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The map label for this gene is gmhB [H]

Identifier: 222095824

GI number: 222095824

Start: 2139967

End: 2140494

Strand: Reverse

Name: gmhB [H]

Synonym: BCQ_2164

Alternate gene names: 222095824

Gene position: 2140494-2139967 (Counterclockwise)

Preceding gene: 222095825

Following gene: 222095817

Centisome position: 41.05

GC content: 39.02

Gene sequence:

>528_bases
ATGACAAACATTCAAGCAATTTTCATTGATCGTGACGGTACAATTGGTGGCGATACTACCATACATTACCCAGGATCCTT
TACATTATTCCCTTTTACAAAAGTAGCTCTACAAAAACTAAAAGCTAATCATATAAAAATTTTCTCTTTTACAAACCAGC
CAGGTATCGCGGATGGGATAGCAACTGTAGCCGATTTTGTACAAGAATTAGAAGGCTTCGGTTTTGATGATATTTATGTA
TGTCCTCATAAACACGGTGATGGTTGCGAATGTCGTAAACCAAATACAGGCATGCTGCTACAAGCAGCTGAAAAACACGG
GCTTGATTTAACACAATGTGCTGTAATTGGTGATCGCTGGACTGATATCGTTGCAGGAGCAAAAGTGAATGCGACAACAA
TTTTAGTACGAACAGGCGCTGGATACGACGCTTTACATACGTACCGAGACAAGTGGGCACATATTGAACCAAACTACATT
GCAGAAAACTTTGAAGATGCGACAAATTGGGTTTTAAATCAACTATAA

Upstream 100 bases:

>100_bases
TAGAAGCTCATCCTTTTTACAAAAAATTAGGATATGAAGTGAATGGATATCGATTTGTAAAACATTTTTAAACTACTTGT
TAATTGAAAGGACTATAACT

Downstream 100 bases:

>100_bases
TACAAATGAAAAGAGACGCCTTCAAAATGAAAGCGCCTCTTTTCATCTAATATTATTTAAAACGTTAATTCATAATGGAA
ATAACGATTATCTCTCAAAT

Product: hypothetical protein

Products: L-histidinol; phosphate

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MTNIQAIFIDRDGTIGGDTTIHYPGSFTLFPFTKVALQKLKANHIKIFSFTNQPGIADGIATVADFVQELEGFGFDDIYV
CPHKHGDGCECRKPNTGMLLQAAEKHGLDLTQCAVIGDRWTDIVAGAKVNATTILVRTGAGYDALHTYRDKWAHIEPNYI
AENFEDATNWVLNQL

Sequences:

>Translated_175_residues
MTNIQAIFIDRDGTIGGDTTIHYPGSFTLFPFTKVALQKLKANHIKIFSFTNQPGIADGIATVADFVQELEGFGFDDIYV
CPHKHGDGCECRKPNTGMLLQAAEKHGLDLTQCAVIGDRWTDIVAGAKVNATTILVRTGAGYDALHTYRDKWAHIEPNYI
AENFEDATNWVLNQL
>Mature_174_residues
TNIQAIFIDRDGTIGGDTTIHYPGSFTLFPFTKVALQKLKANHIKIFSFTNQPGIADGIATVADFVQELEGFGFDDIYVC
PHKHGDGCECRKPNTGMLLQAAEKHGLDLTQCAVIGDRWTDIVAGAKVNATTILVRTGAGYDALHTYRDKWAHIEPNYIA
ENFEDATNWVLNQL

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=192, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: 3.1.3.15

Molecular weight: Translated: 19316; Mature: 19185

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIQAIFIDRDGTIGGDTTIHYPGSFTLFPFTKVALQKLKANHIKIFSFTNQPGIADGI
CCCEEEEEEECCCCCCCCCEEEECCCEEECHHHHHHHHHHCCCEEEEEEECCCCCCHHHH
ATVADFVQELEGFGFDDIYVCPHKHGDGCECRKPNTGMLLQAAEKHGLDLTQCAVIGDRW
HHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEHHHCCCCHHHHEEECCCH
TDIVAGAKVNATTILVRTGAGYDALHTYRDKWAHIEPNYIAENFEDATNWVLNQL
HHHHCCCEECEEEEEEEECCCCHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHCC
>Mature Secondary Structure 
TNIQAIFIDRDGTIGGDTTIHYPGSFTLFPFTKVALQKLKANHIKIFSFTNQPGIADGI
CCEEEEEEECCCCCCCCCEEEECCCEEECHHHHHHHHHHCCCEEEEEEECCCCCCHHHH
ATVADFVQELEGFGFDDIYVCPHKHGDGCECRKPNTGMLLQAAEKHGLDLTQCAVIGDRW
HHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEHHHCCCCHHHHEEECCCH
TDIVAGAKVNATTILVRTGAGYDALHTYRDKWAHIEPNYIAENFEDATNWVLNQL
HHHHCCCEECEEEEEEEECCCCHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; H2O

Specific reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430; 12101286 [H]