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The map label for this gene is hisB [H]

Identifier: 222095140

GI number: 222095140

Start: 1456233

End: 1456817

Strand: Direct

Name: hisB [H]

Synonym: BCQ_1480

Alternate gene names: 222095140

Gene position: 1456233-1456817 (Clockwise)

Preceding gene: 222095139

Following gene: 222095141

Centisome position: 27.93

GC content: 38.97

Gene sequence:

>585_bases
ATGCGTGAGTCTAGTCAAATACGTGAGACGACAGAGACAAAAATAAAATTAAGTTTACAGCTTGATGATGGGAAGAACGT
TTCTGTACGAACGGGAGTTGGTTTTTTTGATCATATGCTAACTTTATTTGCAAGGCATGGAAGATTCGGTTTGCAAGTGG
AGGCAGAAGGGGATGTATTCGTTGATGCACATCATACAGTTGAGGATGTTGGGATTGTACTCGGAAATTGTTTGAAAGAA
GCCTTGCACAGTAAAGAGGGGATTAACAGGTACGGCTCAGCATATGTACCGATGGATGAGTCTTTAGGCTTTGTTGCAAT
TGATATAAGTGGACGCTCATATATTGTATTTCAAGGAGAATTAACGAATCCGAAGCTTGGGGATTTTGATACAGAACTAA
CGGAAGAATTTTTTAGAGCAGTTGCTCATGCTGCCAATATTACATTACATGCTCGTATTTTATACGGAAGCAATACACAT
CACAAAATTGAAGCGTTATTTAAAGCGTTTGGTAGAGCGCTTAGAGAAGCAGTCGAAAGAAATGCCAATATTACTGGTGT
AAATTCAACGAAAGGGATGTTGTAA

Upstream 100 bases:

>100_bases
CATTAAGAGATGTAAAACATCATATTGTAGAGCTTGCCAGTAAAGAAGGGTTACATGCGCATGCGAGAGCAATTCAAATA
AGATTTGAGGAGGAAGAATA

Downstream 100 bases:

>100_bases
TTGATTGCCATTATAGATTATGGAATGGGAAACATTCGTAGTGTAGAACAAGCATTAAAGCATATTGGAGCAGCGTACAT
TGTAACGAGTGATAAAGAAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNANITGVNSTKGML

Sequences:

>Translated_194_residues
MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNANITGVNSTKGML
>Mature_194_residues
MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNANITGVNSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=44.559585492228, Blast_Score=173, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=211, Percent_Identity=38.8625592417062, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21483; Mature: 21483

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCCHHHHHCCCEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGE
EECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVER
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NANITGVNSTKGML
CCCEEECCCCCCCC
>Mature Secondary Structure
MRESSQIRETTETKIKLSLQLDDGKNVSVRTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCCHHHHHCCCEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALHSKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGE
EECCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVER
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NANITGVNSTKGML
CCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA