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The map label for this gene is mdtG [H]

Identifier: 222095519

GI number: 222095519

Start: 1835611

End: 1836825

Strand: Direct

Name: mdtG [H]

Synonym: BCQ_1859

Alternate gene names: 222095519

Gene position: 1835611-1836825 (Clockwise)

Preceding gene: 222095518

Following gene: 222095521

Centisome position: 35.2

GC content: 37.7

Gene sequence:

>1215_bases
ATGGCCAGCTGGAAACGAAATTTAATGATTTGTTGGCTAGGTTGTTTTACCACTGCAGCCGGTATGAGTTTAGTAATTCC
TTTTTTATCTTTTTATATTGAGGAATTAGGGGTGACTGGCACTTCTAGTATTGCACAGTGGTCGGGACTTGCATTTGGTG
TAACATTTTTAATGGGTGCGATCGTATCACCAATATGGGGAAAGCTTGGTGATATACATGGACGGAAATTGATGCTAATT
CGTGCTAGCCTTGGTATGGCGATTATTATGACGCTTATGGGGTTTGTAACGGATGTATATCAACTAGTCGCACTAAGATT
TTTGATGGGAGCAGTATCTGGTTTCCTTTCAACAGCAATGACATTTATTGCAGCAGAAACTCCGCAAGAGCATTCAGGTT
GGGCGATCTCCACAATTTCAACTGGTGGCGTGAGCGGTTCTTTACTTGGACCGTTACTTGGAGGTTATTTATCTGAGTTA
ATTGGAATGCGTCATGTTTTTCTTGTTACAGGAGCTTTTTTATTCCTTTCCTTTCTCATCGTTTTTTTCTTTCTACATGA
AGAAAATCACTCTGCTCAAGCAAAAAAAGTACAAACGAAAAAAGTATGGACGATGGTTCCAGCTAAACATTTGATTATTA
GTTTGTTTGTAACAACATTTATTATTCAACTTGCTAATATGTCTGTTCAGCCAATTGTTACATTGTACGTGAAAAATTTA
GTTGGTCCTCAAACAGCGCATATTGAAACAATTGCAGGCGCCGTTATGTCAGCGACAGGATTAGCTGTTATTTTGGCAGC
ACCAAGATTAGGACGATTATCAGATCATATCGGTCCTCAAAAAACGTTAGTTGTAGCGTTGTTTGCTGCAGGAATTATTT
TTATCCCGCAAGCATTTGTAACCTCAGCTTGGCAACTATTAATTCTTAGATTTTTATTAGGTATTGCACAAGCAGGATTA
TTACCTTCCGTACAAACTCTACTAAAACAACATACACCAACTCATGTAACGGGACGAATATTTGGATATAATCAATCGTT
TCAGTTTTTAGGAAATATGATTGGACCAGTACTTGGTGGACAAATTGCAGCACATGCAGGGTTTCAATATGTTTTCTTCT
CTACATCATCACTATTGTTTATTGCGTGTATTTGGGTTTATTTTCATAATAAGAACGAAGAGGTATCAGAGAAACGACAT
TTGGAAGTTAGTTAA

Upstream 100 bases:

>100_bases
AAATAGCGGGTTTTGTAGTAAATCTTACAAATAAAGCAAATTACTAAACTTTTTATAAGAAAGGGTGTAGAATGGGTATC
TAAAGAAAGAAGGTGTGAAA

Downstream 100 bases:

>100_bases
CTAAGTGAAAGAAAAAAGGATGAAGCAATGATTGCTTCATCCTTTTTTCTTTAAAATTGGAGACAAAGATAACTTAATGT
ACCAAGCTCGTAACTACGGT

Product: multidrug resistance protein b

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLI
RASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPQEHSGWAISTISTGGVSGSLLGPLLGGYLSEL
IGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGL
LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRH
LEVS

Sequences:

>Translated_404_residues
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLI
RASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPQEHSGWAISTISTGGVSGSLLGPLLGGYLSEL
IGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGL
LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRH
LEVS
>Mature_403_residues
ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIR
ASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPQEHSGWAISTISTGGVSGSLLGPLLGGYLSELI
GMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNLV
GPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLL
PSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRHL
EVS

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=243, Percent_Identity=26.3374485596708, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787291, Length=396, Percent_Identity=45.7070707070707, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI87082404, Length=374, Percent_Identity=24.8663101604278, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319871, Length=152, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43876; Mature: 43744

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAM
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFIAAETPQEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLI
HHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV
CCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCC
QIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRHLEVS
HHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA