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The map label for this gene is moeA [H]

Identifier: 222095769

GI number: 222095769

Start: 2080956

End: 2082245

Strand: Direct

Name: moeA [H]

Synonym: BCQ_2109

Alternate gene names: 222095769

Gene position: 2080956-2082245 (Clockwise)

Preceding gene: 222095768

Following gene: 222095770

Centisome position: 39.91

GC content: 39.53

Gene sequence:

>1290_bases
ATGTTAGAAAAACGTATACCGATTCCAGTGGCAGAAGCAGTTGCACGAGTAATGAAATATGCTCATCAAGGTGAAACAGA
AGAGGTTTCTCTTATAGAAAGTTACGGTAGAACGCTTGGAGAAGATGTTATTGCAGATCATGATGTCCCACATTTTGATC
GCTCTCCGTACGACGGATTTGCGATTCGAGCGGAAGACACAAAAGAAGCAAGTAGCAGTAATCCCATTCAGTTTGAAGTG
ATTGGTGAAATTGGAGCAGGGGTTGTTTTTACAGAAGAAGTGAAAGCATTTCAAGCTGTCCGTATTATGACAGGGGCCGC
AATTCCGAGAGGGTGTAATGCGGTTGTGATGTTGGAGATAACGGAAGGGTTTGAAGAAAACGAAAAGACTTATATGACAT
TAAAACGCTGTTTCGCAGCCGGTGATAACATTTCTTTTAAAGGAGAAGATGTAAAACAAAATAGCACCCTTGTGAAAAAA
GGGACTGTTATTAATCCTGGAGTTGCAGCACTTCTTGCTACGTTTGGTTATAGTTCCGTACATGTTGTAAAACAGCCGAT
TATTGGAATTGTAACGACGGGTAGTGAACTGCTTGAAGTACATGAACAATTAAAGCCAGGGAAGATTCGAAATAGTAACT
CCTATATGATAGCTGCGCAAATTGAACGAGCGGGCGGAGTTGTACGGTATTATGGACAATTCGTTGACGATTTTGAGACG
TGTTATAACAATGTAAAAAAGGCGATAAAAGAAGTTGATATTTTAATTACGACTGGTGGCGTTTCAGTAGGAGACTATGA
CTATTTGCCTGCTATTTATGAGAGATTACAAGCTAATGTACTTTTTAACAAAATAGCGATGCGACCAGGAAGTGTGACAA
CTGTAGCTGAGGTAGAAGGAAAACTACTATTTGGTTTATCTGGTAATCCTTCAGCTTGTTATGTCGGTTGTGAATTATAT
GTTAGACCAGTCATTGGAACATACTTGCATAGAAAAGATTCGCACGTATTTCGTGCAGAGGCAATTTTACAAAAAGACTT
TCCGAAAGCAAATCCGTTTACTCGATTTGTAAGAGGGAGAGTAGAAATTGTAGATGGTCAATTGCAAGTTACACCAGTTG
GTTTAGATAAATCTAGCGCAATTTCTTCACTTGCAGAAGCGAATGCATTTATTGTTTTGCCAGGGGGAACGAGAGGATTT
AAAGCTGGAATTACTGTTTCGGTACTGTTATTAGAATTAACCAGCGGAAGTGAATGGCCATGGAAAGAATCGCTTCGTTC
ATACAAATAA

Upstream 100 bases:

>100_bases
GTTCATGGGACAAATGATGTGAAAATGGCAAAACGACTATATGCAAAATATATAGGATGAACAGAGAGAGTTTCTCCTTA
TTAAAACGAGGTGAAAAAGA

Downstream 100 bases:

>100_bases
TAGAAAAATAGGTTGCTAATTTATACAAAGATAAGAGGTGCGAAATGACACATACGTATTATGAAGTAATTGATACACCT
ATATCAATTGAAGAAGTGAC

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLEKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEITEGFEENEKTYMTLKRCFAAGDNISFKGEDVKQNSTLVKK
GTVINPGVAALLATFGYSSVHVVKQPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGRVEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLELTSGSEWPWKESLRSYK

Sequences:

>Translated_429_residues
MLEKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEITEGFEENEKTYMTLKRCFAAGDNISFKGEDVKQNSTLVKK
GTVINPGVAALLATFGYSSVHVVKQPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGRVEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLELTSGSEWPWKESLRSYK
>Mature_429_residues
MLEKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEITEGFEENEKTYMTLKRCFAAGDNISFKGEDVKQNSTLVKK
GTVINPGVAALLATFGYSSVHVVKQPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGRVEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLELTSGSEWPWKESLRSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=392, Percent_Identity=33.6734693877551, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI66932975, Length=392, Percent_Identity=33.6734693877551, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=30.7291666666667, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI25147659, Length=365, Percent_Identity=29.8630136986301, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=367, Percent_Identity=25.3405994550409, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136978, Length=363, Percent_Identity=27.5482093663912, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24638841, Length=363, Percent_Identity=27.5482093663912, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46904; Mature: 46904

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00028 ZINC_FINGER_C2H2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASSSNPIQFEVIGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEI
EEEECCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEGFEENEKTYMTLKRCFAAGDNISFKGEDVKQNSTLVKKGTVINPGVAALLATFGYSSV
ECCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCEEEECCCEECCHHHHHHHHHCCCHH
HVVKQPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
EEECCCCEEEEECCHHHHHHHHHCCCCCEECCCCEEEEEEEHHCCCCHHHHHHHHHHHHH
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGCELYVRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGR
EEEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHCCE
VEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGFKAGITVSVLLLELTSGSEWP
EEEEECEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCCC
WKESLRSYK
HHHHHHCCC
>Mature Secondary Structure
MLEKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASSSNPIQFEVIGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEI
EEEECCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEGFEENEKTYMTLKRCFAAGDNISFKGEDVKQNSTLVKKGTVINPGVAALLATFGYSSV
ECCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCEEEECCCEECCHHHHHHHHHCCCHH
HVVKQPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVRYYGQFVDDFET
EEECCCCEEEEECCHHHHHHHHHCCCCCEECCCCEEEEEEEHHCCCCHHHHHHHHHHHHH
CYNNVKKAIKEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVEG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGCELYVRPVIGTYLHRKDSHVFRAEAILQKDFPKANPFTRFVRGR
EEEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHCCE
VEIVDGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGFKAGITVSVLLLELTSGSEWP
EEEEECEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCCC
WKESLRSYK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]