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The map label for this gene is mutX [H]

Identifier: 222096555

GI number: 222096555

Start: 2830469

End: 2830999

Strand: Reverse

Name: mutX [H]

Synonym: BCQ_2895

Alternate gene names: 222096555

Gene position: 2830999-2830469 (Counterclockwise)

Preceding gene: 222096557

Following gene: 222096554

Centisome position: 54.29

GC content: 33.15

Gene sequence:

>531_bases
ATGTATAAGTACACAATTTGTTTCATTAGAAAAGGAAATAAAATACTCTTATTGAATAGAAATAAAAAGCCAAATATGGG
AATGTGGAATGGTGTTGGTGGAAAAATTGAAGATAATGAAACGCCATATGAAGGGATAATTAGAGAAACGCTTGAAGAAA
CAGGCATAGATCTTCCAAGTGTAACGTATAAGGGGAATGTCGTTTTTAAAAGTAAGGACGAGTCTCAGGGGCGTGAAGGA
ATGTATGTATTCCTTGCTGACCTGCCAGATGGAGTACATATGGACACGCCATTAAGTACGACGGAAGGATTATTAGAATG
GAAAGAAATTGATTGGATATTAAATAAGGATAATAGAGGTGTAGTTACCAATTTACTAAAATACTTACCAATAGTATTAA
CAGAAGAAAATAAGTTAGAGCATATATTCACATATGATAACGGGAATATTATTACTTACACAACTTCATATTTGACAGAA
GATGATGCGAACAAACGGCATGTAAAAAAAACTCTCTCATACTCAAGTTAA

Upstream 100 bases:

>100_bases
AAACCAGTTGTTTGTATAATAAGAATTTTTTTATGCAGCAAGTCTAATCAAAATGCTGTTTAAATTTTTAGATGAGGGGA
AAAAGAAAGGAAAGAAACGT

Downstream 100 bases:

>100_bases
TAAAATATTTCAAAGAGCAATCAGCATTTTTATGTTGATTGCTCTCATTATATATAAGGGGGAAAGATATGTTTCAGAAA
TACAATTCATTGACCATAAT

Product: phosphohydrolase, mutt/nudix family

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPSVTYKGNVVFKSKDESQGREG
MYVFLADLPDGVHMDTPLSTTEGLLEWKEIDWILNKDNRGVVTNLLKYLPIVLTEENKLEHIFTYDNGNIITYTTSYLTE
DDANKRHVKKTLSYSS

Sequences:

>Translated_176_residues
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPSVTYKGNVVFKSKDESQGREG
MYVFLADLPDGVHMDTPLSTTEGLLEWKEIDWILNKDNRGVVTNLLKYLPIVLTEENKLEHIFTYDNGNIITYTTSYLTE
DDANKRHVKKTLSYSS
>Mature_176_residues
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPSVTYKGNVVFKSKDESQGREG
MYVFLADLPDGVHMDTPLSTTEGLLEWKEIDWILNKDNRGVVTNLLKYLPIVLTEENKLEHIFTYDNGNIITYTTSYLTE
DDANKRHVKKTLSYSS

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 20221; Mature: 20221

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPS
CCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCC
VTYKGNVVFKSKDESQGREGMYVFLADLPDGVHMDTPLSTTEGLLEWKEIDWILNKDNRG
EEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHEEEEEEEEEECCCCC
VVTNLLKYLPIVLTEENKLEHIFTYDNGNIITYTTSYLTEDDANKRHVKKTLSYSS
HHHHHHHHCCEEEECCCCEEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIRETLEETGIDLPS
CCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCC
VTYKGNVVFKSKDESQGREGMYVFLADLPDGVHMDTPLSTTEGLLEWKEIDWILNKDNRG
EEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHEEEEEEEEEECCCCC
VVTNLLKYLPIVLTEENKLEHIFTYDNGNIITYTTSYLTEDDANKRHVKKTLSYSS
HHHHHHHHCCEEEECCCCEEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]