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The map label for this gene is panB [H]

Identifier: 222095268

GI number: 222095268

Start: 1575974

End: 1576783

Strand: Direct

Name: panB [H]

Synonym: BCQ_1608

Alternate gene names: 222095268

Gene position: 1575974-1576783 (Clockwise)

Preceding gene: 222095267

Following gene: 222095269

Centisome position: 30.22

GC content: 41.23

Gene sequence:

>810_bases
ATGAAAGAGCAAGGTGAGCCGATTACAATGCTAACGGCGTATGATTATCCATCTGCTAAGTTAGCAGAAGAAGCGGAAGT
TGATATGATTTTAGTTGGAGATTCCCTTGGGATGGTTGTGCTCGGCTATGATTCAACAGTACCTGTAACAGTAGAGGATA
TGATTCATCATACGAAAGCTGTACGCCGAGGAGCGAAAGAGACGTTTATTGTAACTGATATGCCATTTATGTCGTATCAT
GTGTCGCCTCAAGATACGATGGTGAATGCACGCCGCATCGTTCAAGAGAGTGGTGCTCATGCACTGAAGGTAGAAGGTGC
AGGAGAAGTGATATCAACTATTCATTACTTGACGAGTGCGGGAATTCCTGTCGTGGCACACTTAGGCTTAACTCCTCAAT
CTGTAGGAGTGTTAGGTGGCTATAAAGTACAAGGAAAAGATGCTGAAAGTGCAAAAAAATTAATAGAAGATGCGAAGAGA
TGTGAGGAAGCTGGTGCGATAGCACTTGTATTAGAATGTGTGCCAATGCAGCTAGCAAAATTTATTTCGAAGCAACTAAC
AATTCCAACGATTGGAATTGGAGCAGGACAAAAAGTGGATGGGCAAGTACTCGTTTATCATGATCTTATCTCATATGGCG
TAAATCGTGTTCCGAAATTTGTTAAGCAATATACGTCTGTTCAAGAGGAGATTGTGCGAGGGATTTCACAATACGTAACT
GAAGTAAAGACAGGTCAATTTCCGGAAGAAAAACATTCATTCACAATGAAAGAGGAAGAATGTTTAGCGTTATACGGAGG
AAAACAATAA

Upstream 100 bases:

>100_bases
CCTTTTATGGCCAGAGGGGTTTTTTATATGATTTCGGCCATCTCCTCTCTCCTGTATAAAGGAGGAGTAGTTTTTGAAAA
CAAAAACAGATTTTTTGAAA

Downstream 100 bases:

>100_bases
TGAAAATCATAAATACAGTGCAAGAGATGCAGCAAATTACAAACGAACTACGTGCAAGTGGAAAAAGTATCGGTTTTGTC
CCAACGATGGGTTATTTACA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKEQGEPITMLTAYDYPSAKLAEEAEVDMILVGDSLGMVVLGYDSTVPVTVEDMIHHTKAVRRGAKETFIVTDMPFMSYH
VSPQDTMVNARRIVQESGAHALKVEGAGEVISTIHYLTSAGIPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLIEDAKR
CEEAGAIALVLECVPMQLAKFISKQLTIPTIGIGAGQKVDGQVLVYHDLISYGVNRVPKFVKQYTSVQEEIVRGISQYVT
EVKTGQFPEEKHSFTMKEEECLALYGGKQ

Sequences:

>Translated_269_residues
MKEQGEPITMLTAYDYPSAKLAEEAEVDMILVGDSLGMVVLGYDSTVPVTVEDMIHHTKAVRRGAKETFIVTDMPFMSYH
VSPQDTMVNARRIVQESGAHALKVEGAGEVISTIHYLTSAGIPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLIEDAKR
CEEAGAIALVLECVPMQLAKFISKQLTIPTIGIGAGQKVDGQVLVYHDLISYGVNRVPKFVKQYTSVQEEIVRGISQYVT
EVKTGQFPEEKHSFTMKEEECLALYGGKQ
>Mature_269_residues
MKEQGEPITMLTAYDYPSAKLAEEAEVDMILVGDSLGMVVLGYDSTVPVTVEDMIHHTKAVRRGAKETFIVTDMPFMSYH
VSPQDTMVNARRIVQESGAHALKVEGAGEVISTIHYLTSAGIPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLIEDAKR
CEEAGAIALVLECVPMQLAKFISKQLTIPTIGIGAGQKVDGQVLVYHDLISYGVNRVPKFVKQYTSVQEEIVRGISQYVT
EVKTGQFPEEKHSFTMKEEECLALYGGKQ

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=253, Percent_Identity=47.0355731225296, Blast_Score=242, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319653, Length=263, Percent_Identity=40.6844106463878, Blast_Score=202, Evalue=4e-53,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29303; Mature: 29303

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEQGEPITMLTAYDYPSAKLAEEAEVDMILVGDSLGMVVLGYDSTVPVTVEDMIHHTKA
CCCCCCCEEEEEECCCCCHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEHHHHHHHHHH
VRRGAKETFIVTDMPFMSYHVSPQDTMVNARRIVQESGAHALKVEGAGEVISTIHYLTSA
HHCCCCCEEEEECCCHHEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHC
GIPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLIEDAKRCEEAGAIALVLECVPMQLAK
CCCEEEECCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FISKQLTIPTIGIGAGQKVDGQVLVYHDLISYGVNRVPKFVKQYTSVQEEIVRGISQYVT
HHHHCCCCCEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVKTGQFPEEKHSFTMKEEECLALYGGKQ
HHHCCCCCCHHHCCCCCHHHHHEECCCCC
>Mature Secondary Structure
MKEQGEPITMLTAYDYPSAKLAEEAEVDMILVGDSLGMVVLGYDSTVPVTVEDMIHHTKA
CCCCCCCEEEEEECCCCCHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEHHHHHHHHHH
VRRGAKETFIVTDMPFMSYHVSPQDTMVNARRIVQESGAHALKVEGAGEVISTIHYLTSA
HHCCCCCEEEEECCCHHEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHC
GIPVVAHLGLTPQSVGVLGGYKVQGKDAESAKKLIEDAKRCEEAGAIALVLECVPMQLAK
CCCEEEECCCCHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FISKQLTIPTIGIGAGQKVDGQVLVYHDLISYGVNRVPKFVKQYTSVQEEIVRGISQYVT
HHHHCCCCCEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVKTGQFPEEKHSFTMKEEECLALYGGKQ
HHHCCCCCCHHHCCCCCHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA