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The map label for this gene is ykpB [H]

Identifier: 222095537

GI number: 222095537

Start: 1855530

End: 1856474

Strand: Direct

Name: ykpB [H]

Synonym: BCQ_1877

Alternate gene names: 222095537

Gene position: 1855530-1856474 (Clockwise)

Preceding gene: 222095535

Following gene: 222095539

Centisome position: 35.59

GC content: 36.4

Gene sequence:

>945_bases
ATGCGTATTTTAGTATTAGGAGCGGGAGGCGTTGGAGGCTTTTTTGGGGGACGCTTAGTAGAAAAAGGAGAAGATGTTAC
TTTTCTTGTTCGTAGTAAACGGAAAAAACAATTGGAGGAAAGAGGACTTGTAATCCGCAGTGTTAATGGGGATTTTTCCT
TCCAACCGAAATTAATAACGAAAGAAGATCAAACTGCTCCATTTGATGTGATTCTATTTTCAACAAAAGCGTATCACTTA
AATGAGGCAATTCAAGATTTGAAGCCGTTTGTAGGTGAAAGTACTGTAATCATTCCGTTGCTAAATGGTATTGCTCATGT
ATCGCTATTACAAAAGGAATTCGGTGAGGAAAAAGTAATTGGTGGTTTATGCTTTATCGAGACGACGTTAAACGATCAAG
GAGAAATTGTACAAACTAGCGCTGCAAATAGACTTATGTTTGGAGAAATGAAGTCTCAAAATTCAGAGAGAATAAAGCAT
ATTTCTAAAGCATTTGCAGGTACGAAATCTAGTTTTATTTTAAGTGAAAACATTATGCAAGATATGTGGCATAAATATTT
ATTTATTACTGTAATGTCCGGTGTGACAACGTTAATGCGTGCACCAATTGGACCAATCCGTGAAAGTGAAGGCGGCCGTG
ATTTTATCCGTAATGTGTTTGAGGAATCTGTACAAATCATGAGAGTATTAGGAGCCCCCGTAAAGGAAAATATTGCCGAG
GAACATATGAAAACGATTGATAAAATTTCGTATGATATGAAGTCATCAATGCAACGTGATATGGAAAAGGGTTCGTTTAT
TGAAGGGAAGCACTTGCAAGGATATTTACTGGATGTAGCAGAGCAATTTTCAATAGCGGCACCATTATTAGGCACTATAT
ATCAAAATTTAAAGGTGTATGAAGAGATGACCTTTAACAGATCTGTAATAGAATTAGATGTATGA

Upstream 100 bases:

>100_bases
CTTGAGTAAGAATGAAAATTCAGCTTATTTAGTAGGGGACATGTATAATGTTATGTATACTGAATGTTATAAAATTGTAT
TTTGAAAAGGGGGATGTTGT

Downstream 100 bases:

>100_bases
AAAAATAAAAAAGAAAGCAATATATAAGTGTATTGCTTTCTTTTTTTATGACAAATCATTTATTTCTTTTTGTTCTATCT
GTCAAATTTATTTCCTGTTC

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLITKEDQTAPFDVILFSTKAYHL
NEAIQDLKPFVGESTVIIPLLNGIAHVSLLQKEFGEEKVIGGLCFIETTLNDQGEIVQTSAANRLMFGEMKSQNSERIKH
ISKAFAGTKSSFILSENIMQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGRDFIRNVFEESVQIMRVLGAPVKENIAE
EHMKTIDKISYDMKSSMQRDMEKGSFIEGKHLQGYLLDVAEQFSIAAPLLGTIYQNLKVYEEMTFNRSVIELDV

Sequences:

>Translated_314_residues
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLITKEDQTAPFDVILFSTKAYHL
NEAIQDLKPFVGESTVIIPLLNGIAHVSLLQKEFGEEKVIGGLCFIETTLNDQGEIVQTSAANRLMFGEMKSQNSERIKH
ISKAFAGTKSSFILSENIMQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGRDFIRNVFEESVQIMRVLGAPVKENIAE
EHMKTIDKISYDMKSSMQRDMEKGSFIEGKHLQGYLLDVAEQFSIAAPLLGTIYQNLKVYEEMTFNRSVIELDV
>Mature_314_residues
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLITKEDQTAPFDVILFSTKAYHL
NEAIQDLKPFVGESTVIIPLLNGIAHVSLLQKEFGEEKVIGGLCFIETTLNDQGEIVQTSAANRLMFGEMKSQNSERIKH
ISKAFAGTKSSFILSENIMQDMWHKYLFITVMSGVTTLMRAPIGPIRESEGGRDFIRNVFEESVQIMRVLGAPVKENIAE
EHMKTIDKISYDMKSSMQRDMEKGSFIEGKHLQGYLLDVAEQFSIAAPLLGTIYQNLKVYEEMTFNRSVIELDV

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 35254; Mature: 35254

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLIT
CEEEEEECCCCCHHHCCHHHHCCCCEEEEHHHHHHHHHHHCCCEEEEECCCCEECCCEEC
KEDQTAPFDVILFSTKAYHLNEAIQDLKPFVGESTVIIPLLNGIAHVSLLQKEFGEEKVI
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHC
GGLCFIETTLNDQGEIVQTSAANRLMFGEMKSQNSERIKHISKAFAGTKSSFILSENIMQ
CEEEEEEECCCCCCCEEECCCCCCEEEHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
DMWHKYLFITVMSGVTTLMRAPIGPIRESEGGRDFIRNVFEESVQIMRVLGAPVKENIAE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EHMKTIDKISYDMKSSMQRDMEKGSFIEGKHLQGYLLDVAEQFSIAAPLLGTIYQNLKVY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEMTFNRSVIELDV
HHHHCCCCEEEEEC
>Mature Secondary Structure
MRILVLGAGGVGGFFGGRLVEKGEDVTFLVRSKRKKQLEERGLVIRSVNGDFSFQPKLIT
CEEEEEECCCCCHHHCCHHHHCCCCEEEEHHHHHHHHHHHCCCEEEEECCCCEECCCEEC
KEDQTAPFDVILFSTKAYHLNEAIQDLKPFVGESTVIIPLLNGIAHVSLLQKEFGEEKVI
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHC
GGLCFIETTLNDQGEIVQTSAANRLMFGEMKSQNSERIKHISKAFAGTKSSFILSENIMQ
CEEEEEEECCCCCCCEEECCCCCCEEEHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
DMWHKYLFITVMSGVTTLMRAPIGPIRESEGGRDFIRNVFEESVQIMRVLGAPVKENIAE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
EHMKTIDKISYDMKSSMQRDMEKGSFIEGKHLQGYLLDVAEQFSIAAPLLGTIYQNLKVY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEMTFNRSVIELDV
HHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]