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The map label for this gene is gltT [H]

Identifier: 222095165

GI number: 222095165

Start: 1478149

End: 1479420

Strand: Direct

Name: gltT [H]

Synonym: BCQ_1505

Alternate gene names: 222095165

Gene position: 1478149-1479420 (Clockwise)

Preceding gene: 222095162

Following gene: 222095166

Centisome position: 28.35

GC content: 36.01

Gene sequence:

>1272_bases
ATGAAAAGAATAGGACTTGCATGGCAAATATTAATAGGACTTGTGCTTGGTATTGCGGTTGGTGCGATTTTCTTTGGCAA
TCCAGCAGTGGTGAGTTACTTACAACCAATTGGTGATATTTTCATCCGACTAATTAAAATGATTGTAGTACCGATTGTTG
TAGCAAGTATTGTTGTTGGGGTTGCTGGTGTTGGCGATGTTAAAAAATTAGGTCGACTAGGCGGAAAAACAATTATTTAC
TTTGAAATTATTACAACAATTGCAATTATTGTCGGTCTATTAATTGCGAATATTTTCCAACCAGGAAAAGGCGTAAATAT
GGAGCAGTTAACAAAGACAGATATTTCGAAATATACACATACGACAGAGCAAGTACAAAGTCATTCGTTTGCAGATACAT
TTGTAAATATTGTTCCAACAAACATTGTAAAGTCATTAGCTGACGGAGATATGCTTGCTATTATCTTCTTCTCTGTATTA
TTTGGTTTAGGTGTAGCAGCAATTGGTGAAAGAGGAAGACCGGTTCTTCAATTTTTCCAAGGTGTAGCTGATGCGATGTT
TTACGTAACAAATCAAGTTATGAAATTTGCACCATTTGGTGTGTTTGCACTAATTGGAGTTACAGTTTCTACATTTGGTC
TTGCTTCGTTAATTCCATTAGGGAAATTATTAATTGTAGTATACGGGGCAATGATTTTCTTCGTTGTAGTTGTCTTAGGA
CTTACAGCGAAAATATTTGGAATTAACATTTTCCAATTCTTTAAGATTTTAAAAGACGAGCTGATCTTAGCATATTCTAC
AGCGAGTTCAGAAACAGTTTTACCGAAAATCATGGAGAAGATGGAGAAGTTCGGTTGTCCGAAAGCAATTACATCTTTCG
TTATTCCGACAGGTTATTCATTTAACTTAGATGGATCAACTTTATATCAAGCAATTGCGGCTATTTTCTTAGCGCAAATG
TACGGTATTGATTTATCCATTACACAACAAATTACATTATTGCTTGTATTAATGGTTACATCAAAAGGTATCGCAGGTGT
ACCAGGCGTATCGTTCGTTGTATTATTAGCGACACTTGGTACAGTAGGTATTCCACCTGAAGGTTTAGCGTTTATTGCAG
GTATTGACCGTATTCTAGATATGGCTCGTACAGCAGTTAACGTTGTAGGTAACTCTTTAGCAGCTGTAGTTATGTCTAAA
TGGGAAGGTCAATATGACGCTGAAAAAGGACAAGCCTACTTGAAAGAAATTTCTAATAAGCAAGCAGCGTAA

Upstream 100 bases:

>100_bases
GTAGTGAATTGTCGAATAATATGTAATACTCTTAATTTCAAGTTTTATAGATATAGAATGAGAGGTAGAGTGACACATCG
AAGAGGGGGTTACAACAAAT

Downstream 100 bases:

>100_bases
TTATAATTTGAACAAGCTCTCACATAATATGTGGGGGCTTTTCTATATAGAAGGGGAGCAGACGTAATGAAACGTAAATA
TGGTGACGGTTCTTCGTGGG

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKRIGLAWQILIGLVLGIAVGAIFFGNPAVVSYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIVKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA

Sequences:

>Translated_423_residues
MKRIGLAWQILIGLVLGIAVGAIFFGNPAVVSYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIVKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA
>Mature_423_residues
MKRIGLAWQILIGLVLGIAVGAIFFGNPAVVSYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTIAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIVKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITQQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPPEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=425, Percent_Identity=27.7647058823529, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI40254478, Length=480, Percent_Identity=27.7083333333333, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4827012, Length=457, Percent_Identity=27.5711159737418, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI169790839, Length=457, Percent_Identity=27.3522975929978, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI194239697, Length=474, Percent_Identity=28.2700421940928, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI66773030, Length=460, Percent_Identity=27.1739130434783, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI5032093, Length=433, Percent_Identity=25.8660508083141, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=26.8115942028986, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=26.8115942028986, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=26.2032085561497, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI301601644, Length=185, Percent_Identity=31.3513513513514, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=63.0232558139535, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1789947, Length=418, Percent_Identity=39.2344497607655, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=27.3607748184019, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789473, Length=256, Percent_Identity=23.828125, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=426, Percent_Identity=29.1079812206573, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71996953, Length=470, Percent_Identity=27.8723404255319, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71983106, Length=453, Percent_Identity=26.4900662251656, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71983099, Length=453, Percent_Identity=26.4900662251656, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=447, Percent_Identity=27.5167785234899, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=25.3731343283582, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=430, Percent_Identity=23.953488372093, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583025, Length=409, Percent_Identity=24.6943765281174, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17137668, Length=409, Percent_Identity=24.6943765281174, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24583023, Length=409, Percent_Identity=24.6943765281174, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281360483, Length=443, Percent_Identity=24.8306997742664, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17137666, Length=443, Percent_Identity=24.8306997742664, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI281360481, Length=443, Percent_Identity=24.8306997742664, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45224; Mature: 45224

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]