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The map label for this gene is ipdC [H]

Identifier: 222096064

GI number: 222096064

Start: 2366790

End: 2368475

Strand: Reverse

Name: ipdC [H]

Synonym: BCQ_2404

Alternate gene names: 222096064

Gene position: 2368475-2366790 (Counterclockwise)

Preceding gene: 222096071

Following gene: 222096056

Centisome position: 45.42

GC content: 35.35

Gene sequence:

>1686_bases
ATGATTCACTTGAAAACGCAATATACTGTTAGTACTTATTTATTAGACCGACTAAGCGAATTAGGAATTGAACATATTTT
TGGTGTCCCTGGTGATTATAATTTGGCTTTTTTAGATGATGTAATAGCACATGAAAATGTAGAGTGGATTGGCAATTGTA
ATGAATTAAATGCGGCATATGCTGCTGATGGATATGCTCGTATAAAAGGAATCGCTGCTCTTATTACCACTTTCGGTGTT
GGAGAATTAAGCGCCATTAACGGTATTGCTGGATCATATGCCGAAAATGTACCTGTTATAAAAATTACGGGGACACCACC
AACAACAGTAATGGAAAATGGAGCACTCGTTCATCATACGTTAGGTGATGGAAAGTTCGATCATTTTTCTAATATGTATA
GAGAAATCACGGTGGCACAATCAAAATTAACACCTGAGCATGCCGCTGAAGAAATTGACCGTGTGTTACGTGCATGTTGG
AGTGCGAAACGCCCTGTTCATATTCAATTACCGATTGATGTGTATAATAAACCAATTAATAAACCTACGGAACCGATTTT
ACATAAACCAGTTGTAAGTAATAAAGATGCGCTGGATAAAATGCTTCTACATGCCACTTCAAAAATAAACAGTGCCAAAA
AACCTGTAATTTTAGCGGATTTTGAAGTAGAACGATTTCACGCTAAAGAATATTTATATCAATTCGTAGAAAAAACTGGG
TTTCCCATCGCAACGTTAAGTATGGGAAAAGGAATATTCCCAGAAAAACACCCTCAATTTATAGGGATTTATACTGGTGA
TGTAAGTTCTCCATACTTGCGTAAACGAATTGATGAATCTGATTGTATTATTAGTATTGGTGTGAAGTTAACTGATACTA
TTACAGGTGGCTTCACACAAGGTTTTATGAAAGAACAAGTTATTGAAATTCATCCCTACACTGTGAAAATTACAGATAAA
AAATATGGACCAGTTGTAATGAAAGATGTTTTACAACATTTAAGTGACTTAATTGAGCATCGCAATGGGGAAACGCTTGA
TATTAAGCCATTTATTTCAGAATCACTATCTATTACTGAAAAGTTTAATCCAAAGCCACAAATGGTTACACAAAAACGTT
TTTGTCAACAAATATACCATTTCTTACAAGAAAAGGACGTCTTACTTGCAGAACAAGGAACACCTTTCTTTGGTAGTGCC
ACTATCCCTTTACCAAACGACACTACATATGTAGCGCAACCATTATGGGGATCGATCGGCTATACATTACCTGCTCTACT
TGGTACACAGCTCGCTAATTTATCGCGGCGCAACATTTTAATTATTGGTGATGGTTCTTTTCAATTAACTGTCCAAGAAT
TATCAACTATACTACGTCAAAATTTAAACCCAATTATATTTTTAATTAACAACAATGGTTATACTGTTGAACGTGCAATT
CATGGTCAAAACGAACCGTATAATGACATACAAATGTGGGATTACACAAAACTAGCGAACGTATTCGGAACAGAAGAAAA
AAGCCTAACATGTAAAGTGGAAAATGAAATAGAGTTACAAGAAGTCTTAACTAAAATAAGTAATGATAAGGATCAACTTA
CCTTTGTTGAAGTTGTAATGAGCCAAGGGGATCAGCCTGAACTGCTAGCTAAACTTGGGAAAAGATTCGGCCAACAAAAT
TCTTAA

Upstream 100 bases:

>100_bases
TCCCCCTGTATGTAAATTATACCACATTCTCGTAATGAATTTTTAAATCCATACTCTAGAGCTACTTTCGTTTATTACAA
GACAGCAAAACAATGAGGAG

Downstream 100 bases:

>100_bases
TATAAAAAGCATAACCTAATTATATAAAAAGAAAAGGATGGAAAGTGCCACCCTTTTCCTTTTATATATACTATTTTAAG
AACCTTCTTCGACTAAAGTC

Product: indolepyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVIAHENVEWIGNCNELNAAYAADGYARIKGIAALITTFGV
GELSAINGIAGSYAENVPVIKITGTPPTTVMENGALVHHTLGDGKFDHFSNMYREITVAQSKLTPEHAAEEIDRVLRACW
SAKRPVHIQLPIDVYNKPINKPTEPILHKPVVSNKDALDKMLLHATSKINSAKKPVILADFEVERFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFMKEQVIEIHPYTVKITDK
KYGPVVMKDVLQHLSDLIEHRNGETLDIKPFISESLSITEKFNPKPQMVTQKRFCQQIYHFLQEKDVLLAEQGTPFFGSA
TIPLPNDTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLNPIIFLINNNGYTVERAI
HGQNEPYNDIQMWDYTKLANVFGTEEKSLTCKVENEIELQEVLTKISNDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQN
S

Sequences:

>Translated_561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVIAHENVEWIGNCNELNAAYAADGYARIKGIAALITTFGV
GELSAINGIAGSYAENVPVIKITGTPPTTVMENGALVHHTLGDGKFDHFSNMYREITVAQSKLTPEHAAEEIDRVLRACW
SAKRPVHIQLPIDVYNKPINKPTEPILHKPVVSNKDALDKMLLHATSKINSAKKPVILADFEVERFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFMKEQVIEIHPYTVKITDK
KYGPVVMKDVLQHLSDLIEHRNGETLDIKPFISESLSITEKFNPKPQMVTQKRFCQQIYHFLQEKDVLLAEQGTPFFGSA
TIPLPNDTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLNPIIFLINNNGYTVERAI
HGQNEPYNDIQMWDYTKLANVFGTEEKSLTCKVENEIELQEVLTKISNDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQN
S
>Mature_561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVIAHENVEWIGNCNELNAAYAADGYARIKGIAALITTFGV
GELSAINGIAGSYAENVPVIKITGTPPTTVMENGALVHHTLGDGKFDHFSNMYREITVAQSKLTPEHAAEEIDRVLRACW
SAKRPVHIQLPIDVYNKPINKPTEPILHKPVVSNKDALDKMLLHATSKINSAKKPVILADFEVERFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQGFMKEQVIEIHPYTVKITDK
KYGPVVMKDVLQHLSDLIEHRNGETLDIKPFISESLSITEKFNPKPQMVTQKRFCQQIYHFLQEKDVLLAEQGTPFFGSA
TIPLPNDTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLNPIIFLINNNGYTVERAI
HGQNEPYNDIQMWDYTKLANVFGTEEKSLTCKVENEIELQEVLTKISNDKDQLTFVEVVMSQGDQPELLAKLGKRFGQQN
S

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=555, Percent_Identity=23.7837837837838, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1790104, Length=554, Percent_Identity=22.5631768953069, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786717, Length=482, Percent_Identity=24.2738589211618, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=22.5225225225225, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788716, Length=476, Percent_Identity=21.218487394958, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531299, Length=488, Percent_Identity=25.6147540983607, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531301, Length=488, Percent_Identity=25.6147540983607, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=571, Percent_Identity=38.7040280210158, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323073, Length=571, Percent_Identity=38.1786339754816, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321524, Length=577, Percent_Identity=37.0883882149047, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6320123, Length=562, Percent_Identity=35.5871886120996, Blast_Score=350, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6320588, Length=596, Percent_Identity=30.5369127516779, Blast_Score=270, Evalue=5e-73,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 62823; Mature: 62823

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVIAHENVEWIGNCNELNAAY
CEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHH
AADGYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTTVMENGALVHHT
HCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCCCEECCCCEEEEE
LGDGKFDHFSNMYREITVAQSKLTPEHAAEEIDRVLRACWSAKRPVHIQLPIDVYNKPIN
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCC
KPTEPILHKPVVSNKDALDKMLLHATSKINSAKKPVILADFEVERFHAKEYLYQFVEKTG
CCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCC
FPIATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQ
CCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEECCCCHHH
GFMKEQVIEIHPYTVKITDKKYGPVVMKDVLQHLSDLIEHRNGETLDIKPFISESLSITE
HHHHHCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCHHH
KFNPKPQMVTQKRFCQQIYHFLQEKDVLLAEQGTPFFGSATIPLPNDTTYVAQPLWGSIG
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCHHHHH
YTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLNPIIFLINNNGYTVERAI
HHHHHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEE
HGQNEPYNDIQMWDYTKLANVFGTEEKSLTCKVENEIELQEVLTKISNDKDQLTFVEVVM
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHH
SQGDQPELLAKLGKRFGQQNS
HCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIHLKTQYTVSTYLLDRLSELGIEHIFGVPGDYNLAFLDDVIAHENVEWIGNCNELNAAY
CEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHH
AADGYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTTVMENGALVHHT
HCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCCCEECCCCEEEEE
LGDGKFDHFSNMYREITVAQSKLTPEHAAEEIDRVLRACWSAKRPVHIQLPIDVYNKPIN
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCC
KPTEPILHKPVVSNKDALDKMLLHATSKINSAKKPVILADFEVERFHAKEYLYQFVEKTG
CCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCC
FPIATLSMGKGIFPEKHPQFIGIYTGDVSSPYLRKRIDESDCIISIGVKLTDTITGGFTQ
CCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEECCCCHHH
GFMKEQVIEIHPYTVKITDKKYGPVVMKDVLQHLSDLIEHRNGETLDIKPFISESLSITE
HHHHHCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCHHH
KFNPKPQMVTQKRFCQQIYHFLQEKDVLLAEQGTPFFGSATIPLPNDTTYVAQPLWGSIG
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCHHHHH
YTLPALLGTQLANLSRRNILIIGDGSFQLTVQELSTILRQNLNPIIFLINNNGYTVERAI
HHHHHHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCEEEEEECCCCEEEEEEE
HGQNEPYNDIQMWDYTKLANVFGTEEKSLTCKVENEIELQEVLTKISNDKDQLTFVEVVM
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHH
SQGDQPELLAKLGKRFGQQNS
HCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]