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The map label for this gene is comC [H]

Identifier: 222095039

GI number: 222095039

Start: 1370208

End: 1370930

Strand: Direct

Name: comC [H]

Synonym: BCQ_1379

Alternate gene names: 222095039

Gene position: 1370208-1370930 (Clockwise)

Preceding gene: 222095038

Following gene: 222095040

Centisome position: 26.28

GC content: 34.3

Gene sequence:

>723_bases
ATGTTCACTTATGTATATGCATTGTTAGCGGGGATGGTGTTTGGTTCTTTTTTTATGGTAATTGCGATGAGAGTTCCGCT
AGGGGAGTCTATCATAACCCCGCGTTCATATTGTCATTATTGTAAGTATGTGCTAAAGCCAAAAGAATTGATTCCAATCA
TTTCTTTTTGTATGCAAAGAGGGCGTTGTACGAATTGTAAGAGGAAAATTTCAATTTTGTACGTAGTATTTGAACTTGTA
ACTGGAATGATATGTCTTCTTACTGTATATATGATTGGGGTGGAACGAGAGCTTATTATCGTTTTATCACTTTTTGCGTT
ACTTCTTATTATTTCAGTTACAGATTACATATATATGTTAATTCCAAATCGTATTTTAGCTTGGTTTGCTTGTTTACTCA
TTTTAGAATGTGCTTTTATACCGTTAGTCACTTGGATAGATAGTATAGTTGGTAGTTGCGTTATATTCATTTTGTTATAC
TGCATGCAAAAGATATATCCAGAAGGGCTTGGGGGAGGGGATATAAAATTACTTTCGTTACTTGGATTTATAGTGGGACT
GAAAGGGATTTTTATCGTTTTATTTTTAGCATCTTGCTTTAGTCTTTGTTTCTTTGGAGCTGGTCTCGTATTAAAACGTA
TGAAAATGAGGACTCAAATACCGTTTGGTCCTTTTATTAGTCTTGGGGCAATATGTTACATGTTGGTCACGTATGCAAAA
TAG

Upstream 100 bases:

>100_bases
CAGGCCAGAAAATGGCCTGCTTTTTTAATAGAATAGAGATAATATGAAGTAGAAGTTCTCTCCTTTTTTTGCTATGTTCT
TTTGGAAAGGAGAGGAAGGG

Downstream 100 bases:

>100_bases
AGAGGGGATAGAAAATGAATGTATATATGGATGATCAAAGAAGTTGTCCGTACGGTTACGTGCTCGCAACTACAGTAGAA
TGTGCTTTGCAAATGGTACG

Product: late competence protein comc

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MFTYVYALLAGMVFGSFFMVIAMRVPLGESIITPRSYCHYCKYVLKPKELIPIISFCMQRGRCTNCKRKISILYVVFELV
TGMICLLTVYMIGVERELIIVLSLFALLLIISVTDYIYMLIPNRILAWFACLLILECAFIPLVTWIDSIVGSCVIFILLY
CMQKIYPEGLGGGDIKLLSLLGFIVGLKGIFIVLFLASCFSLCFFGAGLVLKRMKMRTQIPFGPFISLGAICYMLVTYAK

Sequences:

>Translated_240_residues
MFTYVYALLAGMVFGSFFMVIAMRVPLGESIITPRSYCHYCKYVLKPKELIPIISFCMQRGRCTNCKRKISILYVVFELV
TGMICLLTVYMIGVERELIIVLSLFALLLIISVTDYIYMLIPNRILAWFACLLILECAFIPLVTWIDSIVGSCVIFILLY
CMQKIYPEGLGGGDIKLLSLLGFIVGLKGIFIVLFLASCFSLCFFGAGLVLKRMKMRTQIPFGPFISLGAICYMLVTYAK
>Mature_240_residues
MFTYVYALLAGMVFGSFFMVIAMRVPLGESIITPRSYCHYCKYVLKPKELIPIISFCMQRGRCTNCKRKISILYVVFELV
TGMICLLTVYMIGVERELIIVLSLFALLLIISVTDYIYMLIPNRILAWFACLLILECAFIPLVTWIDSIVGSCVIFILLY
CMQKIYPEGLGGGDIKLLSLLGFIVGLKGIFIVLFLASCFSLCFFGAGLVLKRMKMRTQIPFGPFISLGAICYMLVTYAK

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=256, Percent_Identity=31.25, Blast_Score=91, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27081; Mature: 27081

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
10.4 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
10.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]