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The map label for this gene is hisH [H]

Identifier: 222095141

GI number: 222095141

Start: 1456818

End: 1457447

Strand: Direct

Name: hisH [H]

Synonym: BCQ_1481

Alternate gene names: 222095141

Gene position: 1456818-1457447 (Clockwise)

Preceding gene: 222095140

Following gene: 222095142

Centisome position: 27.94

GC content: 36.51

Gene sequence:

>630_bases
TTGATTGCCATTATAGATTATGGAATGGGAAACATTCGTAGTGTAGAACAAGCATTAAAGCATATTGGAGCAGCGTACAT
TGTAACGAGTGATAAAGAAGAGATTTTTAGAAGTGATGGAGTGATTTTACCAGGAGTAGGTGCATTTCCAAAAGCGATGG
ATGTATTGGAAGAAAAAGATTTAGTACGTGTGTTACAAGAAATTGGGCGTTCCAGAAAACCACTTCTAGGTATTTGCCTA
GGAATGCAGCTTTTATTTGAAAAAAGTGAGGAACTACAAGACTGTAACGGGTTAAGTTTATTGCCAGGCGTTATTCGAAA
GTTAAAGGTTCCTTATAAAATTCCTCATATGGGATGGAATGAGTTAAAGAAAGAAGGAGAAATAGCGCTTTGGAATGGAG
TAGAGGACGGTTCTTTCGTATATTATGTCCACTCTTATTACGCAGATTGTCCAAATGAAATTGTATATGGAATAAGTGAA
TATGGAGTGAAAGTACCTGGTTTTGTAGCAAAAGGAAATATATACGGTGCGCAGTTTCATCCTGAAAAAAGTGGTGACAT
TGGCATGCAAATGTTGAAAAATTTTAAAGGAGTGGTAGAAACATGGAAATCTTCCCAGCTATCGATTTAA

Upstream 100 bases:

>100_bases
AATTGAAGCGTTATTTAAAGCGTTTGGTAGAGCGCTTAGAGAAGCAGTCGAAAGAAATGCCAATATTACTGGTGTAAATT
CAACGAAAGGGATGTTGTAA

Downstream 100 bases:

>100_bases
AAGAAGGGAGATGCGTTAGACTGTATCAAGGAGAATTTAGTAAAGAAACAGTAATGAATGAAGACCCAGTTGCGCAAGCG
ATTATATTTGAAACATTTGG

Product: imidazole glycerol phosphate synthase subunit hish

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIAIIDYGMGNIRSVEQALKHIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDVLEEKDLVRVLQEIGRSRKPLLGICL
GMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISE
YGVKVPGFVAKGNIYGAQFHPEKSGDIGMQMLKNFKGVVETWKSSQLSI

Sequences:

>Translated_209_residues
MIAIIDYGMGNIRSVEQALKHIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDVLEEKDLVRVLQEIGRSRKPLLGICL
GMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISE
YGVKVPGFVAKGNIYGAQFHPEKSGDIGMQMLKNFKGVVETWKSSQLSI
>Mature_209_residues
MIAIIDYGMGNIRSVEQALKHIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDVLEEKDLVRVLQEIGRSRKPLLGICL
GMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISE
YGVKVPGFVAKGNIYGAQFHPEKSGDIGMQMLKNFKGVVETWKSSQLSI

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=200, Percent_Identity=40, Blast_Score=134, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319725, Length=208, Percent_Identity=31.25, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 23260; Mature: 23260

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIDYGMGNIRSVEQALKHIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDVLEEKD
CEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHHHHHCCCEEECCCCCCHHHHHHHHHHH
LVRVLQEIGRSRKPLLGICLGMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEECCCCCHH
ELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISEYGVKVPGFVAKGNIYGAQFH
HHHCCCCEEEECCCCCCCEEEEEEHHHHCCHHHHHHHHHHCCCCCCCEEECCCEEECEEC
PEKSGDIGMQMLKNFKGVVETWKSSQLSI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIAIIDYGMGNIRSVEQALKHIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDVLEEKD
CEEEEECCCCCHHHHHHHHHHCCEEEEEECCHHHHHHCCCEEECCCCCCHHHHHHHHHHH
LVRVLQEIGRSRKPLLGICLGMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEECCCCCHH
ELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISEYGVKVPGFVAKGNIYGAQFH
HHHCCCCEEEECCCCCCCEEEEEEHHHHCCHHHHHHHHHHCCCCCCCEEECCCEEECEEC
PEKSGDIGMQMLKNFKGVVETWKSSQLSI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA