Click here to switch to the map view.

The map label for this gene is ccpA [H]

Identifier: 222096664

GI number: 222096664

Start: 2953370

End: 2954380

Strand: Reverse

Name: ccpA [H]

Synonym: BCQ_3004

Alternate gene names: 222096664

Gene position: 2954380-2953370 (Counterclockwise)

Preceding gene: 222096665

Following gene: 222096663

Centisome position: 56.66

GC content: 36.8

Gene sequence:

>1011_bases
ATGGCTAAGTCTACAATTAAAGATGTTGCATTGGAAGCGAATGTGTCTACAGCTACAGTATCTCGTGTGTTAAACGAAAG
TGGATTTGTAAGTGACGACATTAAAGATCGTGTTCATTTAGCTGTGAAAAAATTGAATTATCAACCAAATGCGATTGCTA
GAAGTTTAAAGCAAGATAAAACATACACGATTGGTGTTGTGATTCCGGATATTACAAACCATTATTACATGACAATTTCA
AAGGCGATTGAAGATATTGTACAGCAAAAGGGCTATAACCTTATTTTCTGTAGCAGTCATGAAAATCCTAAAAAAGAGGA
TAAATTGTTGCAACTATTAGTGGAACAGCGGGTGGATGCGATTGTATTGGCTACTGCTGGAGGTTGTGAAGAAAGAGTGA
GAAGTATTCATCAAGCTGGTGTACCAATCGTTTTAGTTGATCGGACTGTTGAGATTGGAGATTCAAAATTAGATTCGGTT
GTAGAAAGTAATTTTGAAAGTGCTTATACATTAACGAGCTATCTTTTACAACAGGGGCATCGGTCGATTGGTCTTGTAAA
TGGATTGTTAAACGTTAGTACAGGTAAAGAGCGCTATGAAGGATTTCAGAAAGCTTTAGAAGAGTTTGGGATTCAAGAAG
ATGAAAACTATACGTTTAATAGCACTTTCACAAGAGAAGGTGGTATGAAAGCAGTTGATTATTTTCTTAATTTCACTGAG
AAACCGTCAGCTATTCTATCTTTGAACAATGAAATGGCATTTGGTGTTCTTCTTGAATTAACGAGGAGAGGCTACTCTGT
ACCAGAGGACATCGTGATCGCTTCTTTTGGTGATGTGGAAGCCGCACAATTATTACAAGCGCCTGGGATTATATCAGTCG
CTCACAAACCATATGAAATGGGAGAAAGGGTAGGCGATATATTACTGAAACGCTTAAATAATGAAGAAGGTCCCTTTCAT
GAAATATTTACACCAAAGTTATTAATAGATGCACAAAGTGTAAGTAGTTGA

Upstream 100 bases:

>100_bases
TATCCATGTAAACTACTAAGTAATCGTTTACATGGATGAAATAAGGGTTTAAACAAAACTGAAGTAAACGATTTCTTGAA
AATTTAGAAAGAGTGATGAA

Downstream 100 bases:

>100_bases
AACGTATTTTCGTTAAGATAAAAATCGGAAGGGAGATAGAAATGCTAAAAGGAATACCGAAAATAATTAGTCCGGATTTA
ATGAAAGTTCTTTTAGAAAT

Product: transcriptional regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKSTIKDVALEANVSTATVSRVLNESGFVSDDIKDRVHLAVKKLNYQPNAIARSLKQDKTYTIGVVIPDITNHYYMTIS
KAIEDIVQQKGYNLIFCSSHENPKKEDKLLQLLVEQRVDAIVLATAGGCEERVRSIHQAGVPIVLVDRTVEIGDSKLDSV
VESNFESAYTLTSYLLQQGHRSIGLVNGLLNVSTGKERYEGFQKALEEFGIQEDENYTFNSTFTREGGMKAVDYFLNFTE
KPSAILSLNNEMAFGVLLELTRRGYSVPEDIVIASFGDVEAAQLLQAPGIISVAHKPYEMGERVGDILLKRLNNEEGPFH
EIFTPKLLIDAQSVSS

Sequences:

>Translated_336_residues
MAKSTIKDVALEANVSTATVSRVLNESGFVSDDIKDRVHLAVKKLNYQPNAIARSLKQDKTYTIGVVIPDITNHYYMTIS
KAIEDIVQQKGYNLIFCSSHENPKKEDKLLQLLVEQRVDAIVLATAGGCEERVRSIHQAGVPIVLVDRTVEIGDSKLDSV
VESNFESAYTLTSYLLQQGHRSIGLVNGLLNVSTGKERYEGFQKALEEFGIQEDENYTFNSTFTREGGMKAVDYFLNFTE
KPSAILSLNNEMAFGVLLELTRRGYSVPEDIVIASFGDVEAAQLLQAPGIISVAHKPYEMGERVGDILLKRLNNEEGPFH
EIFTPKLLIDAQSVSS
>Mature_335_residues
AKSTIKDVALEANVSTATVSRVLNESGFVSDDIKDRVHLAVKKLNYQPNAIARSLKQDKTYTIGVVIPDITNHYYMTISK
AIEDIVQQKGYNLIFCSSHENPKKEDKLLQLLVEQRVDAIVLATAGGCEERVRSIHQAGVPIVLVDRTVEIGDSKLDSVV
ESNFESAYTLTSYLLQQGHRSIGLVNGLLNVSTGKERYEGFQKALEEFGIQEDENYTFNSTFTREGGMKAVDYFLNFTEK
PSAILSLNNEMAFGVLLELTRRGYSVPEDIVIASFGDVEAAQLLQAPGIISVAHKPYEMGERVGDILLKRLNNEEGPFHE
IFTPKLLIDAQSVSS

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=337, Percent_Identity=32.9376854599407, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1790194, Length=317, Percent_Identity=33.4384858044164, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790369, Length=318, Percent_Identity=30.8176100628931, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1789068, Length=328, Percent_Identity=29.5731707317073, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=29.0419161676647, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786268, Length=317, Percent_Identity=28.7066246056782, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788474, Length=325, Percent_Identity=28.9230769230769, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1787906, Length=341, Percent_Identity=25.5131964809384, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=24.2990654205607, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI48994940, Length=339, Percent_Identity=25.9587020648968, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=22.5396825396825, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1786540, Length=297, Percent_Identity=26.9360269360269, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789456, Length=301, Percent_Identity=23.9202657807309, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790192, Length=225, Percent_Identity=24, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790689, Length=200, Percent_Identity=26.5, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37252; Mature: 37121

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSTIKDVALEANVSTATVSRVLNESGFVSDDIKDRVHLAVKKLNYQPNAIARSLKQDK
CCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TYTIGVVIPDITNHYYMTISKAIEDIVQQKGYNLIFCSSHENPKKEDKLLQLLVEQRVDA
CEEEEEEECCCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCE
IVLATAGGCEERVRSIHQAGVPIVLVDRTVEIGDSKLDSVVESNFESAYTLTSYLLQQGH
EEEEECCCHHHHHHHHHHCCCCEEEECCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCC
RSIGLVNGLLNVSTGKERYEGFQKALEEFGIQEDENYTFNSTFTREGGMKAVDYFLNFTE
CHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCEECCCCCHHHHHHHHCCCC
KPSAILSLNNEMAFGVLLELTRRGYSVPEDIVIASFGDVEAAQLLQAPGIISVAHKPYEM
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCEEEECCCCHHH
GERVGDILLKRLNNEEGPFHEIFTPKLLIDAQSVSS
HHHHHHHHHHHHCCCCCCCHHHCCCEEEEECHHCCC
>Mature Secondary Structure 
AKSTIKDVALEANVSTATVSRVLNESGFVSDDIKDRVHLAVKKLNYQPNAIARSLKQDK
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
TYTIGVVIPDITNHYYMTISKAIEDIVQQKGYNLIFCSSHENPKKEDKLLQLLVEQRVDA
CEEEEEEECCCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCE
IVLATAGGCEERVRSIHQAGVPIVLVDRTVEIGDSKLDSVVESNFESAYTLTSYLLQQGH
EEEEECCCHHHHHHHHHHCCCCEEEECCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCC
RSIGLVNGLLNVSTGKERYEGFQKALEEFGIQEDENYTFNSTFTREGGMKAVDYFLNFTE
CHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCEECCCCCHHHHHHHHCCCC
KPSAILSLNNEMAFGVLLELTRRGYSVPEDIVIASFGDVEAAQLLQAPGIISVAHKPYEM
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCEEEECCCCHHH
GERVGDILLKRLNNEEGPFHEIFTPKLLIDAQSVSS
HHHHHHHHHHHHCCCCCCCHHHCCCEEEEECHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA