Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 222095440

GI number: 222095440

Start: 1746800

End: 1748188

Strand: Direct

Name: fumC [H]

Synonym: BCQ_1780

Alternate gene names: 222095440

Gene position: 1746800-1748188 (Clockwise)

Preceding gene: 222095439

Following gene: 222095443

Centisome position: 33.5

GC content: 37.37

Gene sequence:

>1389_bases
ATGGAGTACAGAATTGAAAGAGATACATTAGGAGAAATTAAAGTTCCAGCTGATAAATTATGGGCAGCACAAACACAACG
TAGTAAAGAAAACTTCCCGATTGGAACAGAGCAAATGCCGCTTGAAATTGTAAAAGCATTTGCCATTTTAAAGAAGAGTG
CAGCACTTACTAATAAAAAATTAGGAAAGCTATCAGAAGAAAAAGCAGAAGCAATTGTGACAGCAGCTGACGAAGTGATA
GTAGGGAAATGGAATGAACATTTTCCACTTGTCGTATGGCAAACAGGTAGTGGTACTCAGTCAAACATGAATGTGAATGA
AGTAATTGCAAACCGAGGGAATCAAATTTTGAAAGAGAAAGGATTTGACGTACATATTCATCCGAATGATGATGTGAACA
TGTCTCAAAGTTCAAATGATACTTTCCCAACTGCGCTTCATGTAGCATGTGTACTCGCAGTAGAAAATCACGTGTTACCA
GCAATTACGAAATTAAAAGAAACGTTAGCAGAAAAAGTAAAAGCATTTGAACATATTATAAAAATTGGTCGTACACATTT
ACAAGATGCGACACCGTTAACATTAGGACAAGAAATTAGTGGATGGCACCGTATGCTTGAAAAAACAGAGCGTATGATTG
CAGAGAGCAATACATATATGAAAGAGCTTGCGATTGGTGGTACTGCAGTTGGAACAGGTATAAACGCCCATCCTAAATTT
GGTGAGATGGTATCTGAGGAAATTAGCCAATTTACAGGTAAGCAATTTATTTCTGCACCAAATAAATTCCATGCATTAAC
GAGTCATGATGAAGTTGTATATACGCATGGAGCATTAAAAGCATTAGCAGCGGATTTAATGAAAATCGCTAACGATGTGC
GCTGGCTGGCAAGTGGTCCACGTAGTGGGCTAGGAGAAATTATTATTCCAGCAAATGAGCCAGGAAGCTCTATTATGCCA
GGTAAAGTAAATCCAACGCAAAGTGAAGCGTTAACGATGGTTGTAGCACAAGTGATGGGAAATGACGCAACAATCGGATT
TGCAGCGAGCCAAGGCAATTTTGAGTTAAATGTATTTAAACCTGTTATTGCATATAACTTCTTACAATCTGCTCACTTAT
TAGCAGATGCAATTGTTTCATTTAATGATAATTGTGCAGTTGGTATTGAAGCAGATGAAGAAGTCATTAAAGAGAATGTG
AATCGTTCATTAATGCTTGTTACAGCATTAAATCCGCATATCGGATATGAAAATGCAGCGAAAATTGCGAAGCATGCTCA
TAAAGAAGGGTTAACTTTAAAAGAAGCAGCATTGCAATCTGGATTACTAACAGAAGCACAATTTGATGAAATTGTCGATC
CGAAAAAAATGATTGCTCCGAAAGAGTAA

Upstream 100 bases:

>100_bases
ATATAAAATATCTATTTATATGAGTGAGAATTCTTATCATTTAAAGGGAAGTCTGTTATTATAAGAAATGTAGGTATTAT
ATTTTCAAGGGGATGAAAAC

Downstream 100 bases:

>100_bases
TAAAAACGCCAAGATTCTTTGTTTAGAATCTTGGTTTTTTTATTACTGTAAATGCCAAAATATATTATTTGTTAGCAGAC
ATATTCAATATTTTCATATG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALTNKKLGKLSEEKAEAIVTAADEVI
VGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGFDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVKAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEAQFDEIVDPKKMIAPKE

Sequences:

>Translated_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALTNKKLGKLSEEKAEAIVTAADEVI
VGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGFDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVKAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEAQFDEIVDPKKMIAPKE
>Mature_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALTNKKLGKLSEEKAEAIVTAADEVI
VGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGFDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVKAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEAQFDEIVDPKKMIAPKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=59.0909090909091, Blast_Score=530, Evalue=1e-150,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=61.7067833698031, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.4793926247288, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=57.9175704989154, Blast_Score=532, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=56.7073170731707, Blast_Score=379, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.351409978308, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.8965517241379, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.8965517241379, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=54.9568965517241, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.763440860215, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.4516129032258, Blast_Score=422, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50391; Mature: 50391

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALTNKK
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVTAADEVIVGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HHCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GFDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVKAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEAQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALTNKK
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVTAADEVIVGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HHCHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GFDVHIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVKAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEAQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]