQWLSTGYMLVSGILIPASAFLITRFSNRS
LFITSMVIFILGTALAAIAPNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSGY
IVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSVGFGGLLYGFSSASSDGWTNKVVLTTLIIG
AIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRGISPLSSGLMMLPGAVIMGVMS
PITGKLFDKYGPRLLGIVGLSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAVN
NTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTTFTEATKAMVTQKALLSGIQHSFYVALGMNVVALLLVFFVKRV
DTSAEAVERLNR

Sequences:

>Translated_492_residues
MSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLEIQDYSTIQWLSTGYMLVSGILIPASAFLITRFSNRS
LFITSMVIFILGTALAAIAPNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSGY
IVEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSVGFGGLLYGFSSASSDGWTNKVVLTTLIIG
AIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRGISPLSSGLMMLPGAVIMGVMS
PITGKLFDKYGPRLLGIVGLSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAVN
NTAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTTFTEATKAMVTQKALLSGIQHSFYVALGMNVVALLLVFFVKRV
DTSAEAVERLNR
>Mature_491_residues
SETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLEIQDYSTIQWLSTGYMLVSGILIPASAFLITRFSNRSL
FITSMVIFILGTALAAIAPNFGLLLTGRMVQAAGSSVMGPLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSGYI
VEYYDWRLLFEMILPLAIISLLLGIWKSENVMRQNKNAKLDYLSLLLSSVGFGGLLYGFSSASSDGWTNKVVLTTLIIGA
IALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRGISPLSSGLMMLPGAVIMGVMSP
ITGKLFDKYGPRLLGIVGLSITAVSTYMLANLQLDSSHTHIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAVNN
TAQQVSGSIGTAILVTIMNSVTKTKAESLMAHVDPTTFTEATKAMVTQKALLSGIQHSFYVALGMNVVALLLVFFVKRVD
TSAEAVERLNR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=451, Percent_Identity=26.3858093126386, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789042, Length=489, Percent_Identity=23.5173824130879, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87081983, Length=410, Percent_Identity=26.5853658536585, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790195, Length=396, Percent_Identity=26.010101010101, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788392, Length=405, Percent_Identity=26.1728395061728, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322958, Length=455, Percent_Identity=23.5164835164835, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=328, Percent_Identity=23.780487804878, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=239, Percent_Identity=23.4309623430962, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53491; Mature: 53360

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLEIQDYSTIQWLSTGYML
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VSGILIPASAFLITRFSNRSLFITSMVIFILGTALAAIAPNFGLLLTGRMVQAAGSSVMG
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHCCCHHHH
PLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSGYIVEYYDWRLLFEMILPLAII
HHHHHHHHHHCCCHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLLLGIWKSENVMRQNKNAKLDYLSLLLSSVGFGGLLYGFSSASSDGWTNKVVLTTLIIG
HHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
AIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRGI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHCCCC
SPLSSGLMMLPGAVIMGVMSPITGKLFDKYGPRLLGIVGLSITAVSTYMLANLQLDSSHT
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCC
HIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAVNNTAQQVSGSIGTAILVTIMN
EEEHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
SVTKTKAESLMAHVDPTTFTEATKAMVTQKALLSGIQHSFYVALGMNVVALLLVFFVKRV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DTSAEAVERLNR
CCHHHHHHHHCC
>Mature Secondary Structure 
SETLHKRKPPYVMLVILFIGAFVSFLNNSLLNVALPSIMKDLEIQDYSTIQWLSTGYML
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VSGILIPASAFLITRFSNRSLFITSMVIFILGTALAAIAPNFGLLLTGRMVQAAGSSVMG
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHCCCHHHH
PLLMNIMLVSFPREKRGTAMGIFGLVMITAPAIGPTLSGYIVEYYDWRLLFEMILPLAII
HHHHHHHHHHCCCHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLLLGIWKSENVMRQNKNAKLDYLSLLLSSVGFGGLLYGFSSASSDGWTNKVVLTTLIIG
HHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
AIALIAFIIRQLKMNEPLLDLRVYKYPMFALASVIAIVNAVAMFSGMILTPAYVQNVRGI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHCCCC
SPLSSGLMMLPGAVIMGVMSPITGKLFDKYGPRLLGIVGLSITAVSTYMLANLQLDSSHT
CHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCC
HIILIYTLRMFGMAMVMMPLMTNGLNQLPTRLNPHGTAVNNTAQQVSGSIGTAILVTIMN
EEEHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
SVTKTKAESLMAHVDPTTFTEATKAMVTQKALLSGIQHSFYVALGMNVVALLLVFFVKRV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DTSAEAVERLNR
CCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]