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The map label for this gene is pbuX [H]

Identifier: 222095296

GI number: 222095296

Start: 1601178

End: 1602500

Strand: Direct

Name: pbuX [H]

Synonym: BCQ_1636

Alternate gene names: 222095296

Gene position: 1601178-1602500 (Clockwise)

Preceding gene: 222095295

Following gene: 222095298

Centisome position: 30.71

GC content: 38.78

Gene sequence:

>1323_bases
ATGAAGCAACATCCATTTAAAATCGCATCGCTTGGTATGCAGCATATGCTTGCTATGTATGCTGGCGCAATTATCGTTCC
GCTTATTGTGGGCGGCGGACTTGGTTTAAATCAAAAAGAGTTAACATATTTAGTCTCAATTGATTTATTAATGTGCGGCG
TTGCGACAATTTTACAAGCATTATCAAATCGCTTTTTCGGTATTGGACTCCCAGTTGTACTAGGTTGTACATTTACAGCC
GTTGGGCCGATGATTGCAATCGGAAAACAATACGGCGTATCCTCTATTTATGGAGCAATTATTGCTGCGGGGTTATTCGT
TGTTATTTTTGCGAAATTATTTGGAAAGCTTGTAAAGCTGTTTCCACCTGTTGTAACAGGATCTGTCGTTACCGTAATTG
GAGTTACACTTGTTCCAGCAGCAATTAATGATATGGCTGGAGGAGTAGGAAGTAAGGATTTCGGTAGTCTTGAAAATTTA
GCATTAGCATTTGGTGTGTTACTATTTATTATCATTATGTATCGTTTCTTTGACGGATTTATTCGTTCAATCTCTATTTT
ACTAGGTCTATTGTTCGGTACAATCGTTGCAGCATTTATGGGGAAAGTAAGCTTGCAAGCGGTTGGAGAAGCGGATTGGT
TCCATGGTATTCAGCCATTTTATTTCGGTACACCAACGTTTGAATTAACGCCAATTATTACGATGATTCTCGTTGCTTGC
GTAGGGATTGTAGAAGCGACAGGTGTTTACTTTGCATTATCTGATATTTGCAATAAAAAGATTGGTGAAAAAGAATTAAC
AAAAGGGTATCGTGCAGAAGGATTAGCGATGGTGTTAGGTGGTATTTTCAACGCCTTTCCGTATACAACATACTCACAAA
ACGTAGGGCTTGTTCAATTAACTGGAGTAAGAAATCGCGTGATTATTTACACGTGTGGTGGTATGTTAATCGTTCTTGGA
TTCATTCCAAAAATCGCAGCTATTACAACAATCATTCCGAAATCAGTACTTGGCGGTGCGATGTTAGCGATGTTCGGTAT
GGTAATGGCATATGGTATTAAAATGTTAAGTAGCGTTGATTTTGGAAGACAAGAAAATTTATTAATCGTTGCATGTTCTG
TTGGGATCGGACTAGGAGTTACTGTCGTTCCTACATTATTCTCACAACTTCCAGAAAGCATTCGTATTTTAACAGATAAC
GGAATCGTACTAGGAAGTGCGTCAGCAGTCCTTTTAAATATCGTATTTAATATGGTGCCGCAGCGTAAAGTGAAAGTAAA
GGATGAACCAGTTCCGATACAAAGTGCGGTAAGAGAAGCATAA

Upstream 100 bases:

>100_bases
TGAACAAGGAATTCGTGTTGAGTCACTAGCAGAAATTGCATCACTTGATAATAACGCAGTTACATTTGTACAGCAAGAAA
CTGCGGAGGTGAAATAAACG

Downstream 100 bases:

>100_bases
AAAAGCAAGGTCTCACTATGAGACCTTGCTTTTCTTTTTAAGTGGCATCATCTTTCCGTACGTACCAAGGCGCCATATAT
ACTCAAGTGGTCCGTATTGG

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKQHPFKIASLGMQHMLAMYAGAIIVPLIVGGGLGLNQKELTYLVSIDLLMCGVATILQALSNRFFGIGLPVVLGCTFTA
VGPMIAIGKQYGVSSIYGAIIAAGLFVVIFAKLFGKLVKLFPPVVTGSVVTVIGVTLVPAAINDMAGGVGSKDFGSLENL
ALAFGVLLFIIIMYRFFDGFIRSISILLGLLFGTIVAAFMGKVSLQAVGEADWFHGIQPFYFGTPTFELTPIITMILVAC
VGIVEATGVYFALSDICNKKIGEKELTKGYRAEGLAMVLGGIFNAFPYTTYSQNVGLVQLTGVRNRVIIYTCGGMLIVLG
FIPKIAAITTIIPKSVLGGAMLAMFGMVMAYGIKMLSSVDFGRQENLLIVACSVGIGLGVTVVPTLFSQLPESIRILTDN
GIVLGSASAVLLNIVFNMVPQRKVKVKDEPVPIQSAVREA

Sequences:

>Translated_440_residues
MKQHPFKIASLGMQHMLAMYAGAIIVPLIVGGGLGLNQKELTYLVSIDLLMCGVATILQALSNRFFGIGLPVVLGCTFTA
VGPMIAIGKQYGVSSIYGAIIAAGLFVVIFAKLFGKLVKLFPPVVTGSVVTVIGVTLVPAAINDMAGGVGSKDFGSLENL
ALAFGVLLFIIIMYRFFDGFIRSISILLGLLFGTIVAAFMGKVSLQAVGEADWFHGIQPFYFGTPTFELTPIITMILVAC
VGIVEATGVYFALSDICNKKIGEKELTKGYRAEGLAMVLGGIFNAFPYTTYSQNVGLVQLTGVRNRVIIYTCGGMLIVLG
FIPKIAAITTIIPKSVLGGAMLAMFGMVMAYGIKMLSSVDFGRQENLLIVACSVGIGLGVTVVPTLFSQLPESIRILTDN
GIVLGSASAVLLNIVFNMVPQRKVKVKDEPVPIQSAVREA
>Mature_440_residues
MKQHPFKIASLGMQHMLAMYAGAIIVPLIVGGGLGLNQKELTYLVSIDLLMCGVATILQALSNRFFGIGLPVVLGCTFTA
VGPMIAIGKQYGVSSIYGAIIAAGLFVVIFAKLFGKLVKLFPPVVTGSVVTVIGVTLVPAAINDMAGGVGSKDFGSLENL
ALAFGVLLFIIIMYRFFDGFIRSISILLGLLFGTIVAAFMGKVSLQAVGEADWFHGIQPFYFGTPTFELTPIITMILVAC
VGIVEATGVYFALSDICNKKIGEKELTKGYRAEGLAMVLGGIFNAFPYTTYSQNVGLVQLTGVRNRVIIYTCGGMLIVLG
FIPKIAAITTIIPKSVLGGAMLAMFGMVMAYGIKMLSSVDFGRQENLLIVACSVGIGLGVTVVPTLFSQLPESIRILTDN
GIVLGSASAVLLNIVFNMVPQRKVKVKDEPVPIQSAVREA

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=224, Percent_Identity=28.125, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI40316845, Length=224, Percent_Identity=28.125, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI44680145, Length=428, Percent_Identity=23.5981308411215, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI44680143, Length=449, Percent_Identity=23.3853006681514, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87082181, Length=429, Percent_Identity=41.958041958042, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790087, Length=428, Percent_Identity=30.1401869158879, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082178, Length=434, Percent_Identity=32.4884792626728, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081818, Length=456, Percent_Identity=28.0701754385965, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788843, Length=377, Percent_Identity=28.3819628647215, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87081750, Length=444, Percent_Identity=21.3963963963964, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=441, Percent_Identity=24.2630385487528, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=192, Percent_Identity=28.6458333333333, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17541904, Length=423, Percent_Identity=24.113475177305, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993493, Length=436, Percent_Identity=22.4770642201835, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17542260, Length=190, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356175, Length=418, Percent_Identity=25.8373205741627, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46600; Mature: 46600

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCEECCCCCCCHHHHHCCC
>Mature Secondary Structure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CCCEECCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]